Navigation Links
Twin studies reveal genetic components leading to cardiac and kidney disease

Daniel O’Connor, M.D., Professor of Medicine and Pharmacology at the University of California, San Diego (UCSD) School of Medicine has studied about 265 twin pairs over the past few years, which has led him to some surprising discoveries.

"By studying many traits and genes, we have started to put together unexpected stories," he said.

Studying genetic variations in twins provides scientists with data on traits that are heritable, or passed down through human DNA, versus those determined by the environment, age or how a person cares for his or her health, factors such as medical care or diet and exercise. In a series of studies published in the American Heart Association journals Circulation and Hypertension, O’Connor has identified particular genes that influence human health in unexpected ways.

"Factors linked to cardiac or kidney disease ?such as hypertension, a tendency toward obesity or diabetes, elevated blood glucose and lipids ?were just amorphous risk factors before," said O’Connor. "Now we know that they run in families, not only because of a shared environment, but because they are determined in part by particular genes.

"Behavioral studies with twins have been conducted for decades, but in the post-genomic era, we can now factor in genotypes and determine the effect of specific genes on traits," O’Connor said. By studying both monzygotic (MZ, or genetically identical) and dizygotic (DZ, or fraternal, who share half of their genetic information) twin pairs, researchers can more readily pinpoint specific genes in people who are the same age. A formula measuring the difference in the frequency of traits between the siblings in each MZ and DZ twin pair establishes what is called the index of heritability.

The human genome has three billion base pairs and about 30,000 genes. O’Connor and his research team have looked at about 900 of these 30,000 genes.

"We’re just scratching the surface," he said.
'"/>

Source:University of California - San Diego


Page: 1 2 3

Related biology news :

1. New studies suggest airborne SARS transmission is possible
2. Two studies document rise of superbugs in the environment
3. UI researcher studies deafness in fruit flies, humans
4. Biased reporting found in cancer prognostic studies
5. Fruit fly studies open new window on cancer research
6. Why do aneurysms form? New studies suggest leading role for white blood cells
7. Bare metal stents deliver gene therapy to heart vessels with less inflammation in animal studies
8. Diabetes researchers pioneer islet cell xenotransplantation in primate studies
9. Pair of studies offer new clues to combat antibiotic resistance
10. New RNAi tools enable systematic studies of gene function
11. Ernst Mayrs theory illustrated in genetic epidemiology studies
Post Your Comments:
(Date:12/17/2014)... , Dec. 16, 2014  Automation is fundamentally ... more evident than at international borders. Over the ... scanners have allowed veteran travelers to self process ... Control (APC) Kiosks at an increasing number of ... According to Maxine Most ...
(Date:12/11/2014)... , Dec. 09, 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/twhjll/biometrics_market ) has announced ... the APAC Region 2015-2019"  report to their offering. ... this market is advances in technology. With continuous ... biometric solutions to the latest standard that meets ...
(Date:12/11/2014)...  That blood pressure plays a role in human health ... medical term for high blood pressure – was first described ... cuff that,s used in measuring blood pressure was invented in ... about hypertension, its triggers and its effects. In fact, recent ... the best ways to treat it. For example, ...
Breaking Biology News(10 mins):Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2Research points to need for new approaches to treatment of high blood pressure 2Research points to need for new approaches to treatment of high blood pressure 3Research points to need for new approaches to treatment of high blood pressure 4
... brain cancer can be like looking for a needle in ... be the right one. By comparing human and canine genomes, ... gene commonly believed to be involved in meningiomas-tumors that affect ... account for one out of four adult brain tumors -may ...
... enables individuals to maneuver a powered wheelchair or control ... operated by individuals with high-level spinal cord injuries, according ... "This clinical trial has validated that the Tongue ... with high-level spinal cord injuries to use," said Maysam ...
... University of Alberta professor in the department of chemistry, has ... science of the United Kingdom and the Commonwealth. The ceremony ... Included in the Royal Society,s membership are Isaac Newton, Charles ... laureates among the society,s 1,400 members. Vederas is being ...
Cached Biology News:Dogs, humans, put heads together to find cure for brain cancer 2Dogs, humans, put heads together to find cure for brain cancer 3Clinical trial shows quadriplegics can operate powered wheelchair with tongue drive system 2Clinical trial shows quadriplegics can operate powered wheelchair with tongue drive system 3Clinical trial shows quadriplegics can operate powered wheelchair with tongue drive system 4
(Date:12/22/2014)... Dec. 22, 2014  ( www.competitivehealth.com ) — Competitive ... medical bill review and advocacy service, has signed an ... WellCard Savings discount health services marketplace. 63% ... more than they expected to pay. As part of ... costs, WellCard Savings is pleased to offer medical bill ...
(Date:12/22/2014)... 22, 2014 Fertility Associates of Memphis ... Bank USA , a network of more than 20 ... partnership, patients have fast access to a national pool ... IVF . Fertility Associates of Memphis is the only ... treatment option. , Dr. William Kutteh , director ...
(Date:12/19/2014)... BioPlus Specialty Pharmacy (BioPlus), one ... of Nick Maroulis, Pharm.D. to the newly created position ... In this position, Dr. Maroulis will continue to manage ... of our multi-site pharmacies as the company expands. Dr. ... that time he has served in many different capacities ...
(Date:12/19/2014)... Dec. 19, 2014 Bina Technologies, Inc. (Bina, ... that they have been acquired by Roche (SIX: RO, ... privately held company that provides a big data platform ... (NGS) data for the academic and translational research markets. ... and will continue to focus on development of their ...
Breaking Biology Technology:WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 3BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2Bina Technologies is acquired by Roche. 2Bina Technologies is acquired by Roche. 3
... applying a coating to individual silicon nanowires, researchers at ... and sensitivity. The findings, published in the May ... that the coated wires hold promise for photodetectors and ... a large surface-to-volume ratio, nanowires typically suffer from a ...
... July 6, 2011 The Association for ... "Expanding Career Readiness Through Career and Technical Student ... career and technical student organizations (CTSOs) strengthen their ... as leadership development, academic and career development, professional ...
... July 6, 2011 Reportlinker.com announces that a ... catalogue: Biobanking: Technologies and Global ... REPORT HIGHLIGHTS ... overview of biobanks by types: Population, Disease, and ...
Cached Biology Technology:With a simple coating, nanowires show a dramatic increase in efficiency and sensitivity 2ACTE Releases Paper on How Career, Technical Student Organizations Expand Career Readiness for Students 2ACTE Releases Paper on How Career, Technical Student Organizations Expand Career Readiness for Students 3Biobanking: Technologies and Global Markets 2Biobanking: Technologies and Global Markets 3Biobanking: Technologies and Global Markets 4Biobanking: Technologies and Global Markets 5Biobanking: Technologies and Global Markets 6Biobanking: Technologies and Global Markets 7Biobanking: Technologies and Global Markets 8Biobanking: Technologies and Global Markets 9Biobanking: Technologies and Global Markets 10Biobanking: Technologies and Global Markets 11Biobanking: Technologies and Global Markets 12Biobanking: Technologies and Global Markets 13
... The lyophilization stabilizer is designed ... process and for long-term storage. ... toxic ingredients. It is a ... pH 7.2, and is superior to ...
... coating stabilizer is designed for stabilizing ... and antibodies for immunoassay development. ... during the coating and drying process ... It can also works as a ...
... Clinical is Tecans open platform for clinical ... safety and performance in the clinical diagnostic ... by flexible barcode reading and sample traceability ... the system complies with the IVD-Directive* established ...
... the smallest thermal cyclers on the market, which ... 0.5ml (20 samples) or 0.2ml microtube (25 samples) ... and cooling rate of 3.6C/sec and 2.0C/sec respectively ... Fast track programming with new quick dial facility ...
Biology Products: