Navigation Links
U-M researchers use nanoparticles to target brain cancer

Tiny particles one-billionth of a meter in size can be loaded with high concentrations of drugs designed to kill brain cancer. What's more, these nanoparticles can be used to image and track tumors as well as destroy them, according to researchers at the University of Michigan Comprehensive Cancer Center.

Researchers incorporated a drug called Photofrin along with iron oxide into nanoparticles that would target cancerous brain tumors. Photofrin is a type of photodynamic therapy, in which the drug is drawn through the blood stream to tumor cells; a special type of laser light activates the drug to attack the tumor. Iron oxide is a contrast agent used to enhance magnetic resonance imaging, or MRI.

"Photofrin goes into tumor blood vessels and collapses the vasculature, which then starves the tumor of the blood flow needed to survive. The problem with free photofrin therapy is that it can cause damage to healthy tissue. In our study, the nanoparticle becomes a vehicle to deliver the drug directly to the tumor," says study author Brian Ross, Ph.D., professor of radiology at the U-M Medical School and co-director of Molecular Imaging at the U-M Comprehensive Cancer Center.

Photofrin has been used to treat several types of cancer, including esophageal, bladder and skin cancers. It works by traveling through blood vessels until it reaches the vessels supplying blood to the tumor. When activated by light, the Photofrin collapses these blood vessels, starving the tumor of the blood it needs to survive.

Results of the study appear in the Nov. 15 issue of Clinical Cancer Research.

"Thinking outside the box is a must for developing brain cancer treatments. Drugs don't get into the brain when delivered in the normal way, which explains in part why some current treatments for brain tumors are generally not effective. Targeting the tumor vasculature with nanoparticles containing a payload will overcome these issues," says study author
'"/>

Source:University of Michigan Health System


Page: 1 2 3

Related biology news :

1. NYU researchers simulate molecular biological clock
2. Vital step in cellular migration described by UCSD medical researchers
3. ASU researchers finds novel chemistry at work to provide parrots vibrant red colors
4. UCSD researchers maintain stem cells without contaminated animal feeder layers
5. Why do insects stop breathing? To avoid damage from too much oxygen, say researchers
6. New protein discovered by Hebrew University researchers
7. First real-time view of developing neurons reveals surprises, say Stanford researchers
8. Agilent Technologies releases automated literature search tool for biology researchers
9. Self-assembled nano-sized probes allow Penn researchers to see tumors through flesh and skin
10. Yale researchers identify molecule for detecting parasitic infection in humans
11. US life expectancy about to decline, researchers say
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: researchers use nanoparticles target brain cancer

(Date:8/27/2014)... century-old museum specimens hold clues to how global climate change ... kill trees and the news is not good. , ... and maple trees in warmer urban areas, which raises the ... says Dr. Elsa Youngsteadt, a research associate at NC State ... "More scale insects would be a problem, since scales can ...
(Date:8/26/2014)... Louis have developed algorithms to identify weak spots in ... The technology, which needs to be refined before it ... minor strains and tiny injuries in the body,s tissues ... available online Aug. 27 in the Journal of ... the nexus of the physical and life sciences. , ...
(Date:8/26/2014)... of harmful bacteria, biofilms make the treatment of ... biofilm pose a significant health risk due to ... biofilm-protected bacteria account for some 80 percent of ... to 1,000 times more resistant to antibiotics than ... have stumbled onto a magic bullet," said David ...
Breaking Biology News(10 mins):Museum specimens, modern cities show how an insect pest will respond to climate change 2New technology may identify tiny strains in body tissues before injuries occur 2New technology may identify tiny strains in body tissues before injuries occur 3Breakthrough antibacterial approach could resolve serious skin infections 2Breakthrough antibacterial approach could resolve serious skin infections 3
... , Journal of Visualized Experiments , details the ... polymer, SurgiLux, was developed by scientists at the University ... from chitin, which is found in fungal cell walls ... allows SurgiLux to form low energy bonds between the ...
... Institute for Medical Research has been awarded a $1 ... which is administered by the National Institute for Occupational ... for Disease Control and Prevention (CDC), the National Institute ... comprehensively study the overall physical, mental and socioeconomic impact ...
... Manoel Manghi from Toulouse University in France and his colleagues ... to a double stranded molecule of DNA when it is ... be published in EPJ E . Instead of using ... settings, the authors focused on using a theoretical model to ...
Cached Biology News:New bio-adhesive polymer demonstrated in JoVE 2Feinstein Institute receives $1 million grant to study impact of World Trade Center attacks on responders 2
(Date:8/26/2014)... , Aug. 26, 2014 Albany Molecular ... that William S. Marth , President and Chief ... Stanley Global Healthcare Conference on Monday, September 8, 2014 ... audio webcast of the presentation can be accessed at ... The webcast will be archived for 90 ...
(Date:8/26/2014)... Boston, MA (PRWEB) August 26, 2014 ... to manage core research facilities , the ... of Kansas Cancer Center have chosen iLab Solutions' ... and effectively increase productivity. , "We are ... Center and KU Cancer Center signed on with ...
(Date:8/26/2014)... Historically, drug development has faced ... to grow – high attrition rate, low productivity, ... high regulatory hurdles and increasing concern about ... that the traditional business model of pharmaceutical companies ... seeking to find better ways to reduce operational ...
(Date:8/26/2014)... 2014 Spartan Bioscience today announced ... of Business Development. Mr. Shah is responsible for ... System in the United States and international ... opportunities and strategic initiatives for the company’s rapid ... Mr. Shah was the Global Marketing Product Manager ...
Breaking Biology Technology:The University of Kansas Medical Center and The University of Kansas Cancer Center Select iLab Solutions Web-based Software to Streamline Operations 2The University of Kansas Medical Center and The University of Kansas Cancer Center Select iLab Solutions Web-based Software to Streamline Operations 3Transitioning from Bench into Clinical Phase, new webinar hosted by Xtalks 2Spartan Bioscience Names Charudutt Shah as Director of Business Development 2
... today announced that Pat Basu, M.D., M.B.A. , ... as Chief Medical Officer. Dr. Basu has just completed ... a White House Fellow, America,s most prestigious and selective ... will play a critical role in advancing vRad,s efforts, ...
... Sequenom, Inc. (NASDAQ: SQNM ), a life ... the launch of its iPLEX ADME PGx panel developed ... distribution, metabolism, and excretion (ADME). This Research Use Only ... polymorphisms (SNP), insertions and deletions (INDELS) and copy number ...
... HILL, MA -- Boston College researchers have discovered two ... chemical vapor deposition, finding a disorderly tangle of tube ... nanoscopic tubes, according to a report in the latest ... using a thin layer of catalyst, Professor of Physics ...
Cached Biology Technology:vRad Adds White House Fellow, Dr. Pat Basu, to Its Leadership Teams 2Sequenom Introduces iPLEX® ADME PGx Panel on MassARRAY® System 2Sequenom Introduces iPLEX® ADME PGx Panel on MassARRAY® System 3Boston College Researchers discover 2 early stages of carbon nanotube growth 2
... can be induced prior to DNA purification ... stability of single-copy BACs with the high ... vectors. The kits provide the linearized vector ... screening system) necessary to create a 10X ...
...
... 3T3 cells were cultured in DMEM with 4 ... of growth. In order to keep the ... in acetone-methanol. The cells are arrayed on ... each wells surface specifically treated to enhance cellular ...
... Systems provide rapid, precise localization of ... frozen or paraffin-embedded tissue, cytospins and ... facilitate double or triple labeleing experiments, ... with primary antibodies of different animal ...
Biology Products: