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Trials for new drug to overcome HIV

have shown that the drug defeats strains of HIV which are resistant to other anti-HIV drugs. A small human trial of the drug, reported last August, showed that when given on its own it rapidly clears most HIV from the blood, driving down the levels tenfold in a matter of hours.

The trial planned for this month is intended to discover how the drug performs as part of a combination treatment with other anti-HIV drugs, which is a more realistic situation. Fortyeight patients whose existing drug regimes are failing will receive either PA-457 or a placebo in addition to their standard drugs. There are plans to try the drug along with new regimes tailored to individual patients, though Allaway warns that larger trials are needed and PA-457 will not reach the market until 2009 at the earliest.

Other HIV researchers are also enthusiastic about PA-457. "It's a truly novel new class of drugs, and I really support their development," says Charles Boucher of the University Hospital Utrecht in the Netherlands. "If [PA-457] turns out to be non-toxic, easy to use and not to select for resistance, it will find good use," he says.


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Source:New Scientist


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