Navigation Links
Tissue regeneration operates differently than expected

at they are able to transmutate from one type of organ cell to another. If that is the case, bone marrow cells would be able to change into lots of different kinds of tissue cells ?for example, skeletal muscle cells.

Scientists led by Thomas Braun, Director of the Max Planck Institute for Heart and Lung Research, have discovered by a number of different experimental approaches that mesenchymal stem cells only show a rudimentarily developed potential for transdifferentiation processes. All cases in which functional skeletal muscle cells arose from mesenchymal stem cells were based on the fusion of stem cells with already differentiated muscle cells.

Although, like the researchers from Bad Nauheim show, cultivated mesenchymal stem cells are able to express a number of heart- and skeletal muscle specific genes and undergo some morphologic changes, after they are co-cultured with growth-factor producing feeder cells, finally they did not become entirely functional muscle cells.

Fully-functional muscle cells only developed after the mesenchymal stem cells were cultivated together with skeletal or heart muscle cells. This was indicated by the green fluorescence of muscle cells derived from the fusion with a stem cell which before had been labelled with the green dye. In contrast, no green fluorescing muscle cells became evident when stem and muscle cells were spatially separated by a membrane between both cell types. The researchers conclude that this experiments proofs that cell fusion of mesenchymal stem cells and muscle cell but not their transdifferentiation forms the basis for the regeneration mechanism. Additional experiments were focussing on the molecular mechanism underlying the cell fusion process. In these investigations, so-called "chimeric" mouse embryos were produced from mesenchymal stem cells and several mouse mutants: Obviously, the stem cells are recruiting the IL-4/NFAT signalling pathway which also is involved in the activation
'"/>

Source:Max-Planck-Gesellschaft


Page: 1 2 3

Related biology news :

1. Stem Cell Research Shows Potential for Replacing Tissue Damaged in Heart Attacks
2. Govt Creates Gene Database of Normal Human Tissues
3. Chronic Sinus Infection Thought To Be Tissue Issue, Mayo Clinic Scientists Show Its Snot
4. Tissue engineering for craniofacial reconstruction
5. Tissue engineered scaffolding allows reproduction of cartilage tissue
6. New component of the brakes on nerve regeneration found
7. Researchers feed tiny pills of RNA to planarians to identify genes essential for regeneration
8. New understanding of regeneration gained by Forsyth scientists
9. Protein-coated dental implants could improve bone regeneration
10. Rescuing injured hearts by enhancing regeneration
11. Key to zebrafish heart regeneration uncovered
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Tissue regeneration operates differently than expected

(Date:9/30/2014)... Health (NIH) awarded Lawrence Livermore National Laboratory (LLNL) ... system that will enable researchers to better understand ... scale. , LLNL,s grant-funded project is part of ... (Brain Research through Advancing Innovative Neurotechnologies) Initiative , ... of the human mind and uncover ways to ...
(Date:9/30/2014)... live in almost any aquatic environment on Earth, but ... species are pushed to the limit. The amount of ... critical for how different species cope in the future, ... of Gothenburg, published in the scientific journal Proceedings ... continues apace thanks to increasing levels of greenhouse gases ...
(Date:9/30/2014)... want your doctor to know what goes wrong with your ... idea to know what "normal" actually is. That,s where a ... the FASEB Journal comes in. In ... key set of molecules that can help scientists "see" which ... What,s more, they found never-before-detected gene activity and that men ...
Breaking Biology News(10 mins):NIH taps lab to develop sophisticated electrode array system to monitor brain act 2NIH taps lab to develop sophisticated electrode array system to monitor brain act 3Shape up quickly -- applies to fish, too! 2Scientists identify which genes are active in muscles of men and women 2
... researchers from Princeton University and the Drexel University College ... malaria breaks down an important amino acid in its ... By depleting this substance called arginine, the parasite may ... disease. The scientists believe that shedding light on ...
... and University of Malaya (UM) today announced the establishment ... This is the first Centre of its kind in ... communities in terms of their diet and disease, conducting ... environment and health, providing assistance for the national cancer ...
... of the oil in the ocean bubbles up naturally from ... was of no value. Likewise, NASA satellites collect thousands of ... of it gets passed over because no one thinks there ... black gold bubbling up from an otherwise undistinguished mass of ...
Cached Biology News:Malaria parasite zeroes in on molecule to enhance its survival, team finds 2Malaria parasite zeroes in on molecule to enhance its survival, team finds 3Queen's University Belfast improves Malaysian public health 2Scientists find black gold amidst overlooked data 2Scientists find black gold amidst overlooked data 3
(Date:9/30/2014)... 2014  RegeneRx Biopharmaceuticals, Inc. (OTC: RGRX) ("the ... received a Canadian Patent for Inhibition or Reversal ... includes claims using thymosin beta 4, various fragments ... these purposes.  The patent will expire in 2021. ... www.regenerx.com ) RegeneRx is focused ...
(Date:9/30/2014)... Sept. 30, 2014  KemPharm, Inc., a clinical-stage ... development of proprietary new molecular entity (NME) prodrugs, ... Trademark Office (USPTO) issued U.S. Patent No. 8,816,083 ... Acid, Benzoic Acid Derivatives and Heteroaryl Carboxylic Acid ... Use Thereof." The patent, which extends ...
(Date:9/30/2014)... (PRWEB) September 30, 2014 The custom ... ISPE Boston Product Show 2014. The Boston Area Chapter ... the 23rd annual, day-long event for Wed., Oct. 1 ... promises to be the largest in ISPE Boston’s long ... upward of 3,000 attendees expected. , HOLLOWAY AMERICA ...
(Date:9/30/2014)... September 30, 2014 UFP Technologies, ... specialty packaging has recently introduced a custom insulated ... Pack . The new insulated shipper solves the ... distribution process. UFP Technologies’ BioShell is a universal ... during storage, handling and shipping. The insulated shipper ...
Breaking Biology Technology:RegeneRx Receives Canadian Patent for Inhibition or Reversal of Skin Aging 2KemPharm, Inc. Receives Patent from the USPTO for Novel Prodrug of Hydromorphone, KP511 2HOLLOWAY AMERICA to Exhibit at ISPE Boston Product Show 2014 2HOLLOWAY AMERICA to Exhibit at ISPE Boston Product Show 2014 3UFP Technologies Introduces Insulated Shipping Container For Bulk Drug Transportation 2UFP Technologies Introduces Insulated Shipping Container For Bulk Drug Transportation 3
... of a three-part series focusing on the past, present and future of ... to WTNs interview with Nettles in March 2003. , , ... the next six to 12 months, what Dept. of Commerce initiatives would ... I had a meeting with Gov. Doyle a couple of weeks ...
... people who helped North Carolina and Los Angeles become ... of angel investors shared their most effective practices Tuesday ... ,Their techniques included educational programsbut you have to be ... the Council for Entrepreneurial Development , based in ...
... The second annual Wisconsin Entrepreneurs Conference got off to a ... treating at least a hundred entrepreneurs and industry representatives to ... The entrepreneurial boot camp was designed serve both veteran ... success from a panel of seasoned industrialists. , ,Our purpose ...
Cached Biology Technology:WTN exclusive interview with Commerce Secretary Cory Nettles (part 2) 2WTN exclusive interview with Commerce Secretary Cory Nettles (part 2) 3WTN exclusive interview with Commerce Secretary Cory Nettles (part 2) 4WTN exclusive interview with Commerce Secretary Cory Nettles (part 2) 5Experts share advice for Wisconsin entrepreneur programs 2Experts share advice for Wisconsin entrepreneur programs 3Experts share advice for Wisconsin entrepreneur programs 4Entrepreneurs get crash course for building a successful company 2Entrepreneurs get crash course for building a successful company 3
Makes gels easy to load and track during electrophoresis. 10X concentrate of Bromophenol Blue, Xylene Cyanol, glycerol solution in TE...
Xanthine Oxidase (Bovine Buttermilk). Monospecific by IEP. Some cross reactivity with Xanthine Oxidase of other species and tissues may occur....
Rabbit polyclonal to XTP4 ( Abpromise for all tested applications). entrezGeneID: 84299 SwissProtID: Q9BRT3...
Low melting point. Ideally suited for in gel enzymatic reactions. Gelling temp. 24-28C Melting temp. 65C. EEO 0.12 Resolution 0.5-20 kb; Rnase/Dnase: none detected....
Biology Products: