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Turning viruses into allies against cancer

, scientists observed significant prolongation of life; complete regression was achieved in up to one-third of the treated mice.

During the second phase of their study, the scientists attached the iodine "symporter" protein to the MV-Edm and injected the newly engineered virus intravenously into the mice carrying the human liver cancer cells.

"Intravenous treatment with this combination followed by injection of radioactive iodine into the mice bearing the human hepatocellular cancer cells resulted in high uptake of the radioactive iodine at the tumor site," said Blechacz. "This provides the possibility of enhancing the therapeutic effect by co-treatment with therapeutic radioactive iodine."

Future studies should help scientists evaluate the efficacy and optimal delivery system of their radio-virotherapy vector.

"We expect this work will take another two years before this technology will be available for testing in patient studies," said Blechacz.


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Source:American Association for Cancer Research


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