Navigation Links
Treating populations infected with HIV and latent TB could speed the emergence of drug-resistant TB

In 2005, 46 regional Ministers of Health in Africa declared that a dramatic rise in tuberculosis (TB) cases was cause for emergency. In some African countries, annual TB case notifications have increased as much as four-fold over the past 15 years. The main culprit? The emergence of HIV. When individuals are infected with both HIV and TB, they are more likely to progress from latent TB infection to active TB.

To combat the problem, the World Health Organization currently recommends that as part of HIV/AIDS programs, patients infected with both HIV and TB be treated with isoniazid, an antimicrobial, as a preventive therapy to reduce the risk that TB will progress from latent infection to active disease. However, researchers from the Harvard School of Public Health (HSPH) and a team of collaborators believe that strategy has flaws. Their findings appear in the advance online edition of the May 2, 2006 issue of Proceedings of the National Academy of Sciences.

The researchers, led by Ted Cohen, doctoral student at HSPH, and senior author Megan Murray, Assistant Professor of Epidemiology, developed a mathematical model to describe the projected impact of isoniazid preventive therapy (IPT) programs on the transmission dynamics of drug-resistant TB in areas where community-wide preventive therapy may be used as a strategy to control TB. They concluded that the implementation of IPT targeted to people co-infected with HIV and TB may also have the perverse effect of speeding the emergence of drug-resistant TB.

"We're not saying isoniazid preventive therapy policies are ill-advised," said Cohen. "But we think they need to be coupled with an understanding that large-scale IPT programs should be ready to diagnose and treat individuals with drug-resistant TB as part of the programs."


'"/>

Source:Harvard School of Public Health


Page: 1

Related biology news :

1. Potential Drug Target For Treating Cocaine Abuse Found
2. NCI Researchers Confirm the Effectiveness of Immunotherapy Approach to Treating Melanoma
3. Opiates Better Than Sedatives For Treating Newborns In Withdrawal
4. Measuring the impact of post-genomics on Mediterranean populations
5. A new study examines how shared pathogens affect host populations
6. New discovery: Molecular variation in one gene affects the growth of natural populations
7. Escapee farmed salmon infiltrate fitter wild populations
8. Researchers make progress in studying genetic traits of India-born populations
9. Commercial fishing causes dangerous fluctuations in fish populations
10. Ongoing collapse of coral reef shark populations
11. Antarctic warming to reduce animals at base of ecosystem, shift some penguin populations southward
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/17/2017)... MELBOURNE, Florida , April 17, 2017 ... security technology company, announces the filing of its 2016 Annual Report ... Securities and Exchange Commission. ... Report on Form 10-K is available in the Investor Relations section ... well as on the SEC,s website at http://www.sec.gov . ...
(Date:4/11/2017)... BEACH GARDENS, Fla. , April 11, 2017 ... identity management and secure authentication solutions, today announced ... contract by Intelligence Advanced Research Projects Activity (IARPA) ... for IARPA,s Thor program. "Innovation has ... onset and IARPA,s Thor program will allow us ...
(Date:4/11/2017)... , April 11, 2017 NXT-ID, Inc. ... technology company, announces the appointment of independent Directors Mr. ... to its Board of Directors, furthering the company,s corporate governance ... Gino ... we look forward to their guidance and benefiting from their ...
Breaking Biology News(10 mins):
(Date:8/15/2017)... ... August 15, 2017 , ... Any expert in stem cell ... these disciplines for more than half a century. Despite their essential roles in ... is widely known that molecular tags developed for this purpose also tag other, more ...
(Date:8/15/2017)... Linda, Ca (PRWEB) , ... August 15, 2017 ... ... coffee production and is threatened by various biotic and abiotic factors. During this ... complex evolutionary history of coffee, as well as gain a better understanding of ...
(Date:8/14/2017)... ... August 14, 2017 , ... Opal Kelly, ... USB or PCI Express, announced the release of SYZYGY™, a new open standard ... the need for a compact, low cost, low pin-count, high-performance connectivity solution between ...
(Date:8/11/2017)... Texas (PRWEB) , ... August 11, 2017 , ... A ... rebranding campaign this month that will incorporate important key elements including a new digital ... the community that has supported them, Bill Miller has partnered with the South Texas ...
Breaking Biology Technology: