Navigation Links
U-M scientists identify major psoriasis susceptibility gene

University of Michigan scientists have found a common genetic variation in an immune system gene that makes people much more likely to develop psoriasis ?a disfiguring inflammatory skin disease.

Named PSORS1 (SORE-ESS-1), for psoriasis susceptibility 1, the gene is the first genetic determinant of psoriasis to be definitively identified in a large clinical study. Its discovery could lead to new, more effective treatments for psoriasis without the risks and side-effects of current therapies.

The gene's causative role in psoriasis was demonstrated in a University of Michigan Medical School study of 2,723 people from 678 families in which at least one family member had the disease.

Results of the U-M study ?the most comprehensive analysis of a psoriasis gene to date ?will be published in the May 2006 issue of the American Journal of Human Genetics.

Psoriasis is a chronic disease that affects about 2 percent of the U.S. population. People with psoriasis develop thick, flaky white patches on their skin and scalp. The disease is disfiguring and can have a negative effect on quality of life. About 25 percent of people with psoriasis eventually develop psoriatic arthritis, which can be severe.

Unlike diseases caused by a mutation in just one gene, psoriasis is what scientists call a multi-factorial disease. This means that people must inherit several disease-related genes, plus be exposed to one or more environmental triggers, in order to get psoriasis.

"For every individual with psoriasis who carries the PSORS1 gene, there are 10 other people with the gene who don't get psoriasis," says study director James T. Elder, M.D., Ph.D., a professor of dermatology and of radiation oncology in the U-M Medical School and the Ann Arbor VA Healthcare System.

"It's as if you are pushing a shopping cart down the aisle at the grocery store and putting genes in your cart," Elder adds. "There are several different brands of each gen
'"/>

Source:University of Michigan Health System


Page: 1 2 3 4

Related biology news :

1. Wisconsin scientists grow critical nerve cells
2. UCSB scientists probe sea floor venting to gain understanding of early life on Earth
3. UAB scientists discover the origin of a mysterious physical force
4. Fox Chase Cancer Center scientists identify immune-system mutation
5. Weizmann Institute scientists develop a new approach for directing treatment to metastasized prostate cancer in the bones.
6. U-M scientists find genes that control growth of common skin cancer
7. UCLA scientists transform HIV into cancer-seeking missile
8. RNA project to create language for scientists worldwide
9. Carnegie Mellon scientists develop tool that uses MRI to visualize gene expression in living animals
10. To control germs, scientists deploy tiny agents provocateurs
11. Leprosy microbes lead scientists to immune discovery
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: scientists identify major psoriasis susceptibility gene

(Date:7/22/2014)... A probiotic that prevents obesity could be on ... in the gut inhibit weight gain, insulin resistance ... in mice, Vanderbilt University investigators have discovered., "Of ... human," said senior investigator Sean Davies, Ph.D., assistant ... of the negative consequences of obesity in mice, ...
(Date:7/22/2014)... A research team from the National Institute of ... Clinic, has demonstrated a dramatically improved technique for ... molecular vibration "signatures." The new NIST technique is ... Raman spectroscopy, but one that delivers signals that ... Raman scattering, and 100 times stronger than obtained ...
(Date:7/22/2014)... Highly purified crystals that split light with uncanny ... optics and, potentially, computers that manipulate light instead ... techniques, such as etching them with a precise ... expensive. , Now, researchers at Princeton and Columbia ... allow scientists to customize and grow these specialized ...
Breaking Biology News(10 mins):Vanderbilt study shows therapeutic bacteria prevent obesity in mice 2Enhanced NIST instrument enables high-speed chemical imaging of tissues 2Enhanced NIST instrument enables high-speed chemical imaging of tissues 3Technique simplifies the creation of high-tech crystals 2Technique simplifies the creation of high-tech crystals 3
... research by a University of Alberta archeologist may lead ... our ancestors left Africa. U of A researcher ... region of southern Tanzania yielded fossils and other evidence ... sapiens. Her research, recently published in the journal ...
... Alto-based Lyncean Technologies, Inc., today announced its first sale ... source employing state-of-the-art laser-beam and electron-beam technology. ... by researchers from the newly-formed Center for Advanced Laser ... Ludwig Maximilians University of Munich (LMU) and the Technical ...
... A University of Oklahoma-led study has demonstrated that ancient ... The microbiomes from ancient people have broad reaching implications ... what good bacteria might have been lost as a ... aseptic practices. Cecil M. Lewis Jr., professor of ...
Cached Biology News:Tracing humanity's African ancestry may mean rewriting 'out of Africa' dates 2Tracing humanity's African ancestry may mean rewriting 'out of Africa' dates 3Lyncean Technologies Inc. sells Compact Light Source to Munich biomedical-imaging research center 2OU study suggests the bacterial ecology that lives on humans has changed in the last 100 years 2
(Date:7/22/2014)... CTD Holdings, Inc. (OTCQB:CTDH), a manufacturer ... cosmetics, and other markets, announced today that it has ... qualified private investors led by Novit L.P., an investment ... transaction involved the signing of a Securities Purchase Agreement ... Stock at a price per share of $1.00, resulting ...
(Date:7/22/2014)... 22, 2014 Automated cell culture systems ... of cell culture. They allow production of optimum cells ... researchers in drug discovery and industries and biopharmaceutical companies. ... production, iPSC research, cryobanking, cell-based assays, and cellular expression ... , Analysts forecast the Global Cell Culture market ...
(Date:7/22/2014)... Wisconsin (PRWEB) July 22, 2014 ... in attendance at the 2014 NCSL International Workshop ... Booth #423 will feature CONDEC pressure instrumentation, OIML ... weights, and the new, customized sets, Essential Weights™. ... to promote cooperative efforts in solving the common ...
(Date:7/22/2014)... (PRWEB) July 22, 2014 The ... clear and concise visual representation of history, migration, and ... was always regaled by family history stories stemming from ... as the "old country." Pictures and 8mm home movies ... side of the family, and Steve ordered a test ...
Breaking Biology Technology:CTD Holdings Closes $1.725 Million Private Placement 2CTD Holdings Closes $1.725 Million Private Placement 3Global Cell Culture Market to Grow at 10.27% CAGR by 2018 Forecasts a New Research Report ReportsnReports.com 2Global Cell Culture Market to Grow at 10.27% CAGR by 2018 Forecasts a New Research Report ReportsnReports.com 3Global Cell Culture Market to Grow at 10.27% CAGR by 2018 Forecasts a New Research Report ReportsnReports.com 4Rice Lake Weighing Systems Showcases Metrology Solutions for the 2014 NCSL International Workshop & Symposium 2DNA Test from DNA Spectrum Shows Heritage Like a Map of the Past 2DNA Test from DNA Spectrum Shows Heritage Like a Map of the Past 3DNA Test from DNA Spectrum Shows Heritage Like a Map of the Past 4
... Successful internal brand building requires more than a marketing ... people in the organization (HR managers, senior executives and ... this case, the employee experience) play a vital role ... for marketing-style campaigns alone to work. , ,Be ...
... Ventures in Entrepreneurship program is the WAVE of the future ... Cox, Director of the Weinert School of Entrepreneurship ... lags behind in Wisconsin. It is a state that has ... going on here at the university, we have WARF handling, ...
... unit of General Electric Company, announced today that it ... Administration to begin marketing its new 3.0 Tesla ultra-short ... combines the increased speed and higher resolution of an ... found on premium 1.5 Tesla systems. , ,Signa EXCITE ...
Cached Biology Technology:Employer Brands Require More Than Slick Marketing 2WAVE of the Future? 2WAVE of the Future? 3GE Medical Systems Receives FDA Clearance for New MRI System 2
Request Info...
Recombinant Equine TNF-alpha/TNFSF1A, CF...
Recombinant Equine IL-4, CF...
actin from rabbit muscle Cell Biology Cytoskeletal Probes Actin and Actin Probes...
Biology Products: