Navigation Links
Twin molecular scissors link creation of microRNAs with gene-silencing

er RNA to be inactivated. Using complementarity to match the guide miRNA to a particular length of its target messenger RNA, Dicer and TRBP then hand over the messenger RNA for cutting by Argonaute 2. Still holding the guide miRNA, RISC then scouts for additional copies of its target messenger RNA to cut. The cutting destroys the messenger RNA, effectively silencing the gene from which it was transcribed.

"The two enzymes in the complex are like two scissors working together in a concerted fashion, connected and coordinated by the third member of the complex," Shiekhattar explains.

Another scientific question surrounding RISC was also resolved by the current study. Some investigators had theorized that the activity of RISC required ATP for energy. ATP, or adenosine triphosphate, is a molecule used to store and release energy for tasks throughout the body.

"The work of RISC is being accomplished with no energy requirement whatsoever," Shiekhattar says. "All of the activity ?the separation of the strands, the multiple cutting steps, everything ?is being done in the absence of any energy use."

Instead, he says, the different molecules involved have stronger and weaker affinities for each other that govern their stepwise associations and disassociations as the process unfolds.


'"/>

Source:The Wistar Institute


Page: 1 2

Related biology news :

1. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
2. Source of molecular triggers in cutaneous T cell lymphoma identified
3. Plants, animals share molecular growth mechanisms
4. NYU researchers simulate molecular biological clock
5. Scientists reveal molecular secrets of the malaria parasite
6. Scientists identify molecular events that drive cell senescence
7. Researchers discover molecular mechanism that desensitizes us to cold
8. Findings have implications for tracking disease, drugs at the molecular level
9. Successful Test Of Single Molecule Switch Opens The Door To Biomolecular Electronics
10. At the molecular level, the predator is the prey
11. By creating molecular bridge, scientists change function of a protein
Post Your Comments:
(Date:1/22/2015)... , Europe,s most prestigious ... Office to present a video retrospective of the most exciting and ... Christofer Toumazou and Sophie Wilson   A ... Award   Starting on 22 January 2015 on   http://www.epo.org/european-inventor ...
(Date:12/22/2014)... Inc. (NASDAQ: NXTD and NXTDW) ("NXT-ID" or ... mobile commerce market, announces it has retained famous pickpocket, entertainer ... International CES debut of the Wocket™ biometric smart wallet.  ... NXT-ID booth January 6th and 7 th , 2015, demonstrating ...
(Date:12/19/2014)... VIEW, Calif. , Dec. 18, 2014  23andMe, Inc., the ... study that pinpoints fine-scale differences in genetic ancestry of individuals ... Since immigrants first arrived more than four hundred years ... as a meeting place for peoples from different continents. This ...
Breaking Biology News(10 mins):Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 2Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 3NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 3NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 423andMe Study Sketches Genetic Portrait of the United States 223andMe Study Sketches Genetic Portrait of the United States 323andMe Study Sketches Genetic Portrait of the United States 4
... MANHATTAN, KAN. -- A Kansas State University researcher,s plant ... Mark Ungerer, associate professor of biology, has two major ... state flower of Kansas. "What we do in ... genetics," Ungerer said. "We study naturally occurring species and ...
... , Concerns about the worldwide energy supply and national, environmental ... energy sources. A new University of Illinois study shows ... a strong contender in the race to find the next ... M. x giganteus is a bioenergy crop ...
... beetle dance provides crucial orientation cues: Beetles climb on top of ... The dung beetle dance, performed as the beetle moves away from ... to maintain the desired straight-line departure from the pile, according to ... journal PLoS ONE . The purpose of this ...
Cached Biology News:The power of flowers: Research sprouts a closer look at sunflower genetics 2The power of flowers: Research sprouts a closer look at sunflower genetics 3Findings prove Miscanthus x giganteus has great potential as an alternative energy source 2
(Date:12/24/2014)... Dec. 24, 2014  Vermillion, Inc. (Nasdaq:   VRML), ... announced today that the Company closed its previously ... Management, Jack W. Schuler , Birchview Fund ... $10.5 million, before offering expenses.  The proceeds will ...
(Date:12/24/2014)... GMO corn cases filed across the United States, ... of being consolidated in a Kansas federal court for pretrial ... 162 Corn Litigation, MDL No. 2591 in the U.S. District ... Syngenta GMO corn multidistrict litigation (MDL) has been handed over ...
(Date:12/24/2014)... Bethesda, MD (PRWEB) December 23, 2014 ... law H.R. 83, the Omnibus and Continuing Resolution Appropriations ... hydrocephalus a condition eligible to receive funding through the ... Department of Defense (DoD). The Hydrocephalus Association (HA), working ...
(Date:12/24/2014)... (PRWEB) December 23, 2014 Nashville Fertility Center ... treasurer for the American Society for Reproductive Medicine (ASRM), a ... reproductive medicine. In his new role as treasurer, Dr. ... will have a voice in furthering the mission of ASRM. ...
Breaking Biology Technology:Vermillion Announces Closing of Equity Financing 2Vermillion Announces Closing of Equity Financing 3Carey Danis & Lowe Reports on Syngenta GMO Corn Transfer Order 2Rare Brain Condition Now Eligible for Department of Defense Research Dollars 2Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 2Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 3
... MADISON - Tired of high gas costs and poor ... group of engineering students at the University of Wisconsin-Madison ... the cleanest and most fuel-efficient SUVs in North America. ... could one day be incorporated into mass-production hybrid SUVs. ...
... Doyle began turning up the heat on Republicans on ... had already turned the tables on him regarding problematic state ... subject of a state audit, recently were placed at the ... Kanavas , R-Brookfield, who has worked with the Governor on ...
... you judged Milwaukee by the economic indicators alone, you ... the dusty, bypassed town in the hit animated movie ... Hollywood ending, maybe theres a more prosperous, real-life road ... so, because without a healthy Milwaukee, most of Wisconsin ...
Cached Biology Technology:UW-Madison hybrid-vehicle team places second nationally 2GOP lawmaker faults Doyle for IT problems 2GOP lawmaker faults Doyle for IT problems 3It's an economic fact: As Milwaukee goes, so goes Wisconsin 2It's an economic fact: As Milwaukee goes, so goes Wisconsin 3
KV beta.1 (Q-13)...
Preadipocyte factor-1 [Pref-1, DLK-1], C-terminal...
... PGE2-d4 contains 4 deuterium atoms at ... It is intended for use as an ... E2 (PGE2) by GC- or LC-mass spectrometry. ... products of arachidonic acid and one of ...
Deletions, insertions or substitutions. Mutations in plasmids of size up to 15 kb. Single or multiple mutations...
Biology Products: