Navigation Links
Tumor cells that border normal tissue are told to leave

he study demonstrated that it was the difference in Src activity that led to the change in the attachment proteins. When a high Src cell (tumor cell) was next to a low Src cell (normal cell) the attachment proteins changed their characteristics, and the high Src cell became "unglued."

In addition, this change sent a signal that activated several other proteins in the tumor cell, one of which was an enzyme that dissolves the matrix surrounding cells. This enzyme makes it possible for a cell to move through tissues.

"Even though all the cells in the tumors we created were genetically identical, the proximity of the boundary cells to normal cells--their interaction with normal cells--made them special," Vidal says. "This is the first time the epithelial environment has been shown to play a role in metastasis."

The cells that left the fruit fly tumors eventually succumbed to the natural process of programmed cell death and were eliminated. According to Cagan, that was not unexpected.

"In a tumor, probably 99.99 percent of the border cells are raining out of the edges and dying," Cagan says. "But as oncologists have found, cancer stems from an accumulation of genetic mutations. If one of these wandering cells acquires a second mutation that prevents cell death, it could go on to establish a metastatic tumor."

Having created a model for studying metastasis of tumor cells, the research team has begun to look for ways to manipulate boundary cells to prevent their metastatic behavior. They have seen that disabling some of the genes in the pathway activated in boundary cells stops the cells from leaving the tumor.

Cagan's laboratory also has developed a robotic system for screening anticancer drugs, and they plan to use this system to look for drugs that will affect the metastatic process in their fruit fly model.

"A drug that can prevent metastasis would be an important adjunct for cancer treatments," Cagan says. "It co
'"/>

Source:Washington University School of Medicine


Page: 1 2 3

Related biology news :

1. Missing Receptor Molecule Causes Tumor Growth
2. Stem Cells Found In Cerebellum; Possible Cell of Origin for Childhood Brain Tumors
3. New Therapeutic Target Identified In Inherited Brain Tumor Disorder
4. Tumor wizardry wards off attacks from the immune system
5. Tumor cells evade death through autophagy
6. Tumor-suppressor gene is critical for placenta development
7. Wisconsin scientists grow critical nerve cells
8. Spleen may be source of versatile stem cells
9. Researchers discover way to make cells in the eye sensitive to light
10. Priming embryonic stem cells to fulfill their promise
11. Lack of enzyme turns fat cells into fat burners
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Tumor cells that border normal tissue are told leave

(Date:4/14/2015)... , April 14, 2015 NXT-ID, Inc. ... biometric authentication company focused on the growing mobile commerce ... nominated for the 2015 New York Design Awards under ... Design100, New York City Design Awards are part of ... on over 2,500 ratings from the marketplace, industry and ...
(Date:4/9/2015)... 9, 2015 Synaptics Inc. (NASDAQ: SYNA ), ... that it will report financial results for the third ... after the close of market. The company will host ... 2:00 p.m. PT (5:00 p.m. ET), during which management ... on the live call, analysts and investors should dial ...
(Date:4/2/2015)... -- At its 2015 ACMG Annual Clinical Genetics Meeting ... American College of Medical Genetics and Genomics (ACMG) announced ... Members of the ACMG Board of Directors serve as ... its policies and programs. ACMG is the national organization ... eventful time in medical genetics and genomics.  We are ...
Breaking Biology News(10 mins):NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 2NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 3Synaptics to Report Third Quarter Results on April 23 2American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 2American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 3American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 4American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 5American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 6American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 7American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 8
... say they have assembled more completely the string of ... to imitate their owners and other sounds. The ... genome using a new technology, single molecule sequencing, and ... The team also decoded hard-to-sequence genetic material from corn ...
... known to both eat and inhabit dead whale skeletons ... unique ability to release bone-melting acid, scientists at Scripps ... recently discovered. The work is being presented at the ... Dr Sigrid Katz, a postdoctoral researcher working ...
... the average three year life span of a common rat, ... rat, a subterranean rodent native to East Africa, is impressive. ... rodent shows little decline due to aging, maintaining high activity, ... Now a collaborative of researchers in Israel and the United ...
Cached Biology News:DNA sequenced for parrot's ability to parrot 2DNA sequenced for parrot's ability to parrot 3Acid-wielding worms drill through bones at the bottom of the sea 2Naked mole rat may hold the secret to long life 2
(Date:5/4/2015)...  Soligenix, Inc. (OTCQB: SNGX) (Soligenix or the Company), ... medical needs in the areas of inflammation, oncology and ... data from three of its biodefense programs at the ... on May 12-14, 2015 to be held at the ... St. Louis MO 63101. ...
(Date:5/4/2015)...   Sentrian ™, the Remote Patient Intelligence™ company ... Scripps Translational Science Institute (STSI) to study ... chronic obstructive pulmonary disease (COPD), a chronic condition that ... third leading cause of death. The patients are all ... a wholly owned subsidiary of Anthem.   ...
(Date:5/1/2015)... May 1, 2015 Pfenex Inc. (NYSE ... the development of biosimilar therapeutics including high value ... its first quarter 2015 financial results will be ... open of market. At 8:30 am Eastern Time, Pfenex ... the financial results and provide a business update. A ...
(Date:5/1/2015)... May 1, 2015 According ... Market by Product (Equipment, Consumables), by Type (Monoclonal, Polyclonal), ... Labs, Research Institutes) - Analysis & Global Forecast ... the global Antibody Production Market for the forecast ... expected to reach $2.572 Billion by 2019 from ...
Breaking Biology Technology:Soligenix Announces Presentation and Poster at the 2015 Chemical and Biological Defense Science and Technology Conference in St. Louis, MO 2Soligenix Announces Presentation and Poster at the 2015 Chemical and Biological Defense Science and Technology Conference in St. Louis, MO 3Soligenix Announces Presentation and Poster at the 2015 Chemical and Biological Defense Science and Technology Conference in St. Louis, MO 4Soligenix Announces Presentation and Poster at the 2015 Chemical and Biological Defense Science and Technology Conference in St. Louis, MO 5Soligenix Announces Presentation and Poster at the 2015 Chemical and Biological Defense Science and Technology Conference in St. Louis, MO 6Soligenix Announces Presentation and Poster at the 2015 Chemical and Biological Defense Science and Technology Conference in St. Louis, MO 7Soligenix Announces Presentation and Poster at the 2015 Chemical and Biological Defense Science and Technology Conference in St. Louis, MO 8Soligenix Announces Presentation and Poster at the 2015 Chemical and Biological Defense Science and Technology Conference in St. Louis, MO 9Soligenix Announces Presentation and Poster at the 2015 Chemical and Biological Defense Science and Technology Conference in St. Louis, MO 10Soligenix Announces Presentation and Poster at the 2015 Chemical and Biological Defense Science and Technology Conference in St. Louis, MO 11Soligenix Announces Presentation and Poster at the 2015 Chemical and Biological Defense Science and Technology Conference in St. Louis, MO 12CareMore, Scripps Translational Science Institute, and Sentrian Launch Landmark Study of Remote Patient Monitoring for COPD Population 2CareMore, Scripps Translational Science Institute, and Sentrian Launch Landmark Study of Remote Patient Monitoring for COPD Population 3CareMore, Scripps Translational Science Institute, and Sentrian Launch Landmark Study of Remote Patient Monitoring for COPD Population 4CareMore, Scripps Translational Science Institute, and Sentrian Launch Landmark Study of Remote Patient Monitoring for COPD Population 5Pfenex To Report First Quarter 2015 Results and Provide Business Update on Thursday, May 14, 2015 2Antibody Production Market worth $2.572 Billion by 2019 2Antibody Production Market worth $2.572 Billion by 2019 3Antibody Production Market worth $2.572 Billion by 2019 4
... BNVI ), a leader in the discovery and development ... and cancer, today announced,that Tom Chesterman, SVP and CFO of ... The presentation will take place on October 11, 2007 ... CA. A live audio web cast and slide presentation ...
... MEETING, Pa., Oct. 5 Genaera,Corporation (Nasdaq: ... be,presenting at two upcoming conferences, Biotech 2007 in ... in San Francisco on October,9-11, 2007. Henry ... Scientific,Officer of Genaera, is scheduled to participate in ...
... molecular structure found in seashells, University of Michigan researchers ... but lighter and transparent. , It,s made of ... shares chemistry with white glue. , Engineering professor Nicholas ... material isn,t quite stretchy enough to earn that name. ...
Cached Biology Technology:Genaera to Present at Biotech 2007 and BIO InvestorForum 2Genaera to Present at Biotech 2007 and BIO InvestorForum 3U-M research: New plastic is strong as steel, transparent 2
Human ABCG2 MAb (Clone 5D3)...
Standard 2" and 3" Fiberboard Boxes can be sold separately or with 16, 25, 36, 49, 64, 81 or 100 cell dividers. Fiberboard boxes can also be ordered with corresponding freezer racks...
Although each Beacon 2000 System includes one preinstalled sample chamber (size specified at time of order), optional chambers are available and easily retrofit by the user....
... technology incorporating the sophisticated DirectDrive architecture ... new Varian NMR System is undeniably ... ,The Varian NMR System features parallel ... channel, providing pulse sequence programming power ...
Biology Products: