Navigation Links
To Stop Evolution: New Way Of Fighting Antibiotic Resistance Demonstrated By Scripps Scientists

d Health Organization (WHO), large-scale epidemics of dysentery driven by this pathogen have been known to cause tens of thousands of deaths in Central America, South Asia, and central and southern Africa.

Treating multiple drug-resistant bacterial infections can be a hundred times more expensive than treating normal infections, and the WHO estimates the total cost of treating all hospital-borne antibiotic resistant bacterial infections is around $10 billion a year. Worse, with modern rapid transit and world travel, multiple drug-resistant bacteria could potentially spread beyond the isolated confines of a hospital and into the general population.

If one could design drugs to halt the enzymes that make mutations in bacteria, this could be a way of combating the evolution of antibiotic resistance.

The Dramatic Effect of LexA Inhibition

Halting evolution is exactly what Romesberg and his colleagues demonstrated in their latest PloS paper. They showed that when E. coli cells were treated with the antibiotics ciprofloxacin and rifampicin, they turned on their mutation pathways and rapidly evolved resistance to the antibiotics. Wanting to find the proteins that turn on the mutations, Romesberg and his colleagues identified a master regulatory switch that, if inhibited, blocks the ability of the cells to mutate.

This was the protein LexA, which belongs to the class of signaling enzymes known as serine proteases and works by cutting the amino acid chain of other proteins. Romesberg and his colleagues showed that LexA's action was necessary for the evolution of resistance to the antibiotics in vitro.

The effect in vivo was dramatic. Blocking LexA in rodent models of E. coli infections halted the growth of antibiotic resistance. Three days after being subjected to antibiotics, the rodents showed no level of resistance to rifampicin or ciprofloxin, when they harbored a variant of LexA that was catalytically inactive. In control
'"/>

Source:Scripps Research Institute


Page: 1 2 3 4 5 6

Related biology news :

1. Fighting malaria by manipulating mosquitoes sense of smell
2. Fighting like a girl or boy determined by gene in fruit flies
3. Fighting to keep Darwin in the classroom
4. Fighting influenza & co. with 40,000 blood samples
5. Antibiotic Resistant Bacterium Uses Sonar-like Strategy to “See?Enemies or Prey
6. Antibiotic might fight HIV-induced neurological problems
7. New Drugs For Bad Bugs: UF Approach Could Bolster Antibiotic Arsenal
8. Chemical Engineer Kao Explores Antibiotic Synthesis With DNA Chips
9. Use of Antibiotics for Acne May Increase Risk of Common Illness
10. Large-scale Computer Simulations Reveal New Insights Into Antibiotic Resistance
11. Antibiotic treats lymphoma of the eye
Post Your Comments:
(Date:9/18/2014)... BUFFALO, N.Y. A sleep-promoting circuit located deep in ... deep sleep. Discovered by researchers at Harvard School of ... and Biomedical Sciences, this is only the second "sleep ... to be both necessary and sufficient to produce deep ... Neuroscience , the study demonstrates that fully half of ...
(Date:9/18/2014)... Worcester, Mass. A novel robotic system that can ... currently being tested as part of a biomedical research ... with the aim of determining if the robot, in ... biopsies faster, more accurate, less costly, and less discomforting ... potential to deliver prostate cancer therapies with greater precision. ...
(Date:9/18/2014)... No matter how many times it,s demonstrated, it,s ... creatures. , But by using a signaling ... alter their behavior to suit their population. In ... are present, and act accordingly. , Once the ... may change from innocuous to pathogenic, or from ...
Breaking Biology News(10 mins):No sedative necessary: Scientists discover new 'sleep node' in the brain 2Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 2Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 3Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 4Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 5Researchers study vital 'on/off switches' that control when bacteria turn deadly 2Researchers study vital 'on/off switches' that control when bacteria turn deadly 3
... movements during the Vietnam war could help ecologists monitor ... in the British Ecological Society's Journal of Applied Ecology. ... recorded the vibrations from the footfalls of elephants and ... a geophone buried near a path leading to a ...
... discovered that a protein prolonging life in mice works by ... several species. In mice, the researchers discovered, it acts as ... , Therapies based on this hormone could prove to be ... Dr. Makoto Kuro-o, assistant professor of pathology and senior author ...
... Coyotes tend to avoid human contact. But recently, coyotes ... States, including southeastern New York state, attacking neighborhood pets ... "This kind of aggressive behavior is usually the last ... as small children that are perceived by the coyotes ...
Cached Biology News:Vietnam war technology could aid elephant conservation 2Scientists find that protein controls aging by controlling insulin 2Why are coyotes getting more aggressive? 2
(Date:9/18/2014)... 2014 Leatherwood Plastics has selected ... to stay competitive in the semiconductor, clean room ... ultimately impact product quality and productivity, according to ... Established in 1980 in Lewisville, TX, Leatherwood ... have left the business. Much of Leatherwood’s equipment ...
(Date:9/18/2014)... DIEGO , Sept. 18, 2014  MEI Pharma, Inc. ... the clinical development of novel therapies for cancer, announced today ... Executive Officer, will present at BioCentury,s NewsMakers in the ... 8:30 a.m. Eastern time from the Millennium Broadway Hotel & ... live webcast of the presentation can be accessed at ...
(Date:9/18/2014)... , Sept. 18, 2014 /PRNewswire/ - Oncothyreon Inc. ... of previously announced concurrent but separate underwritten offerings of ... to the public of $2.00 per share, for expected ... its Series A Convertible Preferred Stock at a price ... gross proceeds of $20 million. Each share of Series ...
(Date:9/18/2014)... 2014   Sigma-Aldrich Corporation (Nasdaq: ... into a new gene editing partnership with the ... Under the partnership, Sigma-Aldrich will provide the Vector ... and dedicated gene editing bioinformaticians. The ... at the U-M Medical School. One initiative already ...
Breaking Biology Technology:Leatherwood Plastics Selects Vycom’s Flametec PVC-C Material to Stay Competitive in Semiconductor and Lab Equipment Industries 2MEI Pharma To Present At BioCentury's NewsMakers Conference 2MEI Pharma To Present At BioCentury's NewsMakers Conference 3Oncothyreon Prices $40 Million Concurrent Public Offerings of Common Stock and Preferred Stock 2Oncothyreon Prices $40 Million Concurrent Public Offerings of Common Stock and Preferred Stock 3Sigma-Aldrich, University of Michigan Medical School Establish CRISPR Core Lab Partnership 2Sigma-Aldrich, University of Michigan Medical School Establish CRISPR Core Lab Partnership 3Sigma-Aldrich, University of Michigan Medical School Establish CRISPR Core Lab Partnership 4
... SAN DIEGO, April 28, 2011 Optimer Pharmaceuticals, Inc. ... from the DIFICID™ Phase 3 trials will be presented ... Place, Chicago, ILMay 7-10, 2011 Poster Presentation Information: Title: ... Treatment of Clostridium difficile Infection: ...
... Calif., April 28, 2011 AquaStar Holdings, Inc. (Pink ... that the United States Patent and Trademark Office has ... Sensor technology utilized by the Capwave Enzyme-Linked Immuno-Sorbent Assay ... Capillary Sensor" details research completed at the State University ...
... April 28, 2011 The Center for Business Intelligence (CBI), ... partnership with the Children,s Rare Disease Network and The Global ... coming up July 12 - 13, 2011 at the Doubletree ... about rare diseases. They affect few people individually, but there ...
Cached Biology Technology:Optimer Pharmaceuticals and Clinical Investigators to Present Data at Upcoming Medical Meetings 2Optimer Pharmaceuticals and Clinical Investigators to Present Data at Upcoming Medical Meetings 3AquaStar Holdings, Inc.'s Client Receives U.S. Patent 7,708,944 for Portable Capillary Sensor Technology 2CBI Announces Partnership With Children's Rare Disease Network and The Global Genes Project 2CBI Announces Partnership With Children's Rare Disease Network and The Global Genes Project 3
... Power Supply is designed specifically ... extensive programming capabilities including eight ... for you to set to ... intuitive PowerEase interface is faster ...
Assay Kit formatted for flow cytometric detection of levels of phosphorylated histone H2A.X....
... Z-Competent E. coli Transformation Buffer Set are ... E. coli cells for simple and highly ... eliminates the requirement for heat shocking and ... be performed by adding DNA to Z-Competent ...
Request Info...
Biology Products: