Navigation Links
Trojan horse strategy defeats drug-resistant bacteria

A new antimicrobial approach can kill bacteria in laboratory experiments and eliminate life-threatening infections in mice by interfering with a key bacterial nutrient, according to research led by a University of Washington scientist. The joint project, conducted at the UW, the University of Iowa, and the University of Cincinnati, will be featured in the April 2 issue of the Journal of Clinical Investigation.

Bacteria are increasingly resistant to antibiotics, and existing drugs work poorly against chronic infections like those that occur in wounds, on medical devices and in the lungs of people with cystic fibrosis. For these reasons, a great deal of research is focused on finding new antibiotic compounds.

In this study, researchers took a different approach. Rather than trying to find agents that best killed bacteria in test tubes, they sought to intensify the stress imposed on microbes by one of the body's own defense mechanisms.

"The competition for iron is critical in the struggle between bacteria and host," explained the study's senior author, Pradeep Singh, associate professor of medicine and microbiology at the UW. "The body has potent defense mechanisms to keep iron away from infecting organisms, and invaders must steal some if they are to survive."

Iron is critical for the growth of bacteria and for their ability to form biofilms, slime-encased colonies of microbes that cause many chronic infections. "Because iron is so important in infection, we thought infecting bacteria might be vulnerable to interventions that target iron," explained Yukihiro Kaneko, senior fellow in microbiology at the UW and the study's lead author.

To accomplish this, the researchers used gallium, a metal very similar to iron.

"Gallium acts as a Trojan horse to iron-seeking bacteria," said Singh. "Because gallium looks like iron, invading bacteria are tricked, in a way, into taking it up. Unfortunately for the bacteria,
'"/>

Source:University of Washington


Page: 1 2

Related biology news :

1. Killing brain tumors from within: A Trojan horse approach
2. Trojan Horse agent halts bone metastasis in mice
3. Live vaccines more effective against horse herpes virus
4. Ancient DNA helps clarify the origins of two extinct New World horse species
5. New evidence of early horse domestication
6. Gene silencing technique offers new strategy for treating, curing disease
7. AIDS expert says global strategy needed to combat feminization of HIV/AIDS
8. Asleep in the deep: Model helps assess ocean-injection strategy for combating greenhouse effect
9. Melanoma vaccine strategy shows promise in laboratory experiments
10. Study by Einstein researchers could lead to a novel strategy for treating obesity
11. Team discovers possible universal strategy to combat addiction
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Trojan horse strategy defeats drug resistant bacteria

(Date:4/17/2014)... eight hundred births, Down syndrome - or trisomy 21 ... disability. It results from a chromosomal abnormality where cells ... 21 (1% of the human genome). A study conducted ... of Genetic Medicine and Development at the University of ... , shed light on how the extra chromosome 21 ...
(Date:4/17/2014)... Singh Thursday as a "Champion of Change" for ... in the residential, commercial and industrial sectors. , ... and Computer Engineering and director of Clemson,s Center ... leading the charge across the country to create ... driving policy changes at the local level to ...
(Date:4/17/2014)... implicated in many serious conditions such as heart disease, ... for drug therapies. Unfortunately, there is still much scientists ... provides fresh and unexpected insight into the structure of ... β-subunit molecules - which are responsible for ,fine-tuning, the ... the most recent edition of the Journal of ...
Breaking Biology News(10 mins):Trisomy 21: How an extra little chromosome throws the entire genome off balance 2Trisomy 21: How an extra little chromosome throws the entire genome off balance 3White House honors Clemson professor as 'Champion of Change' for solar deployment 2Structure of sodium channels different than previously believed 2
... , ,Mathematical models continue to play a major ... and control of malaria, a life-threatening parasitic disease ... Although existing models have advanced our understanding of ... new challenges., The National Institute for Mathematical and ...
... JOLLA, CA January 18, 2011 Using chemical compounds ... clever application of ultraviolet light, a Scripps Research Institute team ... to test for biomedical potential. Already, one of the compounds ... and fighting inflammation. With the report of their ...
... how the hormones progesterone and estrogen interact to increase ... a novel finding that may explain why postmenopausal women ... at increased risk of breast cancer. The discovery ... the increased production of the protein amphiregulin, which binds ...
Cached Biology News:Malaria modeling and control focus of workshop 2Scripps Research team creates new synthetic compound with HIV-fighting promise 2Scripps Research team creates new synthetic compound with HIV-fighting promise 3Researchers unlock how progesterone increases breast cancer risk 2
(Date:1/14/2014)... BETHESDA, Md. , Jan. 14, 2014 ... two institutes from the National Institutes of Health (NIH) ... safer, more effective treatments to patients on a faster ... Advancing Translational Sciences (NCATS) and the National Eye Institute ...
(Date:1/14/2014)... Toronto, Canada (PRWEB) January 14, 2014 ... and its motives and methods in product development and ... of the industry. This mistrust, fueled by concerns about ... further fed by reports of spectacular fines to the ...
(Date:1/14/2014)... 2014 Global Record Systems, LLC, ... technology solutions for patients, physicians, the biopharmaceutical industry, ... today the signing of a three-year Research Collaboration ... Administration (FDA). This initiative is designed to ...
(Date:1/14/2014)... and Cardiff, UK (PRWEB) January 13, 2014 ... development leader with more than 20 years in the ... optics and photonics . Hainsey will serve as the ... to have Dr. Hainsey join SPIE as our Technology ...
Breaking Biology Technology:Organovo Announces Collaboration with National Institutes of Health 2Organovo Announces Collaboration with National Institutes of Health 3The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 2The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 3Global Record Systems Announces Research Collaboration Agreement with FDA to Create a Novel “Big Data” Paradigm for Collection of Patient Safety and Outcomes Information 2Photonics R&D Leader Bob Hainsey Joins SPIE Technical Staff 2
... Thera, Inc.,announced today that the United States Patent ... "Protein-fragment Complementation,Assays (PCA) in whole animals: applications to ... gene therapy." This is the,twelfth patent issued for ... a method for detecting protein-protein,interactions in living cells ...
... Dec. 12 Genaera,Corporation (Nasdaq: GENR ) today ... Genaera, is scheduled to present at the 2007,RBC Capital ... Capital Markets, panel discussion of diabetes and obesity, entitled,"The ... place in,New York on Thursday, December 13 at 10:00 ...
... (OTC,Bulletin Board: BMOD) ( http://www.biomoda.com ) of Albuquerque, ... (New Mexico Tech at, http://www.nmt.edu ) reached an ... development of specialized image recognition technology as,part of ... early,detection of lung cancer., New Mexico Tech, ...
Cached Biology Technology:Odyssey Thera Granted U.S. Patent for Animal Imaging 2Biomoda Announces Collaborative Agreement With New Mexico Tech 2