Navigation Links
Tramiprosate (Alzhemed? preclinical results published in Neurobiology of Aging

vely.
  • Tramiprosate (Alzhemed? crosses the blood-brain-barrier to exert its activity with low toxicity in various animal species that were tested.

    • The presence of amyloid in the brain is one of the major histopathological characteristics of AD. The amyloid cascade hypothesis proposes that certain forms of Aβ peptide are toxic and causally related to the severity of AD. The Aβ-peptide is one of the most promising targets for the development of AD therapies.

    "This scientific paper highlights the potential benefits of Alzhemed?" said Dr. Andreas Orfanos, Neurochem's Executive Vice President, Strategic Planning and Scientific Affairs. "These preclinical results indicate that AlzhemedTM binds preferentially to soluble amyloid β peptide, interferes with the amyloid cascade and reduces the associated toxicity. Accordingly, this product candidate is shown to impede key detrimental events normally associated with Alzheimer's disease and which are believed to lead to severe consequences in the brain of the affected individuals."

    About tramiprosate (Alzhemed?
    Tramiprosate (Alzhemed? is a small, orally-administered molecule known as an amyloid β antagonist, designed to cross the blood-brain-barrier, bind to soluble Aβ peptide and interfere with the amyloid cascade, thereby leading to the prevention or inhibition of amyloid deposition and the toxic effects of Aβ peptide in the brain.

    About the Phase III Clinical Trials for tramiprosate (Alzhemed?
    Neurochem is currently conducting a multi-center, randomized, double-blind, placebo-controlled and parallel-designed, 18-month Phase III clinical trial in 1,052 mild-to-moderate AD patients which is being carried out at close to 70 clinical sites across the United States and Canada. To date, 600 patients have already completed 12 months on study medication and the trial is scheduled to be completed by January 2007. All patients who complete the
    '"/>

    Source:Neurochem, Inc.


    Page: 1 2 3

    Related biology news :

    1. Fatty spheres loaded with siRNA shrink ovarian cancer tumors in preclinical trial
    2. Dual gene therapy suppresses lung cancer in preclinical test
    3. Gene vaccine for Alzheimers disease shows promising results
    4. Roche clinical trial registry and results database launched
    5. Diabetic nerve therapy shows striking results
    6. Neurologix announces positive results of gene therapy clinical trial in Parkinsons disease
    7. New results validating Pall prion reduction filter disclosed at ISBT Congress
    8. Combination therapy shows promising results in patients with advanced lung cancer
    9. Vaccine for brain tumors shows promising results
    10. Artificial cornea offers better results for infants, some blind patients
    11. Encouraging results in pancreatic cancer research
    Post Your Comments:
    (Date:5/16/2013)... decades, scientists have used ancient shorelines to predict the stability ... of a high shoreline from three million years ago, for ... were thought to be evidence of a high sea ... assumption has led many scientists to think that if the ... may do just the same in our modern, progressively warming ...
    (Date:5/16/2013)... cellular layer lining the body,s blood vessels, is ... in thickness, this super-tenuous structure routinely withstands blood ... create a unique and highly dynamic barrier that ... the body,s circulatory system. , It,s also extremely ... physically breached to enable immune cells to ...
    (Date:5/16/2013)... S.C. , May 16, 2013 ... in combination with a custom thin film transistor ... highest forensic quality roll image in the smallest ... today. Sherlock, an Appendix F Mobile ID FAP ... a 95% reduction in size and weight when ...
    Breaking Biology News(10 mins):World's biggest ice sheets likely more stable than previously believed 2Endothelium, heal thyself 2Endothelium, heal thyself 3Endothelium, heal thyself 4
    ... flu interventions must be imposed quickly, if they are ... journal BMC Public Health have shown that ... within the home should reduce infection, but only if ... maintained for a relatively long period. Professor George ...
    ... that appears not only to be central to the ... a role in muting the high from methamphetamine and ... known as organic cation transporter 3 or oct3, fills ... damage that causes symptoms like tremor, stiffness, slowness of ...
    ... -- Arizona State University will be home to a new ... in conjunction with a speech delivered by President Barack Obama. ... will pursue advanced scientific research on solar energy conversion based ... capture sunlight and convert it to useful energy. All 46 ...
    Cached Biology News:Social separation stops flu spread, but must be started soon 2Brain protein central to both Parkinson's, drug addiction identified 2Brain protein central to both Parkinson's, drug addiction identified 3Brain protein central to both Parkinson's, drug addiction identified 4DOE funds bio-inspired solar fuel center at Arizona State 2DOE funds bio-inspired solar fuel center at Arizona State 3DOE funds bio-inspired solar fuel center at Arizona State 4
    (Date:5/17/2013)... Mechanicsburg, PA (PRWEB) May 17, 2013 ... with ramp/soak capabilities. The 5R6-900 temperature controller has many ... can be plugged into the wall as a self-contained ... power supply. This distinctive detail makes the device unique, ... , The controller can also be used universally, which ...
    (Date:5/17/2013)... N.C., USA (PRWEB) May 17, 2013 ...     Green Globes Certified for sustainability ,     New facility ... pressures , Syngenta unveiled its ... today at the company’s RTP Innovation Center. The first ... company researchers to simulate any agricultural climate and precisely ...
    (Date:5/17/2013)... , May 17, 2013  Insero Health, Inc., ... needs in epilepsy and related neurological disorders, is today ... its lead compound INS001 in patients with drug-resistant epilepsy.  ... and Device Trials (AED) Xll meeting by Dr. ... and Chairman of Insero,s Scientific Advisory Board.  In this ...
    (Date:5/17/2013)... IAC Industries wants to share with you the ... to set up and furnish a research lab knowing that ... a year’s time. How does a company make choices in ... What is efficient and cost-effective? , The solution was ... The planners at DisperSol determined that the concept of modular ...
    Breaking Biology Technology:New Temperature Control Products Announced by Oven Industries Inc. 2Syngenta Opens Unique $72 Million Advanced Crop Lab 2Syngenta Opens Unique $72 Million Advanced Crop Lab 3Insero Health Reports Positive Data on Phase I Trial of Novel Therapy for Drug-resistant Epilepsy 2New Downloadable Success Story: “How To Outfit a Dynamic Lab in Flux” 2
    ... ALTO, Calif., Sept. 27 CV Therapeutics,Inc. (Nasdaq: ... has submitted a,supplemental new drug application (sNDA) to ... expansion to the approved product labeling,for Ranexa(R) (ranolazine ... new indication for first line treatment,of chronic angina ...
    ... 27 Cattle producers,soon will find that the latest ... safe are as close at hand as their desktop ... is leading to the creation of,software that will help ... production medicine at K-State,s College of,Veterinary Medicine, is involved ...
    ... of strategic plan, WATERTOWN, Mass., Sept. 27 ... Boston Biomedical Research Institute, an independent,not-for- profit biomedical ... new scientists, a 23% increase in its scientific ... the fruits of a three-year,strategic planning process designed ...
    Cached Biology Technology:CV Therapeutics Submits Supplemental New Drug Application for Ranexa(R) (ranolazine extended-release tablets) 2K-State Research Leading to Software to Help Nation's Cattle Producers Identify Biosecurity Risks, Evaluate Impact of Cow-Calf Diseases Online 2New Scientists Boost Disease-based Research at Boston Biomedical Research Institute 2New Scientists Boost Disease-based Research at Boston Biomedical Research Institute 3
    ... assay for mitochondrial membrane potential detection ... are detected by carboxyfluorescein (FAM)-labelled fluoromethylketone ... non-cytotoxic and bind covalently to the ... the same time the mitochondrial membrane ...
    ... cells were cultured in DMEM and harvested at ... to keep the antigens in their native forms, ... are arrayed on a 12-well (5 mm) adhesive ... to enhance cellular attachment and to minimize background ...
    ... CopyControl™ vector can be induced prior to ... provide the stability of single-copy BACs with ... other cloning vectors. The kits provide the ... insert size screening system) necessary to create ...
    Screening assay to detect the Listeria monocytogenes in food samples by,DNA amplification and molecular hybridization on a microtiter plate....
    Biology Products: