Navigation Links
To sleep, perchance to dream: New insight into melatonin production

In the April 1 issue of G&D, a Korean research team led by Dr. Kyong-Tai Kim (Pohang University) describes how melatonin production is coordinated with the body's natural sleep/wake cycles.

Melatonin is a hormone produced by the pineal gland in the brain, which helps to regulate our bodies' circadian rhythm (the roughly-24-hour cycle around which basic physiological processes proceed). Normally, melatonin production is inhibited by light and enhanced by darkness, usually peaking in the middle of the night. Melatonin's expression pattern is mimicked by a protein called AANAT, which is a key enzyme in the melatonin biosynthesis pathway.

Dr. Kim and colleagues uncovered the mechanism of rhythmic control of AANAT mRNA translation, and thereby melatonin synthesis. The researchers found that rodent AANAT mRNA translation is mediated by IRES (internal ribosome entry site) elements in the 5' end of the transcript, through binding of another protein, called hnRNP Q. In fact, siRNA knock-down of hnRNP Q reduced AANAT and melatonin production under nocturnal conditions.


'"/>

Source:Cold Spring Harbor Laboratory


Page: 1

Related biology news :

1. Brain-mapping technique aids understanding of sleep, wakefulness
2. Sleepless for science: Flies show link between sleep, immune system in Stanford study
3. New insight into people who see colors in letters and numbers
4. Alaskan puzzles, monitoring provide insight about North Pacific salmon runs
5. New insight into regulation of blood stem cells
6. New insight into autoimmune disease: Bacterial infections promote recognition of self-glycolipids
7. New insights into how Huntingtons disease attacks the brain
8. Gambling monkeys give insight into neural machinery of risk
9. Structures of marine toxins provide insight into their effectiveness as cancer drugs
10. Flies on speed offer insight into the roles of dopamine in sleep and arousal
11. Grasshopper love songs give insight into sensory tuning
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/13/2017)... HAMBURG, Germany , March 13, 2017 Future of ... ... DERMALOGs Face Matching enables to match ... characteristics forms the basis to identify individuals. (PRNewsFoto/Dermalog Identification Systems) ... DERMALOG,s "Face Matching" is the fastest software for ...
(Date:3/7/2017)... Brandwatch , the leading social intelligence company, today announces that it ... insights to support its reporting, help direct future campaigns, and share ... charity will be using Brandwatch Analytics social listening and analytics technology ... the topics and issues that are a priority for its supporters. ... "Until recently we,ve ...
(Date:3/2/2017)... Summary This report provides all the ... interests and activities since 2010. ... Read the full report: http://www.reportlinker.com/p03605615-summary/view-report.html ... report provides an in-depth insight into the partnering activity of ... On demand company reports are prepared upon purchase to ensure ...
Breaking Biology News(10 mins):
(Date:3/28/2017)... ... March 28, 2017 , ... ... for the Advancement of Science (AAAS), the world's largest general scientific society ... its high-impact scholarly collection across its cross-platform reference management system. , All ...
(Date:3/28/2017)... Ca (PRWEB) , ... March 28, 2017 , ... Mass ... settings. The utilization of this technology is driven by its potential to perform challenging ... there are also some challenges that must be addressed for it to be routinely ...
(Date:3/28/2017)... ... 28, 2017 , ... Benchworks announced that its ... The event was offered by the Chamber of Commerce for Greater Philadelphia and ... and interaction with speakers who are leaders in their industries. Topics included digital ...
(Date:3/28/2017)... ... March 28, 2017 , ... Triumph Modular ... Building Institute (MBI), an international modular trade organization, were awarded First Place, as ... the Pagliuca Life Lab at Harvard University. The awards were presented at the ...
Breaking Biology Technology: