Navigation Links
Toxic molecule may cause most common type of muscular dystrophy

Doctors at the University of Virginia Health System have shown for the first time that getting rid of poisonous RNA (ribonucleic acid) in muscle cells can reverse myotonic dystrophy, the most common type of muscular dystrophy in adults.

About 40,000 people in the United States have myotonic muscular dystrophy (MMD). The disease can cause a slow, progressive wasting of the muscles, irregular heartbeat, cataracts and insulin resistance. Many people don't know they have MMD until their teens or twenties.

To prove the theory that toxic RNA is involved in myotonic muscular dystrophy, a research team led by Dr. Mani Mahadevan, a UVa pathologist, duplicated the disease in mice. "We showed in our mouse model that when you make this poisonous RNA the mice get various aspects of myotonic dystrophy," Mahadevan said. "Then, when you take away the toxic RNA, the mice get back to normal."

Mahadevan hopes the research might lead to new therapies for MMD in the next few years. "If we develop a therapy to silence the expression of the toxic RNA molecule, that would be a viable approach to treat people with myotonic muscular dystrophy," he said. Mahadevan's research in published in the September 2006 issue of Nature Genetics and can be found online at: http://www.nature.com/ng/index.html

Making RNA is the second step in the conversion of DNA into proteins that determine the function of the body's cells. Myotonic muscular dystrophy is the first example of a disease caused by toxic RNA.

In 1992, Mahadevan discovered the gene mutation that causes myotonic muscular dystrophy (type 1) as part of a research group in Canada. The mutation is an increased number of CTG repeats in a gene called DMPK. Everyone with myotonic muscular dystrophy has that mutation on chromosome 19, which is now part of a genetic, diagnostic test for myotonic dystrophy.

In their latest research, Mahadevan and c
'"/>

Source:University of Virginia Health System


Page: 1 2

Related biology news :

1. Solution to Pollution: New Bacteria Eats Toxic Waste
2. Duke Chemists Isolating Individual Molecules Of Toxic Protein In Alzheimers, Parkinsons Disease
3. Same-Sex Mating Discovered in a Toxic Fungus
4. Toxic flood lifts lid on common urban pollution problem
5. Chemists create Superbowl molecule; May lead to better health
6. Key molecule in plant photo-protection identified
7. Inflammatory molecules released by pollen trigger allergies
8. Researchers discover molecule that causes secondary stroke
9. Yale researchers identify molecule for detecting parasitic infection in humans
10. Scientists identify molecule that regulates well-known tumor suppressor
11. Medical molecules designed to respond to visible light that can penetrate tissue
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Toxic molecule may cause most common type muscular dystrophy

(Date:4/6/2015)... Conn. , Apr. 6, 2015 NXT-ID, ... "Company"), a biometric authentication company focused on the ... has filed provisional patent 62/143028 for ... COMMUNICATIONS AND ENERGY TRANSFER  NXT-ID introduces a ... payments. This patent surrounds the use of miniature ...
(Date:4/2/2015)... GOTHENBURG, Sweden , April 2, 2015 ... for its touch fingerprint sensor FPC1025 from the distributor ... Deliveries will commence during Q2 2015 although the major ... 2015. The sensors will be used by smartphone manufacturers ... of 110 MSEK is included in the communicated revenue ...
(Date:3/31/2015)... NEW YORK , March 31, 2015   ... announced the launch of the Post-Surgical Pain Management TRACKER, ... data products tracking usage trends in the medical device ... monthly access to data including treatment volumes, market share, ... manage the pain associated with joint surgery. ...
Breaking Biology News(10 mins):NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 2NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 3NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 4Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 110 Million 2Guidepoint Launches Post-Surgical Pain Management TRACKER 2Guidepoint Launches Post-Surgical Pain Management TRACKER 3
... the protein responsible for transporting nutrients to the eye ... age-related macular degeneration, a leading cause of vision loss ... the process by which compounds called lutein and zeaxanthin ... have suggested that high concentrations of these two dietary ...
... 28, 2008The 2008 American Society for Microbiology ... Award is presented to Vctor de Lorenzo, ... of the Spanish Research Council, Cantoblanco-Madrid, Spain. ... has exhibited exemplary leadership in the international ...
... to be physically active. The key to being active is ... exercise in maintaining fitness has created the idea that individuals ... if the inclination to engage in physical activity is itself ... suggest that the inclination to exercise may be strongly affected ...
Cached Biology News:Protein transports nutrients believed to protect against eye disease 2Protein transports nutrients believed to protect against eye disease 3American Society for Microbiology honors Victor de Lorenzo 2Can you be born a couch potato? 2Can you be born a couch potato? 3
(Date:5/5/2015)... SAN DIEGO , May 5, 2015 /PRNewswire/ ... today announced that David R. Parkinson , ... (NEA), has been appointed to the board of ... twenty years of experience in oncology clinical development, ... that resulted in global approvals of the cancer ...
(Date:5/5/2015)... 05, 2015 Synedgen Inc. is pleased ... Regulatory Affairs Manager. , Dr. Nguyen brings to Synedgen ... for the company as it moves forward in the ... the next two years. Dr. Nguyen will lead the ... regulatory key documents that must be completed in order ...
(Date:5/4/2015)... Medical Research Inc., a Montreal based Contract ... Max Neeman International (MNI), with head office in New ... Bangalore , Chennai and ... office is located North Carolina, USA . ... investment transaction into JSS with Capital Croissance PME (CCPME), a joint ...
(Date:5/4/2015)... , May 4, 2015  Traverse Biosciences announced ... research and development agreement (CRADA) with Aratana Therapeutics ... development of TRB-N0224 for the treatment and control ... and cats.  Traverse Biosciences has also granted Aratana ... treatment and control of periodontal disease in companion ...
Breaking Biology Technology:Tocagen Appoints David R. Parkinson, M.D., to the Board of Directors 2Tocagen Appoints David R. Parkinson, M.D., to the Board of Directors 3Tocagen Appoints David R. Parkinson, M.D., to the Board of Directors 4Synedgen Announces the Appointment of Regulatory Affairs Manager 2JSS Medical Canada widens its global presence across Asia/Pacific region 2JSS Medical Canada widens its global presence across Asia/Pacific region 3JSS Medical Canada widens its global presence across Asia/Pacific region 4Traverse Biosciences Executes Agreement with Aratana Therapeutics to Advance Development of TRB-N0224 for the Treatment and Control of Periodontal Disease in Pets 2Traverse Biosciences Executes Agreement with Aratana Therapeutics to Advance Development of TRB-N0224 for the Treatment and Control of Periodontal Disease in Pets 3Traverse Biosciences Executes Agreement with Aratana Therapeutics to Advance Development of TRB-N0224 for the Treatment and Control of Periodontal Disease in Pets 4
... N.J., Jan. 3 Pharmos Corporation,(Nasdaq: PARS ... initial closing of,a private placement of its 10% ... the Company issued $4,000,000 principal amount of the,Debentures, ... same amount., The purchasers consisted of certain ...
... RUTHERFORD, N.J., Jan. 3 Cambrex,Corporation (NYSE: ... A. Mack,Chairman, President and Chief Executive Officer, will ... Healthcare Conference on January 8, 2008 at,9:00 a.m. ... California., (Logo: http://www.newscom.com/cgi-bin/prnh/20000613/CAMBREXLOGO ), ...
... Holdings, Inc., a fully,integrated critical care biopharmaceutical company, ... will present at the 26th Annual JPMorgan,Healthcare Conference ... PST. The,conference will be held January 7-10 at ... About Ikaria Holdings, Inc., Ikaria Holdings, Inc. ...
Cached Biology Technology:Pharmos Corporation Completes Initial Closing of Private Placement 2
... The Dodeca silver stain kits ... staining devices including Bio-Rad Dodeca stainers. ... nanogram quantities of proteins in polyacrylamide ... The kit includes sensitizer concentrate, silver ...
... and effectively in tubes and 96 well plates. ... tube, one and a half spin DNA cleanup ... or concentrate any type of double stranded DNA, ... or dNTPs (labelled or unlabelled). It is therefore ...
PTC-100 cycler with gold/silver block with Hot Bonnet heated lid, holds one 96-well V-plate or96x0.2ml tubes...
... RNA (bluish-purple), DNA (blue), proteins (red) and acid polysaccharides ... Cation traces: Ca ≤ 10 mg/kg Cd ≤ 5 ... Cu ≤ 5 mg/kg Fe ≤ 5 mg/kg K ... 5 mg/kg Na ≤ 50 mg/kg Ni ≤ 5 ...
Biology Products: