Navigation Links
Turning a cellular sentinel into a cancer killer

Howard Hughes Medical Institute researchers have developed two strategies to reactivate the p53 gene in mice, causing blood, bone and liver tumors to self destruct. The p53 protein is called the "guardian of the genome" because it triggers the suicide of cells with damaged DNA.

Inactivation of p53 can set the stage for the development of different types of cancer. The researchers' findings show for the first time that inactivating the p53 gene is necessary for maintaining tumors. While the researchers caution that cancers can mutate to circumvent p53 reactivation, they believe their findings offer ideas for new approaches to cancer therapy.

The research was carried out independently by two Howard Hughes Medical Institute (HHMI) research teams led by Tyler Jacks at the Massachusetts Institute of Technology and Scott Lowe at Cold Spring Harbor Laboratory. Both papers were published online January 24, 2007, in advance online publication articles in the journal Nature. Although researchers have long known that p53 inactivation plays a central role in the development of cancer, little was known about whether p53 inactivation played a role in maintaining cancers. And researchers were not sure whether switching p53 back on in tumor cells would have any therapeutic effect.

"It had been demonstrated that overexpressing p53 at very high levels could arrest or kill tumors, said Lowe. "But at such high levels, p53 might not be working through a physiological mechanism. So, it was an open question whether restoring the p53 pathway would have any anti-tumor effect." For one thing, the high mutation rate in cancers might enable a cancer to switch the p53 pathway back off, or to circumvent the pathway in some other fashion. For those reasons, researchers were not sure whether the pathway would be a useful therapeutic target.

To reactivate p53, Lowe and his colleagues used a genetic technique they had developed to induce an aggressive form of liver
'"/>

Source:Howard Hughes Medical Institute


Page: 1 2 3 4

Related biology news :

1. Turning viruses into allies against cancer
2. Turning green gunk to gold, anti-cancer gold
3. Scientists discover the cellular roots of graying hair
4. Vital step in cellular migration described by UCSD medical researchers
5. MSI releases moleculizer - a new approach to simulation of intracellular biochemical networks
6. New study to explore cellular circuitry
7. Study provides insight into cellular defenses against genetic mutation
8. Carnegie Mellon develops non-invasive technique to detect transplant rejection at cellular level
9. Liver cancer linked to cellular repair pathway
10. New cellular flaw found in some virulent breast cancers
11. Insects that produce males from unfertilized eggs reveal a surprising cellular feat
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Turning cellular sentinel into cancer killer

(Date:7/11/2014)... July 11, 2014 Research and Markets ... Biometrics Technology Market - Industry Analysis Size Share Growth ... offering. http://photos.prnewswire.com/prnh/20130307/600769 ... has created a need for high level security in ... personnel authentication such as username and passwords, tokens etc. ...
(Date:7/11/2014)... Brazil- In the brains of all vertebrates, information ... an electric or chemical signal to be passed ... which are the most abundant type of synapse, ... is crucial for learning, memory, perception and cognition, ... critical for brain function. For instance, every ...
(Date:7/10/2014)... Colo. , June 27, 2014  The ... the National Institute of Standards and Technology (NIST) ... of its academic research and forensic science expert ... The Board is an element of the NIST,s ... members are among the first appointments made to ...
Breaking Biology News(10 mins):International Biometrics Technology Market - Industry Analysis Size Share Growth Trends and Forecast to 2019 2Blame it on the astrocytes 2Ten Members of the American Academy of Forensic Sciences Appointed to Forensic Science Standards Board (FSSB) 2Ten Members of the American Academy of Forensic Sciences Appointed to Forensic Science Standards Board (FSSB) 3
... Juvenile Diabetes Research Foundation, a leader in setting the ... will begin a diabetes research collaboration with Pfizer, Hadassah ... drugs to replicate and regenerate insulin-producing cells in people ... the direction of Professor Benjamin Glaser (Hadassah Medical) and ...
... Medical Center have identified a new growth factor that ... cells in culture and in laboratory animals. The discovery, ... help researchers overcome one of the most frustrating barriers ... are so few in number and so stubbornly resistant ...
... Spanish . , Feeding the amino acid tryptophan ... makes them less aggressive and easier to manage, according to ... The tryptophan-enhanced diet reduced aggression and overall behavioral activity ... is only acquired through diet, is the precursor for the ...
Cached Biology News:JDRF, Pfizer, Hadassah Medical and the Hebrew University announce collaboration 2Newly identified growth factor promotes stem cell growth, regeneration 2Tryptophan-enriched diet reduces pig aggression 2
(Date:7/12/2014)... 12, 2014 This report ... used in the life science industry. Continuous ... science reagents market towards remarkable growth. The ... providers of life science reagents. , Brows ... http://www.transparencymarketresearch.com/life-sciences-reagents-analytical-reagents.html . , The global life science ...
(Date:7/11/2014)... DUBLIN , July 11, 2014 ... "International Transfection Technology Market - Global Industry Analysis, ... report to their offering. ... to introduce nucleic acids (either DNA or RNA) into ... therapy, mutation of cancer cells and protein metabolism by ...
(Date:7/11/2014)... 2014 /CNW/ - Sunovion Pharmaceuticals Canada Inc. (Sunovion) today ... acetate) for use as a once-daily adjunctive therapy for ... who are not satisfactorily controlled with conventional therapy.  APTIOM ... under 18 years of age. Epilepsy ... according to Epilepsy Canada, it affects 0.6% of the ...
(Date:7/10/2014)... Faso (PRWEB) July 10, 2014 ... today have access to an additional family planning ... access to contraception at all levels of the ... lower-dose formulation of a widely used contraceptive—Pfizer’s Depo-Provera® ... , Burkina Faso is the first of four ...
Breaking Biology Technology:Transparency Market Research: Life Science Reagents Market- PCR Reagent Kits, Cell and Tissue Culture, Flow Cytometry, Electrophoresis and Chromatography 2Transparency Market Research: Life Science Reagents Market- PCR Reagent Kits, Cell and Tissue Culture, Flow Cytometry, Electrophoresis and Chromatography 3International Transfection Technology Market - Industry Analysis, Size, Share, Growth, Trends and Forecast to 2019 2Sunovion Pharmaceuticals Canada Inc. Announces Health Canada Approval of APTIOM(TM) (eslicarbazepine acetate) as a Once-Daily Adjunctive Treatment for Partial-Onset Seizures in Patients with Epilepsy 2Sunovion Pharmaceuticals Canada Inc. Announces Health Canada Approval of APTIOM(TM) (eslicarbazepine acetate) as a Once-Daily Adjunctive Treatment for Partial-Onset Seizures in Patients with Epilepsy 3Sunovion Pharmaceuticals Canada Inc. Announces Health Canada Approval of APTIOM(TM) (eslicarbazepine acetate) as a Once-Daily Adjunctive Treatment for Partial-Onset Seizures in Patients with Epilepsy 4Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 2Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 3Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 4Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 5Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 6
... TurboSonic,Technologies, Inc. (OTC Bulletin Board: TSTA), a global ... control technologies, today,announced that the company,s CEO, Edward Spink ... Show., The interview gives viewers an overview of ... release., To view the clip ...
... sinus irrigation device) describes his successful treatment protocol for ... cavities using a pulsating irrigation device. This treatment has ... of sinus infections, snoring and sleep apnea., http://abclocal.go.com/kabc/story?section=news/health&id=6231390 ... ...
... Department of Labor Conference, WEST PALM BEACH, ... Department of Labor,s Recognition of Excellence Award in,the ... Deputy Assistant Secretary of Labor for Employment and,Training, ... honors,workforce investment programs from around the country that ...
Cached Biology Technology:[video] Edward Spink, CEO of TurboSonic Technologies, Inc. Discusses Contract With Biofuel Producer in Exclusive Interview on WallSt.net's 3-Minute Press Show 2Prominent Physician Achieves Success Using Topical Sinus Medications via Pulsitile Irrigation 2Workforce Alliance Receives U.S. Labor Department's Excellence Award 2Workforce Alliance Receives U.S. Labor Department's Excellence Award 3
Anti Autotaxin /ENPP2 , - (Rabbit)...
...
... 2-Deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose Pale yellow solid. An ... a nitric oxide donor in pancreatic ... bacteria. Causes DNA alkylation and DNA ... Purity: ≥95% by HPLC. Soluble in ...
... a silica based spin filter membrane to isolate ... DNA band is cut from an agarose gel ... The gel slice is melted irreversibly in a ... bound to the silica spin filter membrane and ...
Biology Products: