Navigation Links
Treating populations infected with HIV and latent TB could speed the emergence of drug-resistant TB

In 2005, 46 regional Ministers of Health in Africa declared that a dramatic rise in tuberculosis (TB) cases was cause for emergency. In some African countries, annual TB case notifications have increased as much as four-fold over the past 15 years. The main culprit? The emergence of HIV. When individuals are infected with both HIV and TB, they are more likely to progress from latent TB infection to active TB.

To combat the problem, the World Health Organization currently recommends that as part of HIV/AIDS programs, patients infected with both HIV and TB be treated with isoniazid, an antimicrobial, as a preventive therapy to reduce the risk that TB will progress from latent infection to active disease. However, researchers from the Harvard School of Public Health (HSPH) and a team of collaborators believe that strategy has flaws. Their findings appear in the advance online edition of the May 2, 2006 issue of Proceedings of the National Academy of Sciences.

The researchers, led by Ted Cohen, doctoral student at HSPH, and senior author Megan Murray, Assistant Professor of Epidemiology, developed a mathematical model to describe the projected impact of isoniazid preventive therapy (IPT) programs on the transmission dynamics of drug-resistant TB in areas where community-wide preventive therapy may be used as a strategy to control TB. They concluded that the implementation of IPT targeted to people co-infected with HIV and TB may also have the perverse effect of speeding the emergence of drug-resistant TB.

"We're not saying isoniazid preventive therapy policies are ill-advised," said Cohen. "But we think they need to be coupled with an understanding that large-scale IPT programs should be ready to diagnose and treat individuals with drug-resistant TB as part of the programs."


'"/>

Source:Harvard School of Public Health


Page: 1

Related biology news :

1. Potential Drug Target For Treating Cocaine Abuse Found
2. NCI Researchers Confirm the Effectiveness of Immunotherapy Approach to Treating Melanoma
3. Opiates Better Than Sedatives For Treating Newborns In Withdrawal
4. Measuring the impact of post-genomics on Mediterranean populations
5. A new study examines how shared pathogens affect host populations
6. New discovery: Molecular variation in one gene affects the growth of natural populations
7. Escapee farmed salmon infiltrate fitter wild populations
8. Researchers make progress in studying genetic traits of India-born populations
9. Commercial fishing causes dangerous fluctuations in fish populations
10. Ongoing collapse of coral reef shark populations
11. Antarctic warming to reduce animals at base of ecosystem, shift some penguin populations southward
Post Your Comments:
(Date:5/23/2013)... when microbial pathogens are growing increasingly resistant to the ... of Wisconsin scientists has synthesized a potent new class ... staph infections. , Writing online in the Journal ... by University of Wisconsin-Madison chemistry Professor Helen Blackwell describes ... of Staphylococcus aureus , a bacterium at the ...
(Date:5/22/2013)... fuel cell powered buses, including a team from ... degradation processes and bus membrane durability. , The ... stressors in the operating cycle of the bus ... the study, led by SFU graduate student Natalia ... at Burnaby-based Ballard Power Systems and funded by ...
(Date:5/22/2013)... Bethesda, Md. (May 22, 2013)The omega 3 fatty acids ... against cardiovascular diseaseso much so that the American Heart ... fish a week, particularly fatty varieties rich in omega ... remains a mystery. In a new study, scientists led ... light on this phenomenon by providing evidence that fish ...
Breaking Biology News(10 mins):University of Wisconsin chemists find new compounds to curb staph infection 2Tests lead to doubling of fuel cell life 2Fish oil may help the heart beat mental stress 2
... thinkers in agriculture, climate change and the environment will ... ways to tackle Africa,s unending cycle of drought and ... another food crisis sweeps across the Sahel region of ... and Mauritania. The conference will take place on ...
... CITY, March 19, 2012Researchers from Huntsman Cancer Institute ... have discovered a method to identify cancer-causing rearrangements ... and inexpensively. A description of the method and ... issue of the EMBO Molecular Medicine journal. ...
... Ill. Food-borne diseases might soon have another warrior to ... at the University of Illinois. The new antibiotic, an analog ... to be a boon to the dairy industry as a ... in milk, a product of bacteria resident in the cow,s ...
Cached Biology News:Beating famine: Sustainable food security through land regeneration in a changing climate 2Beyond the microscope: Identifying specific cancers using molecular analysis 2New antibiotic could make food safer and cows healthier 2New antibiotic could make food safer and cows healthier 3
(Date:5/24/2013)... Oklahoma City, OK (PRWEB) May 24, 2013 ... handful of casualties. And following its ravage, the mayor of ... room bill for new houses, said a report from cnn.com. ... offered the tornado victims complimentary Molderizer and Safe Shield to ... according to the report published on May 22, 2013, caused ...
(Date:5/23/2013)... their baby stopped breathing, his collapsed bronchus blocking the ... Bryan Gionfriddo watched helplessly, just praying that somehow the ... said he had a good chance of not leaving ... 20-month-old son, Kaiba. "At that point, we were desperate. ... run with it." , They found hope at the ...
(Date:5/23/2013)... Yonkers, NY (PRWEB) May 23, 2013 ... GRAPHALLOY® self-lubricating bushings mounted in stainless ... and self-lubricating properties of GRAPHALLOY with the application ... GRAPHALLOY Stainless Steel Pillow Blocks work exceptionally ... other corrosive or hostile liquids such as acids, ...
(Date:5/23/2013)... The maker community is a contemporary group ... focus on learning practical skills while applying them creatively ... their ideas to life via crowdfunding. A subgroup within ... projects using biology. Glowing Plant has worked for months ... glow with bioluminescence genes, and has now pursued crowdfunding ...
Breaking Biology Technology:Mayor of Oklahoma-Tornado-Impaired Town Proposes Storm Shelter Bill, My Cleaning Products Offers Complimentary Molderizer and Safe Shield to Help Victim with Looming Mold 2Baby's life saved with groundbreaking 3-D printed device that restored his breathing 2Baby's life saved with groundbreaking 3-D printed device that restored his breathing 3Graphite Metallizing Now Offers GRAPHALLOY® Stainless Steel Pillow Blocks for Success in Submersible Applications 2Graphite Metallizing Now Offers GRAPHALLOY® Stainless Steel Pillow Blocks for Success in Submersible Applications 3Glowing Plant Releases Maker Kit, Enabling Anyone to Make a Glowing Plant at Home 2
... Without clear leadership and more transparency in federal risk ... a happy accident, rather than a foregone conclusion, says ... Project on Emerging Nanotechnologies (PEN). This sentiment was voiced ... Science & Technology Committees hearing on the National Nanotechnology ...
... Life Sciences,Holdings, Inc. (Nasdaq: ADLS ), today ... Capital Market listing requirements. On April,16, 2008, the ... that it has regained compliance with Nasdaq,Marketplace Rule ... Company,s,common stock has been equal to or in ...
... Md., April 16 The Board of Managers ... Dr. Danong Chen has,been elected as the new ... previously the President and CEO of Tanox Inc., ... Genentech in 2007.,Previously Dr. Chen was Vice-President of ...
Cached Biology Technology:Limited transparency in federal nanotech research may hamper development 2Advanced Life Sciences Regains Compliance With Nasdaq Listing Requirements 2Danong Chen appointed CEO of Theranostics Health 2
anti-dansyl, rabbit IgG fraction *1 mg/mL* Secondary Detection; Anti-Dye and Anti-Hapten Antibodies...
MOUSE ANTI GUINEA PIG T-CELLS (PAN):FITC Immunogen: Guinea pig peritoneal T-cells...
... cloning of BAC (100+kb), fosmid (40kb), and ... stability than any othe BAC vector. On ... yields and easy recombinant DNA purification. Available ... (pSMART VC) vectors for the highest insert ...
... fosmid (40kb), and large plasmid insert (10-20kb) ... BAC vector. On command 20-50 fold copy ... DNA purification. Available with blue-white screening (pEZ ... the highest insert stability. Kits include electrocompetent ...
Biology Products: