( LA's previous research shows that telom...)Two chemicals boost immune cells' ability to fight HIV without gene therapy
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Two chemicals boost immune cells' ability to fight HIV without gene therapy
LA's previous research shows that telomerase rejuvenates the telomeres and allows the immune cells to remain youthful and active as they replicate under HIV's attack. Drugs that activate telomerase also offer therapeutic potential for a wide spectrum of degenerative diseases and chronic conditions in which cellular aging plays a role.
"I'm really excited by our findings. This progress moves us one step closer to drugs that work by switching telomerase on permanently and keeping the immune cells young and strong in their fight against infection," said Effros. "These therapies are also easier to develop than gene-therapy drugs."
The research was supported by a grant from the National Institute of Allergy and Infectious Diseases and a University of California Discovery Grant. Geron provided additional funding and the chemical compounds for use in the laboratory.
Effros' team included doctoral student Steven Fauce; Beth Jamieson, Ph.D., assistant professor hematology-oncology; and Otto Yang, Ph.D., associate professor of infectious diseases, all from UCLA.
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Source:UCLA
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