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Treatments have same target, different responses for lung cancer patients with genetic mutation

still unanswered. However, they did examine the outcomes of four patients with EGFR mutations in their tumors who had been treated with gefitinib and then cetuximab, or vice versa. They found that all patients displayed partial responses to gefitinib in terms of tumor shrinkage, whereas none of them appeared to respond to cetuximab.

"Overall, our results raise the possibility that NSCLC patients with EGFR mutations may derive the greatest benefit, in terms of tumor regression, if treated with gefitinib rather than with cetuximab," the authors conclude.

"These findings clearly have important clinical implications because both drugs should, theoretically, block EGFR signaling," writes John D. Minna, M.D., of the Hamon Center for Therapeutic Oncology Research at the University of Texas Southwestern Medical Center in Dallas, and colleagues in an accompanying editorial. "The first round clearly was won by [drugs such as gefitinib]." However, they add that additional research should focus on the effects of cetuximab on certain populations of patients, or used in conjunction with other drugs. "Cetuximab may still have an effective punch if the right circumstances can be identified," the authors conclude.


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Source:Journal of the National Cancer Institute


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