Navigation Links
'Trojan Horse' agent halts bone metastasis in mice

press the Flt-1 receptor.

According to Rosenblum, the VEGF121/rGel agent entered the immature cells via the Flt-1 receptor and destroyed them, shutting down tumor growth. "This was a surprise to us," he says. "We had not expected these cells to be killed at all because we knew, through our earlier experiments, that VEGF121/rGel destroyed blood vessels by entering a different cell surface receptor, one which is not expressed on pre-osteoclasts."

Thus, in the bone, VEGF121/rGel may be working through two different VEGF receptors. It stops the bone destruction needed for the cancer to grow and may inhibit blood vessel growth to the metastasized tumor, Rosenblum says.

"The fact that this form of VEGF targeting works on different cell receptors in blood vessels and in bone cells is a unique finding that could be clinically significant, not only to treating cancer but other bone disorders," he says. "In the least, this study helps us understand more about how VEGF operates inside the body and how it is involved in bone remodeling."

Rosenblum said that phase I human clinical trials testing VEGF121/rGel are expected to open shortly at M. D. Anderson.
'"/>

Source:University of Texas M. D. Anderson Cancer Center


Page: 1 2 3

Related biology news :

1. Killing brain tumors from within: A Trojan horse approach
2. New drug shows promise as powerful anticancer agent
3. To control germs, scientists deploy tiny agents provocateurs
4. Gadonanotubes greatly outperform existing MRI contrast agents
5. Tiny avalanche photodiodes target bioterrorism agents
6. Software agents could help unmask reality of disease clusters
7. Mouse study: New muscle-building agent beats all previous ones
8. Chemical warfare agent detection technology used to treat lung disease
9. Got inexpensive contrast agent? Milk plays new role in imaging
10. Failed experiment yields a biocontrol agent that doesnt trigger antibiotic resistance
11. Gallium: A new antibacterial agent?
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Trojan Horse agent halts bone metastasis mice

(Date:5/19/2015)... Sweden , May 18, 2015 ... fingerprint sensors FPC1020, FPC1025, FPC1145, FPC1155 and FPC1035 from one ... from June until and including Q3 2015 and the sensors ... . Communicated order values for 2015 hereby amount to ... for Q1 2015 of 140 MSEK and a number of ...
(Date:5/14/2015)... , May 14, 2015  Verificient Technologies, ... verification and online remote proctoring, announced a ... (SaaS) company and creator of the Canvas ... the two companies will benefit from the ... As a fully integrated multifactor ...
(Date:5/8/2015)... , May 8, 2015 Synaptics Inc. (NASDAQ: ... today announced that members of the executive management team will ... 43rd Annual Technology, Media and Telecom Conference Date: May ... in Boston, MA Cowen ... 2015 Time: 2:45pm ET Location: The New York Palace Hotel, ...
Breaking Biology News(10 mins):Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 230 Million and Raises Revenue Guidance for 2015 2Verificient and Instructure Announce Alliance Partnership to Provide Online Proctoring for K-12 and Higher Education Institutions 2Synaptics to Present at Upcoming Investor Conferences 2
... Assistance in Area of National Need program has awarded ... to support a new graduate fellowship training program in ... next three years. An additional 25 percent match ... Biology and K-State,s office of research and sponsored programs, ...
... University scientists have won a $1.5 million grant from ... A virus for clues that could lead to more ... year,s pandemic H1N1 variety, some seasonal varieties and the ... biochemists in the laboratory of Rice,s Jane Tao will ...
... are created each time a cell divides, they are not ... differ in the way they regulate them. New research now ... are directly linked to how they prepare for their next ... and the State University of New York, Stony Brook, may ...
Cached Biology News:K-State receives more than $780,000 to fund graduate students studying ecology, evolution, genomics 2Flu focus: NIH project aims for better drugs 2Checkered history of mother and daughter cells explains cell cycle differences 2Checkered history of mother and daughter cells explains cell cycle differences 3
(Date:5/25/2015)... BOSTON , May 26, 2015  PureTech, a ... toughest health challenges in disruptive ways, announced today that ... Foundation and former CEO of Pearson, has been appointed ... Senior Independent Director and that current Board member ... appointed Board Chairman. Dr. Ben Shapiro , PureTech,s ...
(Date:5/22/2015)... DUBLIN , May 22, 2015  Actavis plc ... of the U.S. Court of Appeals for the Second ... 2014 preliminary injunction requiring the Company to continue distribution ... Logo - http://photos.prnewswire.com/prnh/20130124/NY47381LOGO   ... uphold this ruling, we intend to continue our strong ...
(Date:5/22/2015)... Baylor Research Institute (BRI) at Dallas ... in Phoenix, AZ , today announce ... treatments for patients with a broad range of cancers. Aligning ... clinical trials and access to technology to drive the development ... bedside across Baylor Scott & White Health,s 49 ...
(Date:5/21/2015)... 2015  Susan Hedstrom, Executive Director of the ... dedicated to supporting research to advance the understanding ... that FPWR has received the organization,s largest donation ... contributed $1 million in support of the organization,s ... "Our gift signifies our tremendous ...
Breaking Biology Technology:PureTech Adds Dame Marjorie Scardino to Board of Directors, Names Joi Ito as Chairman of the Board and Expands Management Team 2PureTech Adds Dame Marjorie Scardino to Board of Directors, Names Joi Ito as Chairman of the Board and Expands Management Team 3Actavis Confirms Appeals Court Ruling Requiring Continued Distribution of NAMENDA IR 2Actavis Confirms Appeals Court Ruling Requiring Continued Distribution of NAMENDA IR 3Actavis Confirms Appeals Court Ruling Requiring Continued Distribution of NAMENDA IR 4Actavis Confirms Appeals Court Ruling Requiring Continued Distribution of NAMENDA IR 5Actavis Confirms Appeals Court Ruling Requiring Continued Distribution of NAMENDA IR 6Actavis Confirms Appeals Court Ruling Requiring Continued Distribution of NAMENDA IR 7Actavis Confirms Appeals Court Ruling Requiring Continued Distribution of NAMENDA IR 8Precision Medicine Collaboration to Increase Options for Cancer Patients 2Precision Medicine Collaboration to Increase Options for Cancer Patients 3Precision Medicine Collaboration to Increase Options for Cancer Patients 4The Foundation for Prader-Willi Research Receives $1M Contribution in Support of Clinical Initiatives 2
... SARcode Corporation has named Todd Creech as Chief Financial ... 1, 2011. Creech has been fulfilling both positions as ... (Photo: http://photos.prnewswire.com/prnh/20110214/FL47222LOGO ) "Todd ... finance and leadership roles and has demonstrated great success ...
... with phosphorus, a critical element in fertilizers and food, ... "can,t get no respect." Increasingly scarce, yet ... this essential component of our bones, our DNA, the ... oil on the endangered species list without change ...
... today announced the public launch of the Tufts Institute ... The Institute is a university-wide, global pharmaceutical ... portfolio of drug discovery and development partnerships. ... Tufts University School of Medicine and Tufts University,s Advancement ...
Cached Biology Technology:Todd A. Creech Named Chief Financial Officer and Vice President of Business Development for SARcode Corporation 2Todd A. Creech Named Chief Financial Officer and Vice President of Business Development for SARcode Corporation 3P Summit calls for a 'new alchemy' around phosphorus and food 2P Summit calls for a 'new alchemy' around phosphorus and food 3P Summit calls for a 'new alchemy' around phosphorus and food 4Tufts Launches Institute for Biopharmaceutical Partnerships 2Tufts Launches Institute for Biopharmaceutical Partnerships 3Tufts Launches Institute for Biopharmaceutical Partnerships 4
Sheep polyclonal to Melatonin ( Abpromise for all tested applications). Antigen: Melatonin Tg conjugate....
Goat polyclonal to DDDDK tag (FITC) ( Abpromise for all tested applications)....
...
DNA fragmentation factor & Inhibitor of CAD...
Biology Products: