Navigation Links
Twin studies reveal genetic components leading to cardiac and kidney disease

Daniel O’Connor, M.D., Professor of Medicine and Pharmacology at the University of California, San Diego (UCSD) School of Medicine has studied about 265 twin pairs over the past few years, which has led him to some surprising discoveries.

"By studying many traits and genes, we have started to put together unexpected stories," he said.

Studying genetic variations in twins provides scientists with data on traits that are heritable, or passed down through human DNA, versus those determined by the environment, age or how a person cares for his or her health, factors such as medical care or diet and exercise. In a series of studies published in the American Heart Association journals Circulation and Hypertension, O’Connor has identified particular genes that influence human health in unexpected ways.

"Factors linked to cardiac or kidney disease ?such as hypertension, a tendency toward obesity or diabetes, elevated blood glucose and lipids ?were just amorphous risk factors before," said O’Connor. "Now we know that they run in families, not only because of a shared environment, but because they are determined in part by particular genes.

"Behavioral studies with twins have been conducted for decades, but in the post-genomic era, we can now factor in genotypes and determine the effect of specific genes on traits," O’Connor said. By studying both monzygotic (MZ, or genetically identical) and dizygotic (DZ, or fraternal, who share half of their genetic information) twin pairs, researchers can more readily pinpoint specific genes in people who are the same age. A formula measuring the difference in the frequency of traits between the siblings in each MZ and DZ twin pair establishes what is called the index of heritability.

The human genome has three billion base pairs and about 30,000 genes. O’Connor and his research team have looked at about 900 of these 30,000 genes.

"We’re just scratching the surface," he said.
'"/>

Source:University of California - San Diego


Page: 1 2 3

Related biology news :

1. New studies suggest airborne SARS transmission is possible
2. Two studies document rise of superbugs in the environment
3. UI researcher studies deafness in fruit flies, humans
4. Biased reporting found in cancer prognostic studies
5. Fruit fly studies open new window on cancer research
6. Why do aneurysms form? New studies suggest leading role for white blood cells
7. Bare metal stents deliver gene therapy to heart vessels with less inflammation in animal studies
8. Diabetes researchers pioneer islet cell xenotransplantation in primate studies
9. Pair of studies offer new clues to combat antibiotic resistance
10. New RNAi tools enable systematic studies of gene function
11. Ernst Mayrs theory illustrated in genetic epidemiology studies
Post Your Comments:
(Date:4/2/2015)... According to preliminary estimates Fingerprint ... higher than 125 MSEK. This exceeds the guidance provided ... revenues for Q1 2015 would be in line with ... 2014. The operating result for the first quarter is ... report will as previously communicated be published on May ...
(Date:3/31/2015)... , March 31, 2015  Elephant Talk Communications Corp. ... global provider of Software Defined Network Architecture (ET Software ... total revenue of approximately $20.4 million for the year ... $19.5 million for the year ended December 31, 2013. ... the Company had completed its multi-year transition away from ...
(Date:3/24/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/hdgz7h/global_iris ) has ... Market 2015-2019" report to their offering. ... grow at a CAGR of 23.5 percent over the ... scenario and the growth prospects of the Global Iris ... market size, the report considers the revenue generated from ...
Breaking Biology News(10 mins):Fingerprint Cards Revises Revenues for Q1 2015 2Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 2Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 3Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 4Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 5Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 6Global Iris Recognition Market 2015-2019 with 3M Cogent, Bioenable Technologies, Cross Match Technology, Iris ID Systems & Safran Dominating 2
... PROVIDENCE, R.I. [Brown University] Global warming may exact ... new research shows that one key constituent of marshes ... zones of salt marshes. Despite the stresses associated with ... Keryn Gedan, a graduate student and salt marsh expert ...
... Federal Bureau of Investigation (FBI) has awarded Lockheed Martin ... contract to continue managing the FBI Criminal Justice Information ... contract covers the conversion of paper fingerprint, palm print ... FBI. , , Records processed through this ...
... Technology, an award-winning biometric technology research and development ... agreement with ACS Technologies, the leading provider of ... and other faith-based organizations. , , Through ... be offering Bio-SnapON(TM), a robust biometric identification system ...
Cached Biology News:Climate change may spell demise of key salt marsh constituent 2Federal Bureau of Investigation Awards Lockheed Martin Biometric Card Scanning Service Contract 2ACS Technologies(TM) Selects M2SYS for Innovative Biometric Software 2
(Date:5/4/2015)... Genedata, a leading provider of advanced ... research, today announced the release of Genedata ... enterprise solution for biologics R&D. This first-in-class workflow ... and development of novel biotherapeutics. Version 5.0 enables ... optimization and developability requirements. Genedata will present highlights ...
(Date:5/4/2015)... May 4, 2015 - New ... med students prepare for the United States Medical Licensing ... of scientific, technical and medical information products and services, ... (Massive Open Online Course) designed to help medical students ... Step 1, the first and most daunting of the ...
(Date:5/4/2015)... Marianjoy Rehabilitation Hospital has ... hand impairments by acquiring the Armeo®Spring arm and ... site. , Secured through grant support of a ... option for patients with upper extremity weakness or ... of just four Illinois providers offering treatment with ...
(Date:5/1/2015)... Pfenex Inc. (NYSE MKT: PFNX), a ... biosimilar therapeutics including high value and difficult to ... 2015 financial results will be released on Thursday, ... 8:30 am Eastern Time, Pfenex management will host ... and provide a business update. A press release outlining ...
Breaking Biology Technology:Genedata Biologics 5.0 – Antibody Engineering and Developability Assessment Advances 2Genedata Biologics 5.0 – Antibody Engineering and Developability Assessment Advances 3Genedata Biologics 5.0 – Antibody Engineering and Developability Assessment Advances 4Elsevier's Free MOOC Prepares Med Students for Licensing Exam 2Elsevier's Free MOOC Prepares Med Students for Licensing Exam 3Marianjoy Acquires Armeo®Spring Arm and Hand Rehabilitation Exoskeleton at Oakbrook Terrace Facility 2Pfenex To Report First Quarter 2015 Results and Provide Business Update on Thursday, May 14, 2015 2
... , May 4 Microfluidics International Corporation (OTC Bulletin Board: MFLU) announced ... 11, 2010 , at 8:30am ET . , ... (Logo:   http://www.newscom.com/cgi-bin/prnh/20090811/NE59652LOGO ) , , ... Ferrara , President and Chief Executive Officer, and Peter F. Byczko , Vice ...
... PharmAthene, Inc. (NYSE Amex: PIP ), a biodefense company developing ... Company,s Interim CEO, Eric I. Richman , will be participating ... government, academia and industry in the development of medical countermeasures vital ... , , ...
... like a piece of gel that slips into the sole ... can make computers and the Internet hundreds of times faster ... only five or ten years in the future, currently being ... of Electrical Engineering. Dr. Scheuer has developed a ...
Cached Biology Technology:Microfluidics International Corporation to Report First Quarter 2010 Financial Results on May 11, 2010 2Microfluidics International Corporation to Report First Quarter 2010 Financial Results on May 11, 2010 3PharmAthene CEO To Participate on Biosecurity Panel at the 2010 BIO International Conference 2An optical traffic cop for rapid communication 2
... (RNase III) from E. coli is an ... to dsRNA fragments that have 2-base, 3'-overhangs. ... dsRNA fragments of 12-15 bp. RNase ... canonical ribonucleotides as well as DuraScript™ RNA, ...
Rabbit polyclonal to Peptide E ( Abpromise for all tested applications)....
Mouse monoclonal [6911] to E. coli K99 pilus ( Abpromise for all tested applications)....
...
Biology Products: