Navigation Links
'Tribbles' protein implicated in common and aggressive form of leukemia

Researchers at the University of Pennsylvania School of Medicine have identified a new protein associated with acute myelogenous leukemia (AML). Several lines of evidence point to a protein called Tribbles, named after the furry creatures that took over the starship Enterprise in the original Star Trek series. Tribbles was first described in fruit flies.

"Tribbles had never been directly linked to human malignancy," says senior author Warren S. Pear, MD, PhD, Associate Professor of Pathology and Laboratory Medicine. "This is a new protein to human cancer and has a specific and overwhelming effect when expressed in hematopoietic stem cells, the cell type that gives rise to all elements of the blood."

Three lines of evidence implicate Tribbles in AML. First, all mice engineered to express Tribbles-2 (Trib-2) in hematopoietic stem cells developed AML. They also found that Trib-2 inhibited C/EBPá, another protein that is frequently mutated in AML patients. Additionally, expression of the Tribbles protein was elevated in blood samples from AML patients, further suggesting that it contributes to AML. Overall, the findings suggest that Tribbles induces AML by inactivating the C/EBPá protein. The results were published in this week's issue of Cancer Cell.

AML is a malignancy that arises in white blood cells and develops when there is a defect in immature immune cells in the bone marrow. In AML, the uncontrolled, exaggerated growth and accumulation of white blood cells leads to anemia and a deficiency of normal white cells in the blood. AML is the most common type of leukemia in adults, with an estimated 10,100 new cases reported each year.

Pear, also a researcher in the Abramson Family Cancer Research Institute at Penn; first author and postdoctoral fellow Karen Keeshan, PhD; and colleagues found Tribbles by chance when looking for the molecular partners of another protein called Notch. Notch is a molecular switch of sorts, activati
'"/>

Source:University of Pennsylvania School of Medicine


Page: 1 2

Related biology news :

1. New, automated tool successfully classifies and relates proteins in unprecedented way
2. New binding target for oncogenic viral protein
3. Controversial drug shown to act on brain protein to cut alcohol use
4. Timing is everything: First step in protein building revealed
5. UWs Rosetta software to unlock secrets of many human proteins
6. Researchers find how protein allows insects to detect and respond to pheromones
7. Signaling protein builds bigger, better bones in mice
8. Ancient olfaction protein is shared by many bugs, offering new pest control target
9. Automatic extraction of gene/protein biological functions from biomedical text
10. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
11. Scientists develop new color-coded test for protein folding
Post Your Comments:
(Date:9/23/2014)... Ill. Antarctic fishes that manufacture their own ... Ocean also suffer an unfortunate side effect, researchers ... their bodies resist melting even when temperatures warm. ... Proceedings of the National Academy of Sciences ... an undesirable consequence of the evolution of antifreeze ...
(Date:9/23/2014)... has domesticated animals, selecting the best traits possible ... an intriguing animal to examine adaptation to climate ... selected breeding and a wealth of livestock genome-wide ... study that combined molecular and environmental data, professor ... genes under environmental selection from domesticated sheep breeds. ...
(Date:9/23/2014)... successful rise and fall of an athlete,s moving body relies ... putting the many angles and intersecting planes literally the ... to the test. But it,s more than just a footfall ... of sports injuries: the ACL or anterior cruciate ligament tear. ... at the center of the knee joint and volume ...
Breaking Biology News(10 mins):Study: Antifreeze proteins in Antarctic fishes prevent freezing ... and melting 2Study: Antifreeze proteins in Antarctic fishes prevent freezing ... and melting 3Being sheepish about climate adaptation 2Does size matter? MRI imaging sheds light on athletes most at risk for severe knee injury 2Does size matter? MRI imaging sheds light on athletes most at risk for severe knee injury 3
... in 100 inhabitants died from Spanish flu in 1918, but ... An important explanation for the differences is due to different ... came. Those living in urban communities probably had a higher ... in 1918 than those living in very isolated rural areas. ...
... other businesses step up efforts to cut waste, reduce ... products and processes, the number of planet-friendly standards and ... a sometimes-confusing array of options for "going green." National ... a framework to help organizations of all types sort ...
... Article highlights from the May issue of The American Naturalist ... a second, Genes control fruit flies, social groupings, What can twins ... issue table of contents, go to www.journals.uchicago.edu/an . ... kstacey@press.uchicago.edu . Cuttlefish: From camo to tuxedo ...
Cached Biology News:Large differences in mortality between urban and isolated rural areas 2Large differences in mortality between urban and isolated rural areas 3NIST prototypes framework for evaluating sustainability standards 2Tipsheet for the May issue of the American Naturalist 2Tipsheet for the May issue of the American Naturalist 3
(Date:9/23/2014)... Carolina (PRWEB) September 24, 2014 Spirax ... trap constructed to withstand corrosion from clean and ... ASME standards and is designed to remove condensate from ... ideal for the pharmaceutical, biotechnology, and food and beverage ... to steam saturation temperatures, reducing condensate back up and ...
(Date:9/23/2014)... University of Texas at Austin and Northwestern University ... reliability and performance of transistors and circuits based ... has long been considered by scientists as one ... smaller, faster and cheaper electronic devices. The result ... journal Applied Physics Letters , from AIP ...
(Date:9/23/2014)... the University of Southampton,s Optoelectronics Research Centre (ORC) ... potential challenger to graphene. , Graphene, a single ... is increasingly being used in new electronic and ... sources, thanks to the unprecedented properties it offers: ... mechanically stretchable yet harder than diamond. , Now, ...
(Date:9/23/2014)... ceramics have potential uses as ferroelectrics, fast ion ... waste, generating a great deal of scientific interest ... blended materials. , "The interfaces separating the different ... properties of the material as a whole," said ... on the project. "It is in the chemical ...
Breaking Biology Technology:Spirax Sarco Announces the BTS7.1 Stainless Steel Clean Steam Trap 2Future flexible electronics based on carbon nanotubes 2Future flexible electronics based on carbon nanotubes 3Future flexible electronics based on carbon nanotubes 4Southampton scientists grow a new challenger to graphene 2Los Alamos researchers uncover properties in nanocomposite oxide ceramics for reactor fuel 2
... Calif., Feb. 6 Onyx,Pharmaceuticals, Inc. (Nasdaq: ... the BIO CEO & Investor Conference on Wednesday, ... may access a live webcast of the,presentation at:, ... log on 15 minutes early in order to,register ...
... Avatar Software Platform Further Solidifies Netsmart as Leader in Behavioral ... ... Florida, GREAT RIVER, N.Y., Feb. 6 Netsmart Technologies, ... services organizations, today announced it has signed a contract to,provide comprehensive ...
... Global Probiotics Council,(GPC), a committee established in 2004 ... the Young Investigator Grant for probiotics research,program (YIGPRO) ... stimulate,innovative research and to support young investigators and ... field of probiotics and gut,microbiota., "Our two ...
Cached Biology Technology:Netsmart Technologies Extends Relationship with Manatee Glens for Enterprise Behavioral Health Software Solutions 2Netsmart Technologies Extends Relationship with Manatee Glens for Enterprise Behavioral Health Software Solutions 3Global Probiotics Council Announces Young Investigator Grant for Probiotics Research to Fund the Next Generation of Gut Microbiota Research 2Global Probiotics Council Announces Young Investigator Grant for Probiotics Research to Fund the Next Generation of Gut Microbiota Research 3Global Probiotics Council Announces Young Investigator Grant for Probiotics Research to Fund the Next Generation of Gut Microbiota Research 4
Umbilical cord blood CD4+ T cells, For immunohistochemistry (IHC) Cell Chip with Human Umbilical Cord Blood MNCs and T Cells...
Human peripheral blood CD14+ monocytes, For immunohistochemistry (IHC) Cell Chip with Human Peripheral Blood Monocytes, B Cells, NK Cells and Stem Cells...
Human endothelial progenitor cells, For immunohistochemistry (IHC) Cell Chip with Human Peripheral Blood Dendritic Cells and EPCs...
Yeast tRNA 50 l...
Biology Products: