Navigation Links
U of MN researchers reverse memory loss in mice

Researchers at the University of Minnesota were able to reverse memory loss in mice with significant brain degeneration for the first time, a breakthrough that offers hope to the estimated 4 million people living with Alzheimer's disease.

Researchers first manipulated the genetic makeup of the mice so they developed dementia; the mice experienced memory loss that worsens over time and had brain atrophy similar to what a person with Alzheimer's disease goes through. The researchers further designed the mice so that the transgene that causes these symptoms could be "turned off." Transgenes are genes from one organism that have been incorporated into another organism.

The researchers predicted that when the transgene expressing the dementia was turned off, memory loss would stop. The results, however, surpassed their expectations. The mice's symptoms of dementia were reversed--in other words, they regained memory.

"Most Alzheimer's disease treatments focus on slowing the symptoms or preventing the disease from progressing, but our research suggests that in the future we may be able to reverse the effects of memory loss, even in patients who have lost brain or neural tissue," said Karen Ashe, professor of neurology and lead author of the study.

The results will be published in the July 15 issue of the journal Science.

In the past, it was generally accepted that dementia was caused by two substances that accumulate in the brain: neurofibrillary tangles, which are tangled bundles of fibers in neurons, and amyloid deposits, a toxic build-up of plaque in the brain. The researchers found that even after the memory loss was regained in the mice, the tangles remained, and even increased in number. This suggests that the tangles are not a cause of dementia as previously thought.

The mice serve as a model that shows how the disease progresses as well as the possibility that memory loss can be reversed. The research suggests that the
'"/>

Source:University of Minnesota


Page: 1 2

Related biology news :

1. NYU researchers simulate molecular biological clock
2. Vital step in cellular migration described by UCSD medical researchers
3. ASU researchers finds novel chemistry at work to provide parrots vibrant red colors
4. UCSD researchers maintain stem cells without contaminated animal feeder layers
5. Why do insects stop breathing? To avoid damage from too much oxygen, say researchers
6. New protein discovered by Hebrew University researchers
7. First real-time view of developing neurons reveals surprises, say Stanford researchers
8. Agilent Technologies releases automated literature search tool for biology researchers
9. Self-assembled nano-sized probes allow Penn researchers to see tumors through flesh and skin
10. Yale researchers identify molecule for detecting parasitic infection in humans
11. US life expectancy about to decline, researchers say
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: researchers reverse memory loss mice

(Date:1/22/2015)... Inc. , a market leader of iris-based identity authentication solutions, ... the new role of Senior Vice President of Mobile and ... platforms and wearable solutions for EyeLock,s technologies. Gerber brings more ... industry to his role at EyeLock, with expertise in human ...
(Date:12/22/2014)... Dec. 22, 2014  The 2014 Holiday Season may be ... Market Intelligence reports that the long anticipated floodgates for ... intensifying demand for smart phones, tablets, and wearable mobile ... of 2.5 billion users with nearly 4.8 billion biometric ...
(Date:12/17/2014)... 2014 Research and Markets ( http://www.researchandmarkets.com/research/s6qzt5/samsung_galaxy_s5 ) ... S5 - Home Button Synaptics Fingerprint Sensor Technology Analysis" ... http://photos.prnewswire.com/prnh/20130307/600769 Based on a totally ... for the first time a fingerprint sensor in its ...
Breaking Biology News(10 mins):EyeLock Names Steve Gerber as Senior Vice President of Mobile and Wearables 2First Season of Holiday Shopping with Mobile Biometric Payments Wraps Up With a Present for Biometrics Industry: A Rosy Forecast for More Than 2 Billion Users of 4.8 Billion Mobile Biometric Devices by 2020 2Samsung Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology Analysis 2
... in molecular targeting, translational cancer research and cancer ... 17,000 scientists from around the world gather at ... the 2008 Annual Meeting of the American Association ... the meeting will include late-breaking clinical trial findings ...
... plant withers unproductively or thrives in salty conditions may ... mechanism that controls salt tolerance has been found in ... collaborating with an international team. Complex-N-glycan, a ... previously thought to have no helpful function for plant ...
... A. Strobel, Professor of Molecular Biophysics and Biochemistry, ... Award. The award is given by American ... outstanding scientific contributions made by young researchers early ... award lecture, titled Three Views of RNA Catalysis: ...
Cached Biology News:AACR annual meeting showcases developments in understanding and targeting cancers 2AACR annual meeting showcases developments in understanding and targeting cancers 3Salt-tolerant gene found in simple plant nothing to sneeze at 2Yale University's Strobel recognized for work on RNA 2
(Date:1/22/2015)... January 22, 2015 Pipette.com has added ... to their comprehensive portfolio of Eppendorf products. , The ... purchase a Centrifuge 5424/5424 R and receive the following:, ... Eppendorf Research plus or Eppendorf Reference 2 , ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Selexis SA, ... mammalian Research Cell Banks (RCBs) used for drug discovery ... Cell Banks will include Next-Generation Sequencing (NGS) ... architecture de-risks biologic manufacturing by ensuring the integrity of ...
(Date:1/22/2015)... Jan. 22. 2015  Varian Medical Systems (NYSE: VAR ... honored for its commitment to sustainability with inclusion on a ... the highest ranked healthcare equipment company among the Corporate Knights ... World Economic Forum at Davos, Switzerland . ...
(Date:12/24/2014)... 2014  United Therapeutics Corporation (NASDAQ: UTHR ) ... ) has submitted a pre-market approval application to the ... of Medtronic,s SynchroMed ® II implantable drug infusion ... United Therapeutics, Remodulin ® (treprostinil) Injection delivered intravenously ...
Breaking Biology Technology:Eppendorf Announces Promotional Bundle Which Includes: Eppendorf Centrifuge 5424, 3-Pack of Pipettes, and Tips - Available Now at Pipette.com 2Selexis Generated Research Cell Banks Now Fully Sequenced Using Next-Generation Sequencing 2Varian Honored Among World's 100 Most Sustainable Corporations 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 3United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 4
... AKRON, Ohio , June 16 On Wednesday, June 23 ... promises to inspire renewed hope for new jobs in Ohio . ... will share their insight on innovation, global commerce and the new skills needed ... www.ohio.com/jobgrowth . , , , ...
... and SAN DIEGO , June 16 ... Biosciences, Inc. (Nasdaq: NBIX ) today announced that ... and commercialize elagolix for the treatment of endometriosis-related pain. ... antagonist, which has recently completed a phase IIb study ...
... ... in a new denture retention system procedure that can add 20% profit to a dental practice. ... (PRWEB) June 16, 2010 -- The ... new denture retention system procedure that can add 20% profit to a dental practice the ...
Cached Biology Technology:Free Web Cast On Fueling Ohio's New Job Growth 2Abbott and Neurocrine Announce Global Agreement to Develop and Commercialize Elagolix for the Treatment of Endometriosis 2Abbott and Neurocrine Announce Global Agreement to Develop and Commercialize Elagolix for the Treatment of Endometriosis 3Abbott and Neurocrine Announce Global Agreement to Develop and Commercialize Elagolix for the Treatment of Endometriosis 4Abbott and Neurocrine Announce Global Agreement to Develop and Commercialize Elagolix for the Treatment of Endometriosis 5Summit Dental Institute Offers A Hands-On One-Day Imtec MDI Mini Dental Implant Certification Course For Dentists 2Summit Dental Institute Offers A Hands-On One-Day Imtec MDI Mini Dental Implant Certification Course For Dentists 3Summit Dental Institute Offers A Hands-On One-Day Imtec MDI Mini Dental Implant Certification Course For Dentists 4
... This special concentrated jetSI 10 nM is ... into mouse brain as described in: Z. ... C. Giovannangeli, J.-P. Behr, and B.-A. Demeneix. ... expression in the mouse brain at picomolar ...
... jetSI-ENDO-FluoF is a ... nm; emission at 520 nm), ... These reagents are used to ... investigate the intracellular delivery and ...
... R&D Systems Cell and Tissue Staining ... in a broad range of histological and ... with primary IgG antibodies manufactured by either ... detection is based on the formation of ...
... covers a wide range of hands-on techniques ... researchers in all areas of protein chemistry ... books preface illustrates just how valuable this ... The chapters introduce the theoretical background of ...
Biology Products: