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Trial success for diabetic nerve therapy

alled ZFP TFTM to poke life into the patient's own genes and produce a growth factor that has a role in nerve protection and regeneration.

"As the data in the paper demonstrate, we have had some striking success."

The US clinical trials ?carried out by Professor Tomlinson's collaborators at biotech firm Sangamo BioSciences Inc ?have also been encouraging with the only adverse event reported being mild injection-site reaction in four of the 12 diabetic patients tested, all of which resolved quickly.

"We are delighted by the progress of our clinical programme in diabetic neuropathy and by the reception it has received from the medical and scientific community," said Edward Lanphier, Sangamo's President and CEO.

"We believe our DNA-binding protein may provide a novel and much-needed therapeutic approach to diabetic neuropathy and optimistically look forward to the next stage of development of this novel therapeutic when phase-two clinical trials start later this year."

The incidence of diabetes, a condition in which the amount of glucose in the blood is too high, is increasing dramatically with the World Health Organisation estimating that some 300 million people worldwide could be affected by 2025.

The causes of diabetic neuropathy are not fully understood but researchers investigating the effect of glucose on nerves believe it is likely to be a combination of factors.


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Source:University of Manchester


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