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Tumor-suppressor gene is critical for placenta development

ing both genes lived three days longer than the embryos missing Rb only, but all died before birth.

"This showed that the interaction of these two proteins is definitely important," Leone says. "It strongly suggests that E2f3 is a key player in mediating Rb function in stem cells and possibly in its role as a tumor suppressor."

Next, Leone and his colleagues want to know if the Rb gene is important in miscarriages.

"Miscarriages have never been linked to a gene defect, but understanding the genetic basis of miscarriage would be a hugely important," Leone says. "It would be the first link between a gene mutation, placental function and development."


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Source:Ohio State University


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