Navigation Links
Two central mysteries in genome inheritance solved at UCSD

pending on the species, requires specialized protein polymers called microtubules.

"After the genome is replicated, microtubule polymers build a spindle-shaped structure whose two ends collect precisely half of the duplicated genome before the cell is pinched in the middle to form two cells," said Desai. Chromosomes connect to the spindle microtubule polymers during this time, and interfering with this connection ?using drugs that bind to microtubule polymers ?is a common chemotherapy strategy used to target and curtail rapidly dividing cancer cells. While scientists have known that breakdown of this connection could stop the proliferation of cancerous cells, they didn't know how the connection itself was established.

Using a biochemical approach, Desai and postdoctoral fellow Iain Cheeseman, Ph.D., have solved this mystery. In the December 1 paper, they identified a protein group that forms the chromosome-spindle connection and is present in even the simplest single-celled organisms, indicating that its role in genome distribution is ancient and widely conserved. Identification of this protein group provides scientists with new drug targets in cancer cells.

"Right now, drugs used in chemotherapy affect microtubules in all the body's cells, resulting in adverse side effects, like nerve pain and loss of sensation ," said Desai. "If we could specifically target dividing cells, we should improve on current chemotherapy to treat the cancer with fewer side effects."

The second paper from Desai's research group, to be published in the December 15 issue of Cell, identifies a different type of connection between chromosomes and microtubule polymers, which operates to discriminate between correct and incorrect chromosome-spindle attachments.

Each replicated chromosome is comprised of a pair of identical sister chromatids, generated by the copying of the parental DNA strand. These pairs are held together during the early
'"/>

Source:University of California - San Diego


Page: 1 2 3

Related biology news :

1. Alcohols effects on gene expression in the central nervous system
2. Poaching, logging, and outbreaks of Ebola threaten central African gorillas and chimpanzees
3. Researchers identify molecular anchor that allows bacterial invasion of central nervous system
4. Small molecule interactions were central to the origin of life
5. Mayo Clinic study suggests that a central nervous system viral infection can lead to memory deficits
6. ORNL, UC Berkeley unravel real-world clues to Earths mysteries
7. Tufts researchers shine light on firefly mysteries
8. Unraveling the mysteries of poison
9. How satellite tracking revealed the migratory mysteries of endangered Atlantic loggerhead turtles
10. Theory of oscillations may explain biological mysteries
11. Man and mouse share genome structures
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Two central mysteries genome inheritance solved UCSD

(Date:6/24/2015)... NEW YORK , June 24, 2015 ... Systems market, over the next six years. It contains ... affect the industry, along with their impact from the ... It also discusses the industry, market, and technology ... expected that the need of concerned authorities to efficiently ...
(Date:6/23/2015)...   MedNet Solutions , an innovative SaaS-based ... of clinical research, is pleased to announce that ... company,s intuitive, flexible and affordable cloud-based eClinical technology ... Award by the American Business Awards (SM) ... The American Business Awards are considered the nation,s ...
(Date:6/18/2015)... , June 18, 2015 This report analyzes ... by the following Product Segments, which includes Immunoassay Analyzers ... Immunoassay Systems, Radio Immunoassay Systems, and Nephelometric Immunoassay Systems. ... Canada , Japan ... , Latin America , and ...
Breaking Biology News(10 mins):Automatic Identification System Market by Class, by Platform, by Application and by Geography - Global Forecasts & Analysis to 2014 - 2020 2MedNet Solutions' iMedNet eClinical Wins Silver Stevie Award 2Global Immunoassay Systems Market 2Global Immunoassay Systems Market 3Global Immunoassay Systems Market 4Global Immunoassay Systems Market 5Global Immunoassay Systems Market 6Global Immunoassay Systems Market 7Global Immunoassay Systems Market 8Global Immunoassay Systems Market 9Global Immunoassay Systems Market 10Global Immunoassay Systems Market 11Global Immunoassay Systems Market 12Global Immunoassay Systems Market 13Global Immunoassay Systems Market 14Global Immunoassay Systems Market 15Global Immunoassay Systems Market 16Global Immunoassay Systems Market 17Global Immunoassay Systems Market 18Global Immunoassay Systems Market 19Global Immunoassay Systems Market 20Global Immunoassay Systems Market 21Global Immunoassay Systems Market 22Global Immunoassay Systems Market 23Global Immunoassay Systems Market 24Global Immunoassay Systems Market 25Global Immunoassay Systems Market 26Global Immunoassay Systems Market 27Global Immunoassay Systems Market 28Global Immunoassay Systems Market 29
... who dealt with the strain of a hurricane or major ... were at elevated risk for abnormal health conditions at birth, ... that offers new insights into the effects of stress on ... meteorological information to identify children born in the state between ...
... the Hollings Marine Laboratory (HML) and four partner organizations ... perfluoroalkyl compounds (PFCs) in five different endangered species of ... been conducted on turtles, the levels of the compounds ... to cause adverse health effects in other animals. ...
... to the U.S. for sale through plant nurseries, are ... legislation restricts the introduction of certain species, the procedures ... list are haphazard and out of date. ... analysis, researchers at the University of Georgia Odum School ...
Cached Biology News:Study offers new insights into the effects of stress on pregnancy 2Study offers new insights into the effects of stress on pregnancy 3Study offers new insights into the effects of stress on pregnancy 4Pollutants could pose health risks for 5 sea turtle species 2Pollutants could pose health risks for 5 sea turtle species 3Screening horticultural imports: New models assess plant risk through better analysis 2Screening horticultural imports: New models assess plant risk through better analysis 3
(Date:6/26/2015)... ... 2015 , ... Claremont BioSolutions, LLC, a pioneer of rapid ... a sample prep module intended to enable real-time quantitative gene expression analysis on ... Project. , On June 28, 2015, SpaceX CRS-7 will launch from Cape Canaveral ...
(Date:6/26/2015)... ... June 26, 2015 , ... DNA Genotek, ... of OraSure Technologies, Inc. (Nasdaq: OSUR) today announced that it has awarded grants ... Gut Microbiome Grant Program. The company has awarded its OMNIgene®•GUT fecal/stool ...
(Date:6/26/2015)... , ... June 26, 2015 , ... ReliantHeart, Inc. ... indicates that from the first implant of the HeartAssist5® LVAD (HA5) to the 68th ... HA5. , Thrombus that originates in an LVAD is referred to as de ...
(Date:6/25/2015)... , June 25, 2015 ... ) has announced the addition of ... the Global Cancer Diagnostics Industry: Oncogenes, ... Immunohistochemical Stains--Hospitals, Commercial Labs, POC Locations" ...      (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , ...
Breaking Biology Technology:Claremont BioSolutions’ SimplePrep™ Products Deployed in NASA Wetlab-2 Project Slated for June 28th Flight to International Space Station aboard SpaceX CRS-7 2Claremont BioSolutions’ SimplePrep™ Products Deployed in NASA Wetlab-2 Project Slated for June 28th Flight to International Space Station aboard SpaceX CRS-7 3DNA Genotek Inc. Announces Recipients of Gut Microbiome Grant Program 2DNA Genotek Inc. Announces Recipients of Gut Microbiome Grant Program 3HeartAssist5® Remote Monitoring has alerted no patterns of de novo thrombus in 68 consecutive implants 2HeartAssist5® Remote Monitoring has alerted no patterns of de novo thrombus in 68 consecutive implants 3Analysis of the Global Cancer Diagnostics Industry 2015-2020: Oncogenes, Biochemical Markers, Lymphokines, GFs, CSFs, Hormones, Immunohistochemical Stains 2Analysis of the Global Cancer Diagnostics Industry 2015-2020: Oncogenes, Biochemical Markers, Lymphokines, GFs, CSFs, Hormones, Immunohistochemical Stains 3
... 6 State, county and local government leaders today ... REGN ) and BioMed Realty Trust, Inc. (NYSE: ... 229,000 square foot corporate headquarters and research facility at ... York. Featured speakers at the ceremony were Leonard S. ...
... Fla., Oct. 6 The ability of a proprietary ... in a double-blind, placebo-controlled study, undertaken on behalf of ... conducted by Dr. Fan-kun Kong, assisted by medical personnel ... place during the spring 2009 flu season and involved ...
... Verenium Corporation (Nasdaq: VRNMD ), a pioneer ... specialty enzymes, today announced that it intends to offer, ... its common stock, and potentially warrants, in an underwritten ... before 9:30 am EDT on Tuesday, October 6, 2009. ...
Cached Biology Technology:Regeneron Pharmaceuticals and BioMed Realty Trust Host Ribbon-Cutting Ceremony at the Landmark at Eastview 2Regeneron Pharmaceuticals and BioMed Realty Trust Host Ribbon-Cutting Ceremony at the Landmark at Eastview 3Regeneron Pharmaceuticals and BioMed Realty Trust Host Ribbon-Cutting Ceremony at the Landmark at Eastview 4Regeneron Pharmaceuticals and BioMed Realty Trust Host Ribbon-Cutting Ceremony at the Landmark at Eastview 5HerbalScience Releases Results of Pilot Clinical Study on Efficacy of Its Proprietary Elderberry Extract in Addressing Flu-Like Symptoms 2HerbalScience Releases Results of Pilot Clinical Study on Efficacy of Its Proprietary Elderberry Extract in Addressing Flu-Like Symptoms 3HerbalScience Releases Results of Pilot Clinical Study on Efficacy of Its Proprietary Elderberry Extract in Addressing Flu-Like Symptoms 4Verenium Announces Proposed Public Offering of Common Stock 2Verenium Announces Proposed Public Offering of Common Stock 3