Navigation Links
U-M researchers discover gene switched off in cancer can be turned on

d in certain cancer cell lines. They found no mutations to the gene but rather that it was just silent – essentially like a switch that had been turned off. Knowing that a class of drugs called histone deacetylase inhibitors, or HDAC inhibitors, can affect gene expression, the researchers applied these drugs to the cells and found the BRM expression could be restored – like flipping the switch back on.

While the existing HDAC inhibitors did return BRM expression, the effect was short-lived. Once the drugs were taken away, BRM expression decreased.

“The HDAC inhibitors are not the perfect answer, but in principle this tells us we can turn our gene back on. If we can turn the gene back on, it may not be a cure for cancer, but it could slow it down or make it responsive to existing drugs,” Reisman says.

The researchers targeted lung cancer cell lines in particular, although they found similar results in a variety of other cancer cell lines tested. A potential target to treat lung cancer is particularly crucial as the death rate from lung cancer has not changed in 30 years. Newer treatments are much less toxic and extend lives by months, but the same people who died from lung cancer 30 years ago, would still succumb to this disease today.

Targeted therapies have dramatically improved cancer care in recent years, because they thwart the specific genes which drive the development and progress of cancers. They typically have few toxic side effects, unlike traditional chemotherapy, making them more tolerable as a long-term treatment or in combination with other drugs.

“Tumors are not the same from one person to the next, and even the cells within a single tumor are not the same. Giving a single drug or drug combination to 500 people is setting ourselves up for failure, much like a one-size-fits-all clothing store would never succeed,” Reisman says.

“Targeted therapies are now opening the door, because they are ess
'"/>

Source:University of Michigan Health System


Page: 1 2 3

Related biology news :

1. NYU researchers simulate molecular biological clock
2. Vital step in cellular migration described by UCSD medical researchers
3. ASU researchers finds novel chemistry at work to provide parrots vibrant red colors
4. UCSD researchers maintain stem cells without contaminated animal feeder layers
5. Why do insects stop breathing? To avoid damage from too much oxygen, say researchers
6. New protein discovered by Hebrew University researchers
7. First real-time view of developing neurons reveals surprises, say Stanford researchers
8. Agilent Technologies releases automated literature search tool for biology researchers
9. Self-assembled nano-sized probes allow Penn researchers to see tumors through flesh and skin
10. Yale researchers identify molecule for detecting parasitic infection in humans
11. US life expectancy about to decline, researchers say
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: researchers discover gene switched off cancer can turned

(Date:7/27/2014)... of the largest prevalence studies to date, researchers from ... estimates for the hepatitis C virus (HCV). Findings published ... the Study of Liver Diseases, indicate that genotype 1 ... patients infected of which one-third reside in East Asia. ... the next most prevalent, followed by genotypes 2, 4, ...
(Date:7/27/2014)... N.C. -- Microorganisms like bacteria and fungi can evade ... antibiotics or antifungal drugs. These permanent mutations were once ... to evolve. Now a new study has shown that ... -- known as epimutations -- to gain the benefits ... new mechanism was discovered in a fungus called Mucor ...
(Date:7/27/2014)... Cancer Institute have found that targeting a molecule in ... according to research published in Nature today ... Queen Mary University of London, have found that a ... to repair itself after chemotherapy or radiotherapy, which kill ... FAK from blood vessels that grew in melanoma or ...
Breaking Biology News(10 mins):Hepatitis C virus genotype 1 is most prevalent worldwide 2Scientists discover new, noncommittal mechanism of drug resistance 2Scientists discover new, noncommittal mechanism of drug resistance 3New drug target can break down cancer's barrier against treatment 2
... A team of international molecular scientists, led by a ... which cells communicate change for example their location during ... adjacent cells. The discovery sheds new light on cell ... to combat diseases such as cancer, rheumatoid arthritis and Alzheimer,s ...
... the behaviour of invasive ants in northern Australia, finding ... networks, CSIRO has recognised the outstanding work of some ... in Melbourne. The CSIRO Medals are awarded each year ... contributions to the organisation. Awarded since 1985, the CSIRO ...
... of altruism has long puzzled researchers and has mainly ... now because I expect there to be some long-term ... at the Primate Research Institute (PRI) and the Wildlife ... altruistically help conspecifics, even in the absence of direct ...
Cached Biology News:Milestone discovery in cell behaviors 2CSIRO medal winners 2CSIRO medal winners 3Chimpanzees help each other on request but not voluntarily 2
(Date:7/25/2014)... Pa. , July 25, 2014 /PRNewswire-iReach/ -- ... and consulting for global corporations operating in highly ... host its first annual Global User Group Conference, ... historic Philadelphia, Pennsylvania at ... - http://photos.prnewswire.com/prnh/20140724/130263 This ...
(Date:7/24/2014)... July 24, 2014 Gain recognition ... Supply Chain of the biotech industry. Nominations are ... Awards, brought to you by the Bio ... of supply chain management professionals for the past ... stakeholders of the Biotech industry – Manufacturers, Service ...
(Date:7/24/2014)... Yung-Eun Sung has announced that they have developed ... which can be applied as high performance electrodes ... is both a group leader at the Center ... (IBS) and a professor at the Seoul National ... regards to the development of relative simplicity, scalablity, ...
(Date:7/24/2014)... 2014 Research and Markets has ... Proteomics Analytical Instruments Market 2014-2018" report to their ... Genomics is the study of the gene and ... structure and functions of proteomes or sets of proteins ... Genomics involves the mapping of genes and DNA sequencing ...
Breaking Biology Technology:Xybion Announces It Will Host International User Conference in Philadelphia 2Xybion Announces It Will Host International User Conference in Philadelphia 3Call for Submission: BSMA’s Supply Chain Management Innovation Awards 2Call for Submission: BSMA’s Supply Chain Management Innovation Awards 3Global Genomics and Proteomics Analytical Instruments Market 2014-2018: Key Vendors are Agilent, Bio-Rad , F. Hoffmann, La Roche, Illumina, PerkinElmer and Thermo Fisher Scientific 2
... /PRNewswire-Asia/ -- China Botanic Pharmaceutical Inc. (AMEX: CBP ... distributor of botanical products, bio-pharmaceuticals and traditional Chinese medicines ("TCM") ... ended July 31, 2011. Third - ... and Recent Events Net sales increased 33.6% ...
... Inc. (Nasdaq: SGMO ) announced today that ... overview of the company,s business strategy at 7:30 am ... 2011 Global Life Sciences Conference which will be held ... Nichol, M.B., Ch.B., Sangamo,s executive vice president of research ...
... Pa., Sept. 14, 2011 Tengion, Inc. (NASDAQ: ... Brian Davis, Vice President Finance and Chief Financial Officer of ... Conference on Monday, September 19, 2011, at 1:30 pm EDT. ... be accessed under "Calendar of Events" in the Investors section ...
Cached Biology Technology:China Botanic Pharmaceutical Reports Third-Quarter Fiscal Year 2011 Results 2China Botanic Pharmaceutical Reports Third-Quarter Fiscal Year 2011 Results 3China Botanic Pharmaceutical Reports Third-Quarter Fiscal Year 2011 Results 4China Botanic Pharmaceutical Reports Third-Quarter Fiscal Year 2011 Results 5China Botanic Pharmaceutical Reports Third-Quarter Fiscal Year 2011 Results 6China Botanic Pharmaceutical Reports Third-Quarter Fiscal Year 2011 Results 7China Botanic Pharmaceutical Reports Third-Quarter Fiscal Year 2011 Results 8Sangamo BioSciences Announces Presentation at the 2011 UBS Global Life Sciences Conference 2Tengion to Present at UBS Global Life Sciences Conference 2
... used to reveal two distinct antigens in ... a Zymed polymer double staining detection method ... same human cell or tissue sample with ... using two different primary antibodies from mouse ...
... situ detection of apoptosis and mitochondrial membrane ... an early indication of the initiation of ... as a collapse in the electrochemical gradient ... the change in the membrane potential (YD). ...
... FLUOstar OPTIMA is a fully automated ... life science labs in academia and ... measurement principles: Fluorescence Intensity ... Time-Resolved Fluorescence including DELFIATM ...
... CYCLES. An assay kit designed to detect ... PARP is an enzyme implicated in DNA ... is cleaved by caspase-3. Cleavage of PARP ... kDa is a hallmark of apoptosis. Each ...
Biology Products: