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Two are better than one

and, when chemotherapy is used in combination with the immunotherapy, it dies.

According to Sela, the study sheds light on the synergy at work in the antibody-receptor therapy system. The results demonstrate that with the right combination of antibodies, receptor degradation is accelerated: it's more than three times as effective as a single antibody in inhibiting HER2 signaling.

"Understanding how HER receptor degradation works could enhance weak therapeutic efficacy, as well as provide ways to sensitize patients to overcome inherent or acquired resistance to cancer treatment," says Yarden.

Prof. Yosef Yarden's research is supported by the Y. Leon Benoziyo Institute for Molecular Medicine; the Dolfi and Lola Ebner Center for Biomedical Research; the J & R Center for Scientific Research; the Aharon Katzir-Katchalsky Center; the M.D. Moross Institute for Cancer Research; the Willner Family Center for Vascular Biology; the Batsheva De Rothschild Foundation; Dr. Marvin Klein, Farmington Hills, MI; Mr. & Mrs. Bram Laub, Belgium; and the Herbert J. Seligmann Charitable Trust. Prof. Yarden is the incumbent of the Harold and Zelda Goldenberg Professorial Chair in Molecular Cell Biology.

Prof. Michael Sela's research is supported by the Y. Leon Benoziyo Institute for Molecular Medicine, and the Dolfi and Lola Ebner Center for Biomedical Research. Prof. Sela is the incumbent of the W. Garfield Weston Professorial Chair of Immunology.


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Source:Weizmann Institute


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