Navigation Links
U-M scientists find genes that control growth of common skin cancer

Scientists at the University of Michigan's Comprehensive Cancer Center and the National Cancer Institute have identified genes that promote the growth and recurrence of skin cancer. Andrzej Dlugosz, M.D., a professor of dermatology in the U-M Medical School, and colleagues at the University of Michigan and the National Cancer Institute examined the functions of the Hedgehog (Hh) signaling pathway in basal cell carcinoma ?the most common form of cancer ?and uncovered a subset of tumor cells that were resistant to inhibition of the Hedgehog pathway. The new finding has important implications for the treatment of this widespread disease. Their report will be published in the Jan. 15 issue of Genes & Development, but is available now on the journal's Web site.

Basal cell carcinoma (BCC) affects over 1,000,000 Americans each year and frequently develops on sun-exposed sites, such as the face. Surgical removal of BCCs is an effective approach to treating these cancers, which generally have a slow growth rate and seldom spread or metastasize. However, untreated BCCs can cause extensive local tissue damage, and surgical procedures can produce significant scarring in cosmetically sensitive locations, such as the face. The Hedgehog signaling pathway plays a key role in normal development, and its dysfunction has been implicated in a number of different human diseases and neoplasms, including BCCs in skin and cancers arising in brain, lung, prostate, pancreas and other gastrointestinal organs. Dlugosz and colleagues focused on the function of uncontrolled Hh pathway signaling in the growth of BCC. The investigators used genetically engineered mice in which they could manipulate expression of an Hh pathway component, called Gli2 , effectively turning it on or off at will in the skin. As expected, expression of Gli2 resulted in BCC formatio
'"/>

Source:U-M Medical School


Page: 1 2 3

Related biology news :

1. Wisconsin scientists grow critical nerve cells
2. UCSB scientists probe sea floor venting to gain understanding of early life on Earth
3. UAB scientists discover the origin of a mysterious physical force
4. Fox Chase Cancer Center scientists identify immune-system mutation
5. Weizmann Institute scientists develop a new approach for directing treatment to metastasized prostate cancer in the bones.
6. UCLA scientists transform HIV into cancer-seeking missile
7. RNA project to create language for scientists worldwide
8. Carnegie Mellon scientists develop tool that uses MRI to visualize gene expression in living animals
9. To control germs, scientists deploy tiny agents provocateurs
10. Leprosy microbes lead scientists to immune discovery
11. Integration of Agilents MS technology, Proteome Systems software to help scientists in proteomics research
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: scientists find genes that control growth common skin cancer

(Date:12/15/2014)... , Dec. 12, 2014 Research and Markets ... the "Global Facial Recognition Market 2015-2019" report ... Facial recognition is a technology used ... the overall facial feature of a person such as ...
(Date:12/11/2014)... 10, 2014  Data Sciences International (DSI), the global ... new series of digital telemetry implants to meet ... series, part of the PhysioTel™ Digital platform, was ... physiologic data when incorporating functional endpoints into repeat-dose ...
(Date:12/10/2014)... 9, 2014 CIE San Diego has launched an innovative ... that enhances care coordination among social service and care providers ... second $1 million grant from the Alliance Healthcare Foundation to ... be recognized as a "Live Well San Diego" partner on ...
Breaking Biology News(10 mins):Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3New telemetry implants expected to change how large animal toxicology studies are conducted 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 3Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 4
... in on finding an effective bait to get ahead ... is now killing not only lodgepole pine forests, but ... Research Chair in Forest Entomology in the University of ... emitted by the pest in North America,s lodgepole and ...
... multi-model-based assessment of so-called Durban Platform scenarios, conducted by ... Institute for Climate Impact Research (PIK) and the Fondazione ... is the current negotiation track at the Warsaw climate ... by 2015 to come into effect in 2020. ...
... new research shows that the Plasmodium vivax ... in 2010, may be "rapidly evolving" to overcome the natural ... Africans, scientists reported today at the annual meeting of the ... In large swaths of sub-Saharan Africa, some 95 ...
Cached Biology News:Bait research focused on outsmarting destructive beetle 2Success of climate talks vital for 2°C target 2Success of climate talks vital for 2°C target 3New research finds potential risk for millions in Africa believed resistant to vivax malaria 2New research finds potential risk for millions in Africa believed resistant to vivax malaria 3New research finds potential risk for millions in Africa believed resistant to vivax malaria 4
(Date:1/22/2015)... (PRWEB) January 22, 2015 Crystal Diagnostics (CDx) ... that it has received AOAC-PTM Certifications for the six non-O157 ... and O145; collectively referred to as STEC or the “Big-6”) ... colony forming unit (cfu) per 325 g of raw ground ...
(Date:1/22/2015)... 22, 2015 Dr. Greg Leyer of UAS ... Scripps Natural Supplements Pre-Conference seminar on probiotics in San Diego, ... annual continuing education conference for health care professionals. This year’s ... topic of probiotics in health. Dr. Leyer spoke about the ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Diagenode, ... such as the Bioruptor® and complete solutions for ... for chromatin immunoprecipitation, alleviating the need for manual ... controls needed for ChIP of histones or transcription ...
(Date:1/22/2015)... 22. 2015  Varian Medical Systems (NYSE: VAR ), ... for its commitment to sustainability with inclusion on a prestigious ... highest ranked healthcare equipment company among the Corporate Knights Global ... Economic Forum at Davos, Switzerland . ...
Breaking Biology Technology:Crystal Diagnostics Awarded AOAC-PTM Accreditation for the Rapid Detection of “Big 6” E.coli Food Pathogens 2Diagenode Launches Unique Semi-Automated Solution for Chromatin Immunoprecipitation 2Varian Honored Among World's 100 Most Sustainable Corporations 2
... In a move designed to give Wisconsin a competitive ... a partnership agreement with the Wisconsin Alumni Research ... research at non-profit and academic institutions in Wisconsin a ... held by WARF. , ,In what the administration called ...
... in the first televised debate in Wisconsin's campaign for governor ... asked Gov. Jim Doyle and challenger Mark ... Beene, who had worked for Pabst Brewery before its 1997 ... closing all over the place" - and he wanted to ...
... Wis. - The Center for International Blood and ... Wisconsin has won a contract worth $6,180,029 to collect ... cell transplants that use cells from bone marrow or cord ... part of the U.S. Department of Health and Human ...
Cached Biology Technology:Doyle, WARF announce partnership to lure stem cell companies 2Doyle, WARF announce partnership to lure stem cell companies 3Candidates' sparring over jobs focuses debate on right issue 2Candidates' sparring over jobs focuses debate on right issue 3Medical College to build $6M transplant database 2
... Kinase (PNK) catalyzes the transfer of ... 5'-hydroxyl of single- and double-stranded DNA, ... also removes the 3'-phosphate from 3'-phosphoryl ... 5'-diphosphates to form a 3'-hydroxyl group. ...
MOUSE ANTI GTP BINDING PROTEIN...
We offer solid and solution phase peptide synthesis including a whole range of modifications. Please send the details of your peptide synthesis need to info@rpeptide.com...
Maxi XL Hybridization Oven for Extra Large bottles. 6 bottle (70 mm) rotisserie + shaker tray available for simultaneous use. Includes linear and orbital shaker trays, 4 extra large bottles, pack o...
Biology Products: