Navigation Links
Topical treatment shown to inhibit HIV and herpes simplex virus infection

Mount Sinai School of Medicine researchers demonstrated that a gel applied in the vagina provides protection from both the human immunodeficiency virus (HIV) and the herpes simplex Virus. The study, presented at the 12th Conference on Retroviruses and Opportunistic Infections, is the first to show that a gel can retain anti-viral activity within the human vagina.

The study, which was funded by the National Institutes of Health (NIH) investigated the efficacy of PRO 2000, a topical microbicide under development by Indevus Pharmaceuticals, Inc.

"There is an urgent need for the development of safe and effective vaginal microbicides," Marla Keller, M.D., Assistant Professor of Medicine at the Mount Sinai School of Medicine and the researcher who presented the data. "While condoms offer protection against sexually transmitted infections, their effectiveness is limited because they require partner initiation or consent."

According to the United Nations' 2004 report on the global AIDS epidemic, an estimated 40 million people worldwide are living with HIV, and women account for nearly half of those infected. As stated by the World Health Organization, unprotected sex is the predominant mode of HIV transmission, and genital herpes plays a major role in the sexual spread of HIV.

The researchers conducted a prospective, randomized, double blind, placebo-controlled study among 20 HIV-infected women to assess the antiviral activity of PRO 2000 in cervicovaginal lavage (CVL) fluid collected before and one hour after administration of a single intravaginal dose of PRO 2000 gel or a matched placebo gel. CVL specimens were tested for their ability to prevent HIV and HSV infection of susceptible human cells in culture. Levels of inflammatory cytokines were also measured as markers of acute inflammation.

Analyses showed that CVL obtained after the application of PRO 2000 gel reduced both HIV and HSV infectivity by at least 1000-fold compared to C
'"/>

Source:Mount Sinai Hospital / Mount Sinai School of Medicine


Page: 1 2

Related biology news :

1. Protein discovery could unlock the secret to better TB treatment
2. Weizmann Institute scientists develop a new approach for directing treatment to metastasized prostate cancer in the bones.
3. Researchers add new tool to tumor-treatment arsenal
4. Potential treatments for neurofibromatosis
5. Nanoparticles offer new hope for detection and treatment
6. Technique may allow cancer patients to freeze eggs, preserving fertility before starting treatment
7. PET/CT can identify new cancer lesions at early stage, allowing for prompt treatment
8. New understanding of DNA repair may pave way to cancer treatments
9. Multiple-drug resistant gene expression pattern predicts treatment outcome for pediatric leukemia
10. Newer imaging techniques may lead to over-treatment
11. Asymptomatic HIV babies could use earlier treatment
Post Your Comments:
(Date:4/14/2015)... OXFORD, Conn. , April 14, 2015 ... "Company"), a biometric authentication company focused on the growing ... has been nominated for the 2015 New York Design ... The Design100, New York City Design Awards are ... are based on over 2,500 ratings from the marketplace, ...
(Date:4/8/2015)... 8, 2015  Infinisource, a leading provider of SaaS-based ... Morpho, a leading supplier of biometric identification and ... market,s most advanced biometrically-enabled time clock, the companies ... clock is setting a bold, new standard for ... the small and mid-size employer. When connected to ...
(Date:4/2/2015)... GOTHENBURG, Sweden , April 2, 2015 ... for its touch fingerprint sensor FPC1025 from the distributor ... Deliveries will commence during Q2 2015 although the major ... 2015. The sensors will be used by smartphone manufacturers ... of 110 MSEK is included in the communicated revenue ...
Breaking Biology News(10 mins):NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 2NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 3iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 3Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 110 Million 2
... of Anthropology Jeffrey H. Schwartz and University of Salerno ... the New Anatomist journal, shows that the emerging understanding ... of evolution, originally explained in his seminal work, Sudden ... Wiley & Sons, 2000). , In that book, Schwartz ...
... simplest bacteria need almost twice as many genes to survive ... Nature (30 March 2006). , Bacteria are some of the ... trying to identify the smallest collection of genes ?or minimal ... scientists have done this by removing, or 'knocking out', a ...
... the 3-billion-base human genome play a vital role in ... the Wellcome Trust Sanger Institute and the Cambridge University's ... report in PLoS Genetics their detailed maps of differences ... unchanged in recent human history. , The Major ...
Cached Biology News:Pitt professor's theory of evolution gets boost from cell research 2Pitt professor's theory of evolution gets boost from cell research 3Minimal genome should be twice the size, study shows 2Minimal genome should be twice the size, study shows 3Researchers map of genetic variations implicated in disease 2Researchers map of genetic variations implicated in disease 3
(Date:4/21/2015)... 21, 2015 Research and Markets ... the "Complete 2015-16 Induced Pluripotent Stem Cell ... Stem cell research and experimentation have ... as stem cells have the unique ability to ... nature allows them to differentiate into a wide ...
(Date:4/21/2015)... NEW YORK , April 21, 2015 ... announced today that its abstract submission has been accepted ... Diabetes Association,s (ADA) annual meeting taking place on June 5-6, ... According to the American Diabetes Association, the ... 2014 was $245 billion. As a result of increased ...
(Date:4/21/2015)... Calif. , April 21, 2015 /PRNewswire/ ... provider of advanced cryogenic logistics solutions for ... immunotherapies, stem cells, cell lines, clinical research ... announced that Dr. Mark W. Sawicki ... the 3rd Annual BioLogistics Summit in ...
(Date:4/21/2015)... SPRING, Md. and RESEARCH TRIANGLE ... United Therapeutics Corporation (NASDAQ: UTHR ) announced today ... results before market open on Tuesday, April 28, 2015. ... on Tuesday, April 28, 2015, at 9:00 a.m. Eastern ... international callers dialing 1-970-315-0533.  A rebroadcast of the teleconference ...
Breaking Biology Technology:Global Complete 2015-16 Induced Pluripotent Stem Cell (iPSC) Industry Report 2AbilTo To Present at the 2015 American Diabetes Association Annual Meeting on Remote Delivery of Behavioral Change Therapy 2AbilTo To Present at the 2015 American Diabetes Association Annual Meeting on Remote Delivery of Behavioral Change Therapy 3Cryoport to Present at the 3rd Annual BioLogistics Summit in San Francisco, CA 2Cryoport to Present at the 3rd Annual BioLogistics Summit in San Francisco, CA 3
... 33% more data than the previous product generation. ... of the 1.5 GB Cornice Storage Element (SE), ... Element. These storage devices are used in consumer ... amounts of reliable, inexpensive storage in a small space. ...
... of Silicon Valley has joined the doom of Y2K in ... to revisit the importance of technology to Northeast Wisconsin. After ... the so-called new economy, one fact remains: More money must ... , ,In this post-technology age, the only thing about technology ...
... Brookfield, Wis. - Fiserv Health, an operating group of ... Avidyn Health, a care management company targeting the self-funded ... provides independent health plan management, claims processing and administration ... With the addition of Avidyn Health, Fiserv Health now ...
Cached Biology Technology:With Larger Storage Capacity Comes Smaller Devices 2Look at the New Economy, Just Like the Old Economy 2Fiserv Launches Avidyn Health to Target Healthcare Costs 2
... are rigid macroporous hydrophilic media. The rigid ... moderate pressures, while the macroporous beads enhance ... matrix reduces nonspecific binding. Macro-Prep High Q ... with very high flow rates and resolution. ...
... --- a cocktail of 3 siRNAs specifically ... our most popular product. The siTrio reagent ... of your target gene when used under ... and confirmation of optimal transfection with one ...
... collection of phage display libraries, human ... and mouse tissues. All cDNA libraries ... size of cDNA inserts has been ... 1000bp by gel electrophoresis of DNA ...
... The IDS 25-Hydroxy Vitamin D kit ... quantitative determination of 25-hydroxyvitamin D (25-OH ... human serum or plasma. Our patented ... of solvent precipitation and centrifugation and ...
Biology Products: