Navigation Links
Touching Molecules With Your Bare Hands

For a virus to survive, it must elude the ever vigilant immune sentinels of its host. A latent virus can escape immune detection if it resides in nondividing cells and doesn’t produce any proteins. No viral proteins means no red flags for immune cells. If the virus targets one of the many cell types that rarely divide, it’s relatively safe while latent. But some viruses, like the gamma-herpesvirus, infect B cells of the immune system, which occasionally divide. The gamma-herpesvirus genome persists as circular pieces of DNA called episomes. When an infected B cell divides, the latent gamma-herpes virus episome must replicate and segregate into daughter cells along with the cell’s genome. Viral replication and segregation requires the services of a protein called the episome maintenance protein—a potentially recognizable target for immune cells.

Gamma-herpesviruses, including Epstein-Barr virus (EBV) and Kaposi’s sarcoma–associated herpesvirus (KSHV), can induce uncontrolled lymphocyte (immune cell) proliferation and result in lymphoma, Hodgkin’s disease, and Kaposi’s sarcoma. These diseases arise from the persistent latent infections that take hold after initial infections are controlled by immune defenses. The episome maintenance protein produced by EBV, called EBNA-1, harbors an amino acid element in its epitope—the region that binds to a T cell and triggers an immune response—that helps the viral protein evade the killer T cells that could destroy it. Lab studies show that the amino acid element limits EBNA-1’s interaction with T cells by inhibiting synthesis and, to a lesser degree, degradation of the protein. How this evasive action works or helps the virus in a living organism is not entirely clear. But if T cells aren’t presented with bits of viral protein, they have no way of knowing the virus is present.

In a new study, Neil Bennett, Janet May, and Philip Stevenson explore this question by studying virus–host interactions in mice infected wit
'"/>

Source:


Page: 1 2 3

Related biology news :

1. DNA Molecules Used To Assemble Nanoparticles
2. Duke Chemists Isolating Individual Molecules Of Toxic Protein In Alzheimers, Parkinsons Disease
3. Team Invents Device For Weighing Individual Molecules
4. Molecules in blood foretell development of preeclampsia
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Touching Molecules With Your Bare Hands

(Date:3/23/2015)... Inc. (NASDAQ: NXTD ) ("NXT-ID" or the "Company"), a ... announces its biometric payment technology, the Wocket® smart wallet, will ... 30 th . The new 30 ... markets. Gino Pereira , ... ad campaign following the recent initial shipment of Wocket smart ...
(Date:3/19/2015)...  NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or ... mobile commerce market, announces its biometric payment technology, the Wocket® ... this week on Washington DC,s Fox ... segment "The Next Great Thing", host Laura Evans ... and ,a really big breakthrough in mobile payment.,  ...
(Date:3/16/2015)... , March 16, 2015 ... Systems GmbH will present groundbreaking innovations in biometric ... Hanover, Germany .      (Photo: ... latest biometric innovation is well at the forefront: ... generation e-gate made in Germany ...
Breaking Biology News(10 mins):NXT-ID's Wocket Smart Wallet to Launch New CNBC Regional TV Ad Campaign 2NXT-ID's Wocket Smart Wallet to Launch New CNBC Regional TV Ad Campaign 3NXT-ID's Wocket Smart Wallet Featured on Fox News Segment, "The Next Great Thing" 2NXT-ID's Wocket Smart Wallet Featured on Fox News Segment, "The Next Great Thing" 3DERMALOG Presents its Latest Biometric Innovations at the Hannover CeBIT Exhibition, 16 - 20 March 2015 2DERMALOG Presents its Latest Biometric Innovations at the Hannover CeBIT Exhibition, 16 - 20 March 2015 3
... other diet related health problems received a 4 Million boost ... projects, taking place in universities and research institutes across the ... Councils and 15 companies. This means the research being funded ... society but in a way that the food industry will ...
... You might watch your daily calorie intake or glance over ... same for your pet? Dr. Susan Nelson, a veterinarian ... said there are several guidelines to follow when feeding your ... like human food packages, many cat and dog food packages ...
... Antonio Breast Cancer Symposium will honor two leading breast cancer ... in San Antonio. The awards will be given ... the Cancer Therapy and Research Center at The University of ... the meeting for nearly 9,000 attendees. Robert Weinberg, ...
Cached Biology News:Public sector and industry unite to attack obesity and heart disease 2Owners should count calories for obese pets, consider several factors for good health 2Owners should count calories for obese pets, consider several factors for good health 3American Association for Cancer Research to honor leading researchers at breast cancer symposium 2
(Date:3/31/2015)... Pittsburgh, PA (PRWEB) March 31, 2015 ... Chemistry and Applied Spectroscopy, ended on March 12, in ... estimated at $21 million as estimated by the New ... together more than 14,200 conferees and exhibitor personnel. ... 36% of the conferee number. For the third year, ...
(Date:3/31/2015)... YARDLEY, Pa. , March 31, 2015 /PRNewswire/ ... capabilities by integrating Mapi,s Medical Affairs and global ... Pharmacovigilance from a previously announced acquisition . ... operations are conducted by a global team ... professionals that have decades of experience in navigating ...
(Date:3/31/2015)... March 31, 2015  University of Illinois, ... will deliver the plenary session address on Monday, May ... Symposium (IMS) , kicking off a week of more ... the intersection of RF and microwave technologies with health. ... Radios, Sensors and Circuits for the Skin," will focus ...
(Date:3/31/2015)... Cleveland, OH (PRWEB) March 31, 2015 ... from its licensor, SDG, Inc., that a United States ... for liver-targeted insulin therapy. , Entitled “Lipid ... patent covers composition of matter claims related to the ... a system for enabling injected insulin to more effectively ...
Breaking Biology Technology:Pittcon 2015 Hits the Big Easy in a Big Way 2Pittcon 2015 Hits the Big Easy in a Big Way 3Pittcon 2015 Hits the Big Easy in a Big Way 4Mapi expands Pharmacovigilance and Risk Management capabilities 2Mapi expands Pharmacovigilance and Risk Management capabilities 3Health and Engineering Converge at the 2015 International Microwave Symposium 2Health and Engineering Converge at the 2015 International Microwave Symposium 3Diasome Pharmaceuticals, Inc. Announces Notice of Allowance from US PTO for Liver Targeting System for Insulin 2
... at the Georgia Institute of Technology have developed a ... a key ingredient found in many explosives. ... on paper or paper-like material using standard inkjet technology, ... to the presence of explosives, such as improvised explosive ...
... release is available in German . , ... a car engine is completely normal for a micro engine. ... of the smallest particles, which interfere with its running. Researchers ... Institute for Intelligent Systems have now observed this with a ...
...  Kensey Nash Corporation (Nasdaq: KNSY ) today ... (Nasdaq: SPNC ) that they reached a ... product lines purchased from Kensey Nash in May 2008. ... payable to Kensey Nash.  As previously disclosed, the Company ...
Cached Biology Technology:Low-cost paper-based wireless sensor could help detect explosive devices 2Low-cost paper-based wireless sensor could help detect explosive devices 3Low-cost paper-based wireless sensor could help detect explosive devices 4The world's smallest steam engine 2The world's smallest steam engine 3
... For the ultimate in utility and flexibility ... meet the needs of the researcher. They ... dimensions or as sheet material that can ... These isolators are autoclavable and non-cytotoxic and ...
... mycobacteria found in Complete Freund's Adjuvant so it ... Freund's Adjuvant is used for the ... produce water-in-oil emulsions of immunogens. Antigens ... responses which can be attributed to the slow ...
2,4-Dinitrophenyl hapten is conjugated to Keyhole Limpet (KLH) protein through lysine....
PGF1α-d4 contains 4 deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of PGF1α by GC- or LC-mass spectrometry....
Biology Products: