Navigation Links
Tool developed to silence genes in specific tissues using RNAi

ols the formation of adherens junctions, or the cell-to-cell contacts between nurse cells and the germ cells that ultimately become sperm.

Using RNAi to silence WT1, therefore, led to the discovery that WT1 is the first transcription factor shown to regulate the formations of these junctions, Wilkinson says. "It is a transcription factor that dictates both the formation of the testes in the embryo, and the function of the testes after birth."

Researchers worldwide have been trying to harness the power of RNAi since it was discovered in 1998. RNAi rocked the world of science because of the vast implications this natural cellular control system potentially offered medicine.

RNAi is used by cells in many life forms to identify viral RNA, which often enters a cell as a double strand. The organism's own RNA, however, leaves the nucleus of cells (where it was produced by DNA) as a single strand, to be decoded by ribosomes into the proteins that perform all the work of the cell. RNAi, therefore, recognizes the double strand of viral RNA as different, and sets in motion cell machinery that destroys the invading RNA. This involves cutting up the double-stranded RNA, separating it into single strands, and destroying other single-stranded RNA molecules that are complementary to those small RNA segments.

Scientists quickly realized that if they could produce a double-stranded RNA that mimics the RNA produced by a gene they wish to silence, RNAi would do the job for them. Producing the decoy "small RNAs" that trigger RNAi has become a fairly simple process, Wilkinson says, but the difficulty has been to use these matches only in specific tissues, and to figure out a way to make this "treatment" last. The work by the M. D. Anderson team has come up with a solution that solves both problems.

The technique they developed involves use of two different "modules" that can be swapped in and out of the backbone of a vector. One is a small stem lo
'"/>

Source:University of Texas M. D. Anderson Cancer Center


Page: 1 2 3

Related biology news :

1. Robot-based system developed at Carnegie Mellon detects life in Chiles Atacama desert
2. Disease progression model of pancreatic cancer developed by Penn researchers
3. New HIV drug candidate developed in Sweden
4. Anthrax test, developed by army and CDC, receives FDA approval
5. Scientists discover that three molecules may be developed into new Alzheimers drugs
6. Portable cocaine sensor developed at UC Santa Barbara
7. Carbon nanotubes that detect disease-causing mutations developed by Pitt researcher
8. Potential vaccine developed for deadly leishmaniasis disease
9. New strategy developed to combat West Nile Virus
10. Faster, more accurate tuberculosis test developed
11. Resistance to anti-HIV drugs in Uganda developed due to drug supply problems
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Tool developed silence genes specific tissues using RNAi

(Date:6/15/2015)... , Jun. 15, 2015 NXT-ID, Inc. (NASDAQ: NXTD ... on the growing mobile commerce market, announces that its leading ... to media at Digital Experience! @ NYC June 18th. ... of the latest innovation in technology to over 300 of ... held at the Metropolitan Pavilion in New York ...
(Date:6/10/2015)... , June 10, 2015 ... "3D Sensor Market by Technology (Ultrasound, TOF, Structured ... (consumer Electronics, Entertainment, Automotive) and by Geography - ... by MarketsandMarkets, the market is expected to reach ... of 25.51% between 2015 and 2020. ...
(Date:6/8/2015)... , June 8, 2015  Trovagene, Inc. (NASDAQ: TROV ... clinical data featuring its Precision Cancer Monitoring SM platform ... Liquid Biopsies conference in San Diego, CA ... Precision Medicine Series: Integrating Clinical Genomics and Cancer Therapy ... June 13-16. "We continue to advance our ...
Breaking Biology News(10 mins):Wocket Smart Wallet Exhibiting at Pepcom Digital Experience! @ NYC June 18th 2Wocket Smart Wallet Exhibiting at Pepcom Digital Experience! @ NYC June 18th 33D Sensor Market Worth $3,319.71 Million by 2020 23D Sensor Market Worth $3,319.71 Million by 2020 33D Sensor Market Worth $3,319.71 Million by 2020 4Clinical Data Featuring Trovagene's Urine-Based Liquid Biopsy Platform to be Presented at Two Upcoming Medical Conferences 2Clinical Data Featuring Trovagene's Urine-Based Liquid Biopsy Platform to be Presented at Two Upcoming Medical Conferences 3Clinical Data Featuring Trovagene's Urine-Based Liquid Biopsy Platform to be Presented at Two Upcoming Medical Conferences 4
... studied the marine trophic network in Mauritania, on the ... heavily exploited fishing area, as well as being home ... marine mammal the monk seal and the Atlantic ... industrial and traditional fishing activities along the coast are ...
... -- NASA,s newest Earth-observing research mission is nearing launch. ... the sun and tiny atmospheric particles called aerosols affect ... long-term solar measurements needed to address key uncertainties about ... from Vandenberg Air Force Base in California on Feb. ...
... a hormone best known for stimulating the production of red ... published by Cell Press in the January 27th issue of ... contrasting influences on infectious and inflammatory diseases and may be ... is a cytokine hormone that stimulates the production of red ...
Cached Biology News:Monk seal and hump-backed dolphin are threatened by fishing activities off coast of Mauritania 2NASA prepares to launch next Earth-observing satellite mission 2NASA prepares to launch next Earth-observing satellite mission 3Red blood cell hormone modulates the immune system 2
(Date:6/26/2015)... /PRNewswire/ - iCo Therapeutics ("iCo" or "the Company") (TSX-V: ... listed in the management information circular dated June 1, ... Meeting of Shareholders, held earlier today, June 26 ... 5 nominees proposed by management were elected as ... Company,s next Annual Meeting of Shareholders or until ...
(Date:6/26/2015)... , June 23, 2015 ... announced the addition of the "Global Cancer ... offering. Market introduction of cancer biosimilar ... and commercialization potential. Chemotherapeutic drugs have dominated the ... modalities have been introduced in past few years. ...
(Date:6/25/2015)... 25, 2015 ... announced the addition of the  "2015 ... Cancer Diagnostics Industry: Oncogenes, Biochemical Markers, ... Commercial Labs, POC Locations"  report ... (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , A ...
(Date:6/25/2015)... NEW YORK , June 25, 2015  The ... , Professor of Genome Sciences and Medical Genetics at ... the 2015 Pro Bono Humanum Award at the ninth ... ceremony.   The Pro Bono ... Professor King is the first woman recipient of the ...
Breaking Biology Technology:iCo Therapeutics Announces Voting & Election Results from Annual Meeting of Shareholders 2iCo Therapeutics Announces Voting & Election Results from Annual Meeting of Shareholders 3Global Cancer Biosimilars Market Opportunity Outlook 2Global Cancer Biosimilars Market Opportunity Outlook 3Analysis of the Global Cancer Diagnostics Industry 2015-2020: Oncogenes, Biochemical Markers, Lymphokines, GFs, CSFs, Hormones, Immunohistochemical Stains 2Analysis of the Global Cancer Diagnostics Industry 2015-2020: Oncogenes, Biochemical Markers, Lymphokines, GFs, CSFs, Hormones, Immunohistochemical Stains 3The Prix Galien USA Awards Committee Selects Professor Mary-Claire King as 2015 Pro Bono Humanum Honoree 2The Prix Galien USA Awards Committee Selects Professor Mary-Claire King as 2015 Pro Bono Humanum Honoree 3
... (Pink Sheets: BIEL), announced today that the ... sale by its,distributor, Endotherapeutics Party Limited. ... professionals of,Endotherapeutics will successfully launch ActiPatch in ... of experience in the,medical devices market and ...
... ... REDWOOD CITY, Calif., Oct. 9 Ingenuity Systems, ... science researchers,generate insights from biological and chemical information, ... to help researchers understand metabolomics data in the,context ...
... Drug Pipeline and Advancement of Clinical Programs, ... Inc.,(OTC Bulletin Board: AVGO), a late-stage biotechnology company ... today that it will be a presenting company ... held October 9-11, 2007 at the,Palace Hotel of ...
Cached Biology Technology:Australian Therapeutics Goods Administration Approval for ActiPatch Achieved 2Ingenuity Systems Launches New Metabolomics Solution Within IPA 2Avicena to Present at 4th Annual BIO InvestorForum Conference 2
MAb to Myoglobin Cardiac...
... The SDSaway reagent is a valuable tool ... The presence of SDS in biological ... tightly bound SDS-protein complex, inhibits enzymatic activity ... presents as a contaminant in mass spectrometry ...
Cells are grown to a specified density and induced, when necessary. Protein expression samples are collected at 3 growth points and analyzed by SDS-PAGE/Coomassie....
NovaScreen offers cell biology, cell culture and molecular biology services for companies who lack a cell culture facility....
Biology Products: