Navigation Links
U-M researchers take new approach to defeating Gram-negative bugs

Ronald Woodard's team set out looking for a way to kill a stubborn type of bacteria and they succeeded---but not in the way he expected.

"We didn't get there the way we thought we'd get there, but in the end, we were right," said Woodard, chair of medicinal chemistry at the University of Michigan College of Pharmacy.

Woodard is senior author of an article describing way he and his research team genetically modified Escherichia coli bacteria, known as a Gram-negative bug, to weaken its defenses. That article appears in the recently released inaugural issue of the American Chemical Society's journal ACS Chemical Biology.

Some of the better-known Gram negatives are salmonella, gonorrhea, cholera and meningicoccal meningitis, along with the bacteria that caused the black plague.

Woodard and his collaborators worked on E. coli in part because it is one of the more common Gram-negative bacteria, and it is considered by researchers the gold standard of Gram-negative bacteria.

After their genetic modifications, E. coli was killed with just a fraction of the antibiotic dose typically needed. It was 512 times more susceptible to Rifampin, 256 times more vulnerable to Novobiocin, and eight times more susceptible to Bacitracin, suggesting doses could be dramatically cut and still be effective, Woodard said. Antibiotics typically only effective against Gram-positive bacteria could work against Gram-negative bacteria if a compound can be designed to mimic this genetic modification, Woodard said.

Also, E. coli can typically withstand the bile salts found in the human digestive tract, but by weakening it, Woodard's team found E. coli would die in the presence of normal levels of bile salts to which the bacteria would be exposed in the human gut.

Besides differing in how they respond to Gram's coloring test, Gram-positive and Gram-negative bacteria look different. Gram-positive cells are smooth on the outside, while Gram-negati
'"/>

Source:University of Michigan


Page: 1 2 3

Related biology news :

1. NYU researchers simulate molecular biological clock
2. Vital step in cellular migration described by UCSD medical researchers
3. ASU researchers finds novel chemistry at work to provide parrots vibrant red colors
4. UCSD researchers maintain stem cells without contaminated animal feeder layers
5. Why do insects stop breathing? To avoid damage from too much oxygen, say researchers
6. New protein discovered by Hebrew University researchers
7. First real-time view of developing neurons reveals surprises, say Stanford researchers
8. Agilent Technologies releases automated literature search tool for biology researchers
9. Self-assembled nano-sized probes allow Penn researchers to see tumors through flesh and skin
10. Yale researchers identify molecule for detecting parasitic infection in humans
11. US life expectancy about to decline, researchers say
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: researchers take new approach defeating Gram negative bugs

(Date:7/22/2014)... some point, most kids will hear that drinking milk helps make ... But do these messages foster the idea that if something is ... new study in the Journal of Consumer Research , when ... to eat it. , "We predicted that when food is presented ... achieve a goal such as learning how to read or count, ...
(Date:7/22/2014)... LA -- Nancy Buccola, MSN, APRN, PMHCNS-BC, CNE, ... Sciences Center New Orleans School of Nursing, contributed ... of genetic material associated with schizophrenia and also ... and schizophrenia. The study, Biological insights from 108 ... 2014 in Nature , available at http://www.nature.com/nature/journal/vaop/ncurrent/full/nature13595.html., ...
(Date:7/22/2014)... meerkats which sees them prevent their daughters from breeding, ... study. , Research into the desert creatures which live ... helpers shows that the alpha female can flourish when ... shows how this way of life, also found in many ... its sinister side. , Dominant meerkats control breeding within ...
Breaking Biology News(10 mins):LSUHSC contributes to work identifying new DNA regions associated with schizophrenia 2
... intervention taught by teen mentors in Appalachian elementary schools ... lifestyle changes among the younger students learning the curriculum, ... taught the same lessons by adults in a traditional ... The results of the eight-week clinical trial conducted by ...
... few years ago, the idea of 3-D printing a major ... eye North Carolina as a national hub for human organs ... Medical advances in biotechnology seem to be coming faster ... how society should handle ethical, legal and moral considerations. ...
... a school classroom chemistry experiment, in which beautiful plant-like structures ... real-world scientific experiments that aim to shed light on the ... a "battery" that could have kick-started life are the topic ... & Engineering News . C&EN is the weekly newsmagazine of ...
Cached Biology News:Teen mentors inspire healthier choices in younger children 2Teen mentors inspire healthier choices in younger children 3Teen mentors inspire healthier choices in younger children 4'After the Genome' tackles tough questions about medicine, miracles and morality 2'After the Genome' tackles tough questions about medicine, miracles and morality 3
(Date:7/22/2014)... 22, 2014 Quorum Review IRB, the industry ... large clinical trials called Quick Step™ . The offering ... address the research industry’s need for seamless study start-up with ... available for studies planning 50 or more North American investigator ... North American site count of 80 or more. Qualifying studies ...
(Date:7/22/2014)... 22, 2014 Biofeedback – ... (ADHD) is diagnosed, selecting medication to best treat it ... brain patterns by using electroencephalography (EEG) can help predict ... lower the risk of adverse drug events. , The ... in the current issue of the journal Biofeedback ...
(Date:7/21/2014)... Vernon Hills, IL (PRWEB) July 21, 2014 ... remote control, and simple programming, the new ... Pump Head is easy to operate for ... between cycles for hands-free dispensing. The batch count ... the cumulative volume or totalizer tracks amount dispensed ...
(Date:7/21/2014)... 2014  Mike Patterson, CEO of Graphene Frontiers, ... Series Seed B funding to finance production of ... life science, defense, intelligence, and environmental industries.  A ... round and was joined by R2M Investments.  Return ... , "This round of funding will ensure Graphene ...
Breaking Biology Technology:Quorum Review IRB Launches New Quick Step™ Service for Large Clinical Trials 2Quorum Review IRB Launches New Quick Step™ Service for Large Clinical Trials 3Analyzing Brain Patterns with EEG Can Help Predict Effective Use of Medication 2Analyzing Brain Patterns with EEG Can Help Predict Effective Use of Medication 3New Easy-View Cole-Parmer Digital Gear Pump Drive Makes Performance Monitoring Effortless 2Global Graphene Manufacturing Leader, Graphene Frontiers, Receives Series Seed B Funding To Assure Production Of The Next Generation Of Biological And Chemical Sensor Technology 2
... What one thing, if done extremely well, is a ... organizations? And what, if done poorly, is an enormous ... delegate will have a direct impact on how effectively ... article I will share some delegation tips on how ...
... has launched a new service to help the Wisconsin business ... Corporate Relations and University Communications developed UW Business News ... events and links to publications. It is available online or ... one place ... all the sorts of information that would ...
... Summary and conclusion , ,Are your projects still late? ... less than promised? Unfortunately, the answer is probably yes. , ... neednt be the case. Think about it you learn new ... same mistake twice. Youve gone to class. Youve learned the ...
Cached Biology Technology:Fire up your marketing by delegating 2Wire service to connect UW-Madison to business 2Project Performance: Is your project late? Over budget? 2Project Performance: Is your project late? Over budget? 3
... DH-2000, but comes with a shutter (controlled via ... Hz) The DH-2000 Deuterium Tungsten ... deuterium and tungsten halogen light sources in a ... a powerful, stable output from 215-200 nm. In ...
... in g per ml and is determined from ... of a 1 mg per ml solution. ... agglutinate a 2% suspension of human blood group ... C. Preparation Note: Affinity purified by ...
... MSD Security ChemStation is ... software application for data ... library searching and reporting, ... of data security, integrity, ...
... save space and organize gloves, ... other garb. They are the ... small parts used in labs, ... Open-slot design for easy cleaning. ...
Biology Products: