Navigation Links
Turning viruses into allies against cancer

the Mayo Clinic in Rochester, Minn., reported that the engineered virus seeks out and destroys liver cancer cells, leaving surrounding healthy tissue in tact.

The iodine "transport" protein attached to the virus acts as a kind of homing beacon for radioactive iodine, providing a second line of attack against the cancer cells, technically known as radio-virotherapy.

"These results clearly demonstrate the high potential of this modified virus to serve as a novel vector for cancer gene therapy of hepatocellular carcinoma," said Boris Blechacz, M.D., a research fellow in the Molecular Medicine Program at the Mayo Clinic and the study's lead investigator.

Liver cancer is one of the leading causes of cancer death worldwide, causing nearly a million deaths per year. Despite a variety of differing treatment approaches, its prognosis remains poor with a median survival of about 10 months following diagnosis. For this reason, scientists are anxious to find novel methods that could improve short- and long-term survival from this disease.

"The attenuated vaccine strain of measles virus is an oncolytic virus which has shown anti-tumor activity and tumor-selectivity in a variety of different tumor models," said Blechacz. "But its potential in primary liver tumors has never been evaluated."

In the first part of their study, the scientists studied the impact of their modified measles virus (MV-Edm) in liver cancer cell lines from human patients. Analysis of liver cancer cells removed from patients shows that these cells contain large amounts of the natural receptor for the measles virus, CD46. Overexpression of this receptor thus makes liver cancer cells ideal targets for the measles virus. The results confirmed widespread infectivity, toxicity and destruction among these cells, probably through apoptosis or programmed cell death.

When the modified virus was injected directly into human liver cancer cells grafted onto laboratory mice
'"/>

Source:American Association for Cancer Research


Page: 1 2 3 4

Related biology news :

1. Turning a cellular sentinel into a cancer killer
2. Turning green gunk to gold, anti-cancer gold
3. Studies reveal methods viruses use to sidestep immune system
4. Molecular fossils uncover link between viruses and the immune system
5. Scientists reveal the shape of a protein that helps retroviruses break into cells
6. Bee mites suppress bee immunity, open door for viruses and bacteria
7. Internet viruses help ecologists control invasive species
8. Insects, viruses could hold key for better human teamwork in disasters
9. Two new retroviruses—transmitted from animals—identified
10. Scientists find viruses cant stick to sea bugs in the dark
11. Scientists show that tick-borne flaviviruses use a novel mechanism to evade host defenses
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Turning viruses into allies against cancer

(Date:6/24/2015)... SAN JOSE, Calif. , June 24, 2015 ... leading developer of human interface solutions, today announced ... fingerprint sensor to provide secure authentication for its ... Having recently reached more than 200 million shipments ... shipment with Sharp reinforces Synaptics, strength, scalability and ...
(Date:6/24/2015)... 24, 2015 Biometry authentication provider KeyLemon ... password solution one face in. ... one face in, entering the expanding biometric authentication ... multifactor-authentication biometric answer to the password problem. With ... partnership with KeyLemon, one face in allows users ...
(Date:6/23/2015)... Research and Markets( ... "Body-Worn Temperature Sensors Market - Global Industry ... - 2020" report to their offering. ... global body-worn temperature sensors market. The global body-worn ... basis of types, care setting, patient demographic, applications ...
Breaking Biology News(10 mins):Synaptics Brings Natural ID Technology to Sharp's Newest Flagship Smartphone 2KeyLemon Announces Partnership With Biometric Password Solution onefacein 2Body-Worn Temperature Sensors Market - Global Industry Analysis 2
... Ohio State University will battle for the BCS National ... but if the game was held in the Louisiana ... Louisianas wetlands are being lost at the rate of ... against this rapid destruction, the two universities joined forces ...
... Spanish . , A study carried out by ... of the University of Granada , in collaboration ... Andaluza de Salud Pblica), found that 100% of Spaniards analyzed ... substances internationally classified as potentially harmful to ones health, in ...
... The number of overweight and obese Americans continues to grow ... to 20 percent are obese. While the number of overweight/obese ... of overweight infants -- individuals under 11 months old -- ... women who are overweight/obese are more likely to give birth ...
Cached Biology News:LSU and Ohio State battle on football field, collaborate in research field 2100 percent of people carry at least 1 type of pesticide 2100 percent of people carry at least 1 type of pesticide 3Mom's obesity during conception phase may set the stage for offspring's obesity risk 2Mom's obesity during conception phase may set the stage for offspring's obesity risk 3Mom's obesity during conception phase may set the stage for offspring's obesity risk 4
(Date:7/1/2015)... ALTO, Calif. , July 1, 2015 /PRNewswire/ ... focused on the development of groundbreaking drugs to ... (ALS), announced today that Robert G. Miller ... Center at Sutter Health,s California Pacific Medical Center ... The ALS Association for $1.5 million to help ...
(Date:7/1/2015)... ... ... Apex Therapeutics announced today that company CEO, David Broecker provided a company ... presentation took place on Tuesday, June 16 and provided an update on the achievement ... treatment of pancreatic cancer. A copy of the company overview can be found ...
(Date:6/30/2015)... /PRNewswire/ - Resverlogix Corp. ("Resverlogix") (TSX:RVX) announced today ... have approved the resolutions relating to: (i) a ... units at a price of $2.67 per unit ... of one common share and 0.075358 common share ... million; and (ii) the amendment to Resverlogix,s articles ...
(Date:6/30/2015)... ... June 30, 2015 , ... uBiome and OpenBiome Partner ... mechanics of fecal microbiota transplantation in C. difficile patients. , SAN FRANCISCO, uBiome ... undergoing fecal microbiota transplantation (FMT) as a treatment for Clostridium difficile infections (C. ...
Breaking Biology Technology:Investigator to Receive $1.5 Million Grant from the ALS Association to Help Fund Confirmatory Phase 2 Study of Neuraltus Pharmaceuticals' NP001 2Investigator to Receive $1.5 Million Grant from the ALS Association to Help Fund Confirmatory Phase 2 Study of Neuraltus Pharmaceuticals' NP001 3Investigator to Receive $1.5 Million Grant from the ALS Association to Help Fund Confirmatory Phase 2 Study of Neuraltus Pharmaceuticals' NP001 4Apex Therapeutics Presented Company Overview at This Year’s BIO International Convention in Philadelphia, PA 2Resverlogix Corp. Shareholders Approve Matters Relating to Licensing and Equity Arrangement 2Resverlogix Corp. Shareholders Approve Matters Relating to Licensing and Equity Arrangement 3uBiome and OpenBiome Partner for Microbiome Study in FMT Patients 2uBiome and OpenBiome Partner for Microbiome Study in FMT Patients 3
... quarter ConjuGon CEO to speak on both coasts ... Wisconsin DOA buys Seritis software for data management ... GE Healthcare profits up 31 percent for quarter ... same quarter last year, the company has reported. The firms revenues ...
... Middleton, Wis. Lucigen , a ... has landed federal support to commercialize enzymes from rare microbes ... Park. , ,The U.S. Department of Energy's Joint Genome ... that will help Lucigen sort through the microbes and find ...
... Institute predicts moderate Wisconsin biopharmaceutical growth ... Third Wave appoints regulatory director , ... ,Wisconsin is home to significant biopharmaceutical innovation but ... a recent report prepared by the Milken ...
Cached Biology Technology:Tech Digest: whats moving in the Midwest 2Tech Digest: whats moving in the Midwest 3Tech Digest: whats moving in the Midwest 2
... glutathione-S-transferase (GST) is commonly used as a ... coli (1). The GSTTag sequence has been ... some cases the solubility of its fusion ... folded form, GSTTag fusion proteins can be ...
... Kit with Medium High quality ready-to-use cryopreserved ... base medium for growth and lineage commitment. ... generated from E18 fetal rat brain in ... mixture of in vitro stem/progenitor cells, neurons, ...
... ELx50 is a fast and versatile automated ... our patented Dual-ActionTM 16-channel manifold. This breakthrough ... dispense and aspiration manifolds for overfill washing ... 384-well formats. The problem of fitting dispense ...
... HybArray 12™ is an automated hybridization system ... system automates both the hybridization and post ... slides. A single instrument can process up ... pairs and has multi-protocol software, enabling the ...
Biology Products: