Navigation Links
Trials for new drug to overcome HIV

A new drug that could help overcome HIV�fs growing resistance to existing antiviral drugs is about to be tested in combination with standard antivirals. Called PA-457, it is the first of a new class of anti-HIV compounds called maturation inhibitors. The drug is still in its early stages, and will not be generally available for at least three years.

Up to 80 per cent of HIV positive people on treatment show resistance to one or more of their drugs, according to Graham Allaway of Panacos Pharmaceuticals in Gaithersburg, Maryland, which is developing PA-457. Panacos hopes to begin trials this month to test how well the drug works in patients whose existing drug regimes are failing.

PA-457 aims to overcome this resistance by attacking HIV on new front. Many existing drugs work by blocking reverse transcriptase, an enzyme that enables HIV to replicate within cell. Others disable protease, which helps to assemble the virus into particles that infect other cells.

Recent experiments in collaboration with Michael Sakalian and his colleagues at the University of Oklahoma Health Sciences Center in Oklahoma City have shown that PA-457 works in a different way. It attacks HIV by disrupting formation of a conical shield, called the capsid protein, which stores and protects the RNA heart of the HIV particles as they bud out from infected cells.

The latest research, in which the virus was examined under a microscope, shows that the drug binds to the capsid protein at acrucial stage in its manufacture (Journal of Virology, vol 80, p 5716). Normally, the capsid protein is clipped apart from a major structural protein called the gag protein, and is then assembled into a cone. PA-457 stops it being clipped off, causing it to form a leaky sphere that leaves the core RNA exposed (see Diagram, left). This cripples the virus, preventing it from infecting any other cells once it buds out from the host.

Previous lab experiments on infected human cells have shown that the drug defeats strains of HIV which are resistant to other anti-HIV drugs. A small human trial of the drug, reported last August, showed that when given on its own it rapidly clears most HIV from the blood, driving down the levels tenfold in a matter of hours.

The trial planned for this month is intended to discover how the drug performs as part of a combination treatment with other anti-HIV drugs, which is a more realistic situation. Fortyeight patients whose existing drug regimes are failing will receive either PA-457 or a placebo in addition to their standard drugs. There are plans to try the drug along with new regimes tailored to individual patients, though Allaway warns that larger trials are needed and PA-457 will not reach the market until 2009 at the earliest.

Other HIV researchers are also enthusiastic about PA-457. "It's a truly novel new class of drugs, and I really support their development," says Charles Boucher of the University Hospital Utrecht in the Netherlands. "If [PA-457] turns out to be non-toxic, easy to use and not to select for resistance, it will find good use," he says.


'"/>

Source:New Scientist


Related biology news :

1. FDA Approves Human Hookworm Vaccine for Phase I Safety Trials
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/24/2017)... -- Janice Kephart , former 9/11 Commission ... LLP (IdSP) , today issues the following statement: ... 6, 2017 Executive Order: Protecting the Nation ... instilled with greater confidence, enabling the reactivation of ... are suspended by until at least July 2017). ...
(Date:4/17/2017)... MELBOURNE, Florida , April 17, 2017 ... security technology company, announces the filing of its 2016 Annual Report ... Securities and Exchange Commission. ... Report on Form 10-K is available in the Investor Relations section ... well as on the SEC,s website at http://www.sec.gov . ...
(Date:4/11/2017)... , April 11, 2017 Crossmatch®, ... secure authentication solutions, today announced that it has ... Advanced Research Projects Activity (IARPA) to develop next-generation ... program. "Innovation has been a driving ... Thor program will allow us to innovate and ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... ... Disappearing forests and increased emissions are the main causes of the evolving air ... living in larger cities are affected by air pollution related diseases. , That is ... globally - decided to take action. , “I knew I had to take action ...
(Date:10/10/2017)... DIEGO, CALIF. (PRWEB) , ... October 10, 2017 , ... ... as part of its corporate rebranding initiative announced today. The bold new look ... its reach, as the company moves into a significant growth period. , It will ...
(Date:10/10/2017)... ... October 10, 2017 , ... Dr. Bob Harman, founder and CEO of ... Club. The event entitled “Stem Cells and Their Regenerative Powers,” was ... Dr. Harman, DVM, MPVM was joined by two human doctors: Peter B. Hanson, M.D., ...
(Date:10/10/2017)... ... 10, 2017 , ... USDM Life Sciences , the ... sciences and healthcare industries, announces a presentation by Subbu Viswanathan and Jennifer Jaye ... GxP Validation for Agile Cloud Platforms,” will present a revolutionary approach to achieving ...
Breaking Biology Technology: