Navigation Links
To Stop Evolution: New Way Of Fighting Antibiotic Resistance Demonstrated By Scripps Scientists

ading mechanisms that would make even the most six-sigma-compliant NASA engineer jealous.

Nevertheless, all organisms are prone to some level of damage because no replication machinery is perfect, and with large genomes of billions of bases of DNA to be copied many billions of times over the lifetime of an organism, a certain level of spontaneous mutations will occur -- mistakes that escape repair and become part of the DNA of the cell in which they occur. Scientists have generally thought that slowly over time, these mutations accumulate and species diverge.

However, Romesberg and his colleagues believe that cells are not just the passive victims of random mutations, but have ways of initiating mutations in their own DNA. Evidence for this includes the fact that the rates of mutation in some cells does not seem consistent with the mutation rates associated with DNA replication.

Some cells, like bacteria subjected to antibiotics, seem to acquire mutations at a much higher rate. Romesberg reasons that these rapid mutations may sometimes be part of a mechanism organisms have to rapidly evolve when they need to.

Stress and Mutations

A few years ago, when he was first starting to think about this, Romesberg encountered a paper in a scientific journal that discussed certain genes that "make mutations," as he put it. When these genes are deleted from cells, the cells lose their ability to mutate, even when subjected to massive amounts of ultraviolet light.

This brought Romesberg to the conclusion that mutation is a programmed stress response -- a survival mechanism. If the cell senses damage, and if the damage persists beyond its ability to repair it, the cell will turn on its mutation machinery and open the floodgates for evolution.

Take the bacterium Escherichia coli for instance. When E. coli cells are subjected to damage, they upregulate repair enzymes, which then go to work trying to fix the problem. If the dama
'"/>

Source:Scripps Research Institute


Page: 1 2 3 4 5 6

Related biology news :

1. Fighting malaria by manipulating mosquitoes sense of smell
2. Fighting like a girl or boy determined by gene in fruit flies
3. Fighting to keep Darwin in the classroom
4. Fighting influenza & co. with 40,000 blood samples
5. Antibiotic Resistant Bacterium Uses Sonar-like Strategy to “See?Enemies or Prey
6. Antibiotic might fight HIV-induced neurological problems
7. New Drugs For Bad Bugs: UF Approach Could Bolster Antibiotic Arsenal
8. Chemical Engineer Kao Explores Antibiotic Synthesis With DNA Chips
9. Use of Antibiotics for Acne May Increase Risk of Common Illness
10. Large-scale Computer Simulations Reveal New Insights Into Antibiotic Resistance
11. Antibiotic treats lymphoma of the eye
Post Your Comments:
(Date:11/10/2014)... on U.S. store shelves in early 2010, and people ... small packets can be tossed into a washing machine ... powder. The convenience, though, has come with risks for ... Nationwide Children,s Hospital found that from 2012 through 2013, ... younger than 6 years of age swallowing, inhaling, or ...
(Date:11/6/2014)... paper from a team of Florida State University biologists ... could adapt to and survive environmental swings such as ... latest issue of the journal The Plant Cell ... DNA and proteins) is organized in a cell and ... are turned on and others are turned off. , ...
(Date:11/5/2014)... biology in the UTSA College of Sciences, is ... to receive a two-year $300,00 National Science Foundation ... The funding supports President Obama,s BRAIN Initiative, a ... technology that will demystify complex brain processes. ... are broken into the interactions of multiple components, ...
Breaking Biology News(10 mins):Study finds laundry detergent pods, serious poisoning risk for children 2Maize analysis yields whole new world of genetic science 2UTSA biology professor awarded $300,000 NSF grant for brain research 2UTSA biology professor awarded $300,000 NSF grant for brain research 3
... staple of laboratory research, may be key in ... sleep. Researchers at the University of Pennsylvania School of ... Nature that the round worm has a sleep-like state, ... physiology. This research has implications for explaining the evolution ...
... use their brains differently to solve the same ... in the first brain imaging study of its ... culture, which values the individual, emphasizes the independence ... societies emphasize the collective and the contextual interdependence ...
... moderate amount of weight get an immediate benefit in the ... at Washington University School of Medicine in St. Louis. And ... eating less or exercising more. "If individuals want to ... to them is lose weight by the method they find ...
Cached Biology News:Snoozing worms help Penn researchers explain the evolution of sleep 2MIT: Culture influences brain function 2Eat less or exercise more? Either way leads to more youthful hearts 2Eat less or exercise more? Either way leads to more youthful hearts 3Eat less or exercise more? Either way leads to more youthful hearts 4
(Date:11/24/2014)...  Last week, Representatives Gus Bilirakis ... a bold bipartisan step on behalf of patients ... Original co-sponsors of the legislation include Representatives McCaul ... drug makers and innovators to "repurpose" major market ... which opens the door to the development of ...
(Date:11/24/2014)... (PRWEB) November 23, 2014 One of the ... of optics and photonics is now available to high school ... low cost. SPIE, the international society for optics and ... the complete SPIE Digital Library available to high ... , “Light-based technologies are integral to all areas of life ...
(Date:11/24/2014)... 24, 2014  Spherix Incorporated (Nasdaq: ... the fostering and monetization of intellectual property, today ... Ltd.,  Case No. 3:13-cv-03494-M and  Spherix v. Uniden ... in the United States District Court for the ... On November 21, 2014 the ...
(Date:11/22/2014)... (PRWEB) November 21, 2014 During his ... understood the need to surround himself with great people ... and entrepreneur, his friends often marveled at his extraordinarily ... lived his life and -- even with his death ... the Alzheimer’s disease that would ultimately take his life. ...
Breaking Biology Technology:OPEN Act Introduced to Repurpose Drugs for Rare Diseases 2SPIE Digital Library Now Available to High Schools, Two-Year Colleges at No or Low Cost 2Markman Hearing Held as Scheduled in VTech and Uniden Cases 2Sherry Sharp, Wife of CarMax Founder, Richard Sharp, Accepts Seat on Board of Cure Alzheimer’s Fund 2Sherry Sharp, Wife of CarMax Founder, Richard Sharp, Accepts Seat on Board of Cure Alzheimer’s Fund 3
... Blood testing requirements removed, VANCOUVER, June 6 ... today that Health Canada has completed its review ... and has removed the,glucose-6-phosphate dehydrogenase (G6PD) screening and ... report Health Canada,s decision to remove,the need for ...
... 6 Quintiles,Transnational Corp. today announced the appointment ... Medical and Scientific Officer. Cabell,succeeds Oren Cohen, M.D., ... Strategies., As Chief Medical and Scientific Officer, ... on bioethics and the protection of,human subjects. In ...
... until January 2009 in the US ... - Pediatric indication filed with FDA, SMYRNA, Ga., June 6 ... has granted pediatric exclusivity for,Keppra(R) (levetiracetam). The decision was based on ... The Keppra(R) US,639 patent was set to expire in July 2008, ...
Cached Biology Technology:QLT announces positive Health Canada decision on Aczone(R) 2Quintiles Appoints Christopher Cabell to Chief Medical and Scientific Officer 2US FDA Grants Pediatric Exclusivity for UCB's Keppra(R) 2US FDA Grants Pediatric Exclusivity for UCB's Keppra(R) 3US FDA Grants Pediatric Exclusivity for UCB's Keppra(R) 4US FDA Grants Pediatric Exclusivity for UCB's Keppra(R) 5
ANTI ALPHA FSH:B...
... Beagle Serum • Beagle serum is ... over one year of age Available Anticoagulants: ... Heparin (Na) N-06: K2EDTA N-08: ... N-03: Alsevers N-05: ACD ...
MOUSE ANTI HUMAN MBP (67-74) Immunogen: Human myelin basic protein...
MOUSE ANTI BOVINE TROPONIN I...
Biology Products: