Navigation Links
Two designer drugs hit same lung cancer target, but only one is effective

lleagues wanted to determine whether Erbitux might be another option for NSCLC patients who carry the EGFR mutation. To test this idea, they treated lung cancer cell lines in the laboratory with Iressa and with Erbitux. They reported that both drugs blocked the excess signals in cells with normal EGFR, but only Iressa was significantly effective in those carrying a mutant EGFR.

"It tells us something about the difference in the drugs' ability to cause a regression of the cancer by shutting down the abnormally active growth signal receptor, EGFR," says Janne. "If you want to choose a way of inhibiting the mutant EGFR receptor, you would pull Iressa and Tarceva off the shelf, not Erbitux."

Iressa and Tarceva are known as small-molecule drugs that can be taken orally and block the part of the EGFR molecule that's located within the cell. In NSCLC, patients with the mutation often respond to both drugs, though only Tarceva has helped patients live slightly longer in clinical trials. Erbitux is a monoclonal antibody drug that binds to a portion of the EGFR receptor that extends outside the cell. This difference in action is the apparent explanation for why they performed differently against the mutant EGFR cells.

The scientists also looked at cases of four NSCLC patients with EGFR mutations who had been treated with the two drugs. The scientists' predictions were confirmed: all patients had some tumor shrinkage when they received Iressa, but none of the cancers responded to Erbitux.

Janne says that the experiment told the scientists something new about the biology of the EGFR mutation in NSCLC. "The lesson is, to inhibit the mutant receptor, you need to inhibit the domain of the EGFR molecule that lies within the cell, as opposed to the extracellular domain," Jänne says.


'"/>

Source:Dana-Farber Cancer Institute


Page: 1 2

Related biology news :

1. Mouse with designer liver has enhanced glucose tolerance, insulin response
2. Molecular machine may lead to new drugs to combat human diseases
3. Researchers identify target for cancer drugs
4. MetaChip provides quick, efficient toxicity screening of potential drugs
5. Newly discovered pathway might help in design of cancer drugs
6. UNC launches study of liver injury caused by drugs
7. Findings have implications for tracking disease, drugs at the molecular level
8. Future diabetes drugs may target new protein interaction
9. UCLA study assesses cost-effectiveness of Hepatitis B drugs
10. Sponges as drugs
11. Newest HIV drugs should be used with FUZEON(R)
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Two designer drugs hit same lung cancer target but only one effective

(Date:4/15/2014)... ITHACA, N.Y. If an insect drew a line ... would be a tangled mess. But there,s method to ... of mechanical engineering and physics, who tries to find ... Photo: https://cornell.box.com/tbeetle , It turns out the ... an optimal reorientation dance as it chases its prey ...
(Date:4/15/2014)... the loveliest in the world, but they also contain ... have become enriched in cadmium. Grasses take up this ... cattle and sheep that graze them. The problem is ... worldwide. , The concern is that if cadmium concentrations ... human health and New Zealand,s agricultural economy could be ...
(Date:4/15/2014)... world for which no pharmaceutical treatment exists. These include, ... in the tropics, as well as a type of ... easily spread by the hands and can be dangerous ... at Aalto University and the University of Eastern Finland ... spread of one type of virus into cells with ...
Breaking Biology News(10 mins):Photo: Tiger beetle's chase highlights mechanical law 2Nanocrystalline cellulose modified into an efficient viral inhibitor 2
... 2008 -- In a move that promises to change the ... unveiled a set of techniques for cleanly converting problematic biofuels ... research is available online in the journal Metabolic Engineering ... describe a new fermentation process that allows E. coli ...
... Southern Research Station (SRS) today announced that an SRS ... responsible for killing redbay and other trees in the ... Lead author and Iowa State University ... Stephen Fraedrich, and Azerbaijan National Academy of Sciences Researcher ...
... IMMEDIATE RELEASE The tummy,s taste for red wine ... Chemistry What happens when red wine meets red ... Israel are reporting, wine,s bounty of healthful chemical compounds may ... in the meat. The study, which reinforces the benefits of ...
Cached Biology News:Research yields pricey chemicals from biodiesel waste 2Research yields pricey chemicals from biodiesel waste 3Tree-killing fungus officially named by scientists 2American Chemical Society's Weekly PressPac -- June 25, 2008 2American Chemical Society's Weekly PressPac -- June 25, 2008 3American Chemical Society's Weekly PressPac -- June 25, 2008 4American Chemical Society's Weekly PressPac -- June 25, 2008 5American Chemical Society's Weekly PressPac -- June 25, 2008 6American Chemical Society's Weekly PressPac -- June 25, 2008 7American Chemical Society's Weekly PressPac -- June 25, 2008 8American Chemical Society's Weekly PressPac -- June 25, 2008 9
(Date:1/15/2014)... the device," Nobel laureate Herbert Kroemer famously ... be found at the junctures where layers ... world of nanotechnology, the interfaces between layers ... with applications in such high-tech favorites as ... the vast potential of these metal oxide ...
(Date:1/15/2014)... NIAGARA FALLS, N.Y., Jan. 15, 2014 /PRNewswire/ ... announce that it has been selected by Buffalo ... component supplier in support of its SBIR Phase ... B3 has developed the only comprehensive air purification ... VOCs and other chemical pollutants, allergens and organic ...
(Date:1/15/2014)... SAN JOSE, California , January 15, 2014 /PRNewswire/ ... developing antibody-drug conjugates for cancer, today announced the appointment ... of Directors. Dr Reynolds has over 20 years, development ... Chief Medical Officer at Seattle Genetics. "I ... for Oxford BioTherapeutics, as the company completes its transition ...
(Date:1/15/2014)... 15, 2014 A study has ... races on the Formula 1 track could help to ... between McLaren Applied Technologies (MAT), Stowhealth (a GP surgery ... is being funded by healthcare provider Simplyhealth. ... collect data about the on-track performance of Vodafone McLaren ...
Breaking Biology Technology:A deeper look at interfaces 2Niagara Thermal Products LLC Selected as Critical Supplier for Buffalo BioBlower Air Purification Systems 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 4
... HOUSTON, Jan. 7 Cyberonics, Inc. (Nasdaq: CYBX ... the U.S. Food and Drug Administration ("FDA") to amend the ... treated with VNS TherapyTM.Based on a reassessment of the study ... to the data analysis originally specified in the study protocol, ...
... ALTO, Calif., Jan. 7 Intradigm Corporation, a ... today,announced that the company has closed the final ... led the $2.9 million tranche, with,existing investor, Lilly ... brings the total Series B financing to $21.4 ...
... TAMPA BAY, Fla., Jan. 7 News briefs concerning economic,and ... Bay Partnership: , Draper Labs Acquires ... The Charles Stark Draper Laboratory bought a 41,000-square-foot building,in St. ... Renovations to the building, 10050 16th St. N., should ...
Cached Biology Technology:Cyberonics Provides Business Update on Depression Clinical Trial 2Cyberonics Provides Business Update on Depression Clinical Trial 3Intradigm Closes Final Tranche of $21.4 Million Series B Financing 2Intradigm Closes Final Tranche of $21.4 Million Series B Financing 3Highlights of Economic and Business Growth in the Tampa Bay Region (News Briefs) 2Highlights of Economic and Business Growth in the Tampa Bay Region (News Briefs) 3Highlights of Economic and Business Growth in the Tampa Bay Region (News Briefs) 4