Navigation Links
Two-faced protein can stop metastasis or promote it, researchers say

A protein known to be a key component of the glue that holds cells together also is involved in breaking them apart and promoting their movement when tumors begin to spread to other parts of the body, researchers at Mayo Clinic have found.

The study, published in the Sept. 18 online issue of the Journal of Cell Biology, helps illuminate the very first steps involved in metastasis, the spread of cancer that makes the disease difficult to treat, and suggests that a future designer drug might be able to block the beginning of this dangerous process, or stop it once it starts.

"Our data show that this one protein, p120 catenin, is a key player in both suppressing invasion and promoting it," says the study's senior author, Panos Anastasiadis, Ph.D., a Mayo Clinic cancer researcher. "This is very exciting, because the findings open up a whole new field of discovery for novel therapeutics that should be applicable to most types of tumors."

Their laboratory study looks at how p120 catenin interacts with different cadherin cell adhesion proteins in cancer cells. Cadherin proteins go through a cell membrane, and on the outside, they act like Velcro, sticking to other cadherin proteins on adjacent cells. On the inside of the cell membrane, cadherins bind, chain-like, to catenins, and catenins, in turn, regulate a cell's shape and function.

The best understood cadherin is E-cadherin, which provides tight connections between epithelial cells, forming a strong barrier-like layer covering the inside of organs and body cavities and the outside skin of humans. "E-cadherin holds a human's cells and tissues together," Anastasiadis says.

The other cadherins featured in this study belong to a group that collectively is called "mesenchymal" cadherins, which provide a looser bond between the cells that sparsely populate the connective tissue. "Collagen usually provides the strength to the connective tissue, so tight cell-cell adhesion is not tha
'"/>

Source:Mayo Clinic, Jacksonville


Page: 1 2 3

Related biology news :

1. New, automated tool successfully classifies and relates proteins in unprecedented way
2. New binding target for oncogenic viral protein
3. Controversial drug shown to act on brain protein to cut alcohol use
4. Timing is everything: First step in protein building revealed
5. UWs Rosetta software to unlock secrets of many human proteins
6. Researchers find how protein allows insects to detect and respond to pheromones
7. Signaling protein builds bigger, better bones in mice
8. Ancient olfaction protein is shared by many bugs, offering new pest control target
9. Automatic extraction of gene/protein biological functions from biomedical text
10. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
11. Scientists develop new color-coded test for protein folding
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Two faced protein can stop metastasis promote researchers say

(Date:8/27/2014)... , Aug. 27, 2014 Reportlinker.com ... available in its catalogue: Law Enforcement ... http://www.reportlinker.com/p02316674/Law-Enforcement-Biometrics-Market-in-North-America-2014-2018.html About Biometrics ... individuals on the basis of their physical or ... of both physiological traits such as fingerprints, face ...
(Date:8/27/2014)... when it only requires nerve cells to rearrange existing ... to generate new patterns, a study of monkeys has ... through recordings of electrical activity of brain cell networks. ... of Health. , "We looked into the brain and ... outside the box," said Aaron Batista, Ph.D., an assistant ...
(Date:8/27/2014)... University of Utah biologist agan Sekercioglu, who campaigns ... that nation,s highest science prize, which is similar to ... among five researchers picked for 2014 the top awards ... Turkey. Three researchers won the Science Award and two ... is equivalent to the Science Award but for scientists ...
Breaking Biology News(10 mins):Law Enforcement Biometrics Market in North America 2014-2018 2Law Enforcement Biometrics Market in North America 2014-2018 3Law Enforcement Biometrics Market in North America 2014-2018 4Law Enforcement Biometrics Market in North America 2014-2018 5Scientists plug into a learning brain 2Scientists plug into a learning brain 3University of Utah biologist wins Turkey's top science prize 2
... In the search for life on Mars or any ... and oxygen to consider. Using Earth,s biogeochemical cycles as a ... as important for supporting life. As explored in studies published ... the Environment, the most basic elements work together to support ...
... 2011) -- For women seeking pregnancy by assisted reproductive technologies, ... the health of the uterus is more relevant than egg ... full gestation. This study, published in Fertility and ... for women with infertility diagnoses considering options for conceiving. ...
... Pasadena, Calif.The brainawake and sleepingis awash in electrical activity, ... neurons communicating with each other. In fact, the brain ... the neural circuits of scores of communicating neurons. The ... ,bug, of sorts, occurring during neural communication," says neuroscientist ...
Cached Biology News:Earth's life support systems discussed in an open-access special issue 2Uterine health more important than egg quality 2Uterine health more important than egg quality 3Neurobiologists find that weak electrical fields in the brain help neurons fire together 2Neurobiologists find that weak electrical fields in the brain help neurons fire together 3
(Date:8/28/2014)... Scientists, researchers, and technologists will converge in ... 2014 symposium. Marking its 46th year, the annual ... 14-17 September. The event is sponsored by SPIE, ... The premier conference for basic and applied issues which ... will engage researchers and engineers from numerous industries and ...
(Date:8/28/2014)... August 28, 2014 Supplementing their ... a promotion for Eppendorf Safe Lock Centrifuge ... purchase the highest quality tubes at an affordable ... for customers doing chemical, medical, pharmaceutical, and life ... are not regularly able to afford Eppendorf products. ...
(Date:8/27/2014)... Rhythm, a biopharmaceutical company developing peptide therapeutics that address ... disorders, announced today that it has filed a registration ... Exchange Commission (SEC) relating to the proposed initial public ... of shares to be offered and the price range ... Citigroup and Cowen and Company will act as ...
(Date:8/27/2014)... is how plants survive impact by the huge ... while using this energy for photosynthesis. The hypothesis ... blades quickly dissipate the energy throughout the entire ... DTU Physics have now managed to successfully ,film, ... contain light-absorbing proteins which play a role in ...
Breaking Biology Technology:Laser Damage to Draw Researchers, Engineers, Scientists to 46th Annual Conference 2Laser Damage to Draw Researchers, Engineers, Scientists to 46th Annual Conference 3Eppendorf Safe Lock Centrifuge Tube Promotion Now Available at Major Pipette Distributor Pipette.com 2Eppendorf Safe Lock Centrifuge Tube Promotion Now Available at Major Pipette Distributor Pipette.com 3Rhythm Files Registration Statement for Proposed Initial Public Offering 2DTU researchers film protein quake for the first time 2
... , , CINCINNATI, July ... global full-service clinical research organization, today appointed Stephen Cutler, PhD, ... Officer (COO) effective immediately. Dr. Cutler brings to Kendle more ... in the CRO and biopharmaceutical industries to position the Company ...
... 28 BioCryst Pharmaceuticals (Nasdaq: BCRX ) today ... released on Thursday, July 30, 2009. BioCryst will host ... Time to discuss the financial results and provide an update ... by Jon P. Stonehouse, President and Chief Executive Officer, Stuart ...
... ... Investors to Attend July 30 Debut , ... Los Angeles, CA (Vocus) - GreenHouse announced today that on ... system that turns organic waste into a high performance ethanol fuel for cars. ...
Cached Biology Technology:Kendle Appoints Stephen Cutler, PhD Senior Vice President and Chief Operating Officer 2Kendle Appoints Stephen Cutler, PhD Senior Vice President and Chief Operating Officer 3BioCryst Pharmaceuticals to Announce Second Quarter 2009 Financial Results on July 30, 2009 2GreenHouse Debuts the World's First E-Fuel MicroFuelerTM in Los Angeles 2GreenHouse Debuts the World's First E-Fuel MicroFuelerTM in Los Angeles 3
... NeuroLog System is a compact, versatile & modular ... of purposes including: Intracellular, Extracellular, Transducer & ... The NeuroLog Case & Power Supply unit (NL900D) ... Modules are not only powered by this unit, ...
37-1A9...
Porcine Coronary Artery Endothelial Cells (PCAEC) (>500,000 cells)...
Proliferin (N-14)...
Biology Products: