Navigation Links
Tissue regeneration operates differently than expected

at they are able to transmutate from one type of organ cell to another. If that is the case, bone marrow cells would be able to change into lots of different kinds of tissue cells ?for example, skeletal muscle cells.

Scientists led by Thomas Braun, Director of the Max Planck Institute for Heart and Lung Research, have discovered by a number of different experimental approaches that mesenchymal stem cells only show a rudimentarily developed potential for transdifferentiation processes. All cases in which functional skeletal muscle cells arose from mesenchymal stem cells were based on the fusion of stem cells with already differentiated muscle cells.

Although, like the researchers from Bad Nauheim show, cultivated mesenchymal stem cells are able to express a number of heart- and skeletal muscle specific genes and undergo some morphologic changes, after they are co-cultured with growth-factor producing feeder cells, finally they did not become entirely functional muscle cells.

Fully-functional muscle cells only developed after the mesenchymal stem cells were cultivated together with skeletal or heart muscle cells. This was indicated by the green fluorescence of muscle cells derived from the fusion with a stem cell which before had been labelled with the green dye. In contrast, no green fluorescing muscle cells became evident when stem and muscle cells were spatially separated by a membrane between both cell types. The researchers conclude that this experiments proofs that cell fusion of mesenchymal stem cells and muscle cell but not their transdifferentiation forms the basis for the regeneration mechanism. Additional experiments were focussing on the molecular mechanism underlying the cell fusion process. In these investigations, so-called "chimeric" mouse embryos were produced from mesenchymal stem cells and several mouse mutants: Obviously, the stem cells are recruiting the IL-4/NFAT signalling pathway which also is involved in the activation
'"/>

Source:Max-Planck-Gesellschaft


Page: 1 2 3

Related biology news :

1. Stem Cell Research Shows Potential for Replacing Tissue Damaged in Heart Attacks
2. Govt Creates Gene Database of Normal Human Tissues
3. Chronic Sinus Infection Thought To Be Tissue Issue, Mayo Clinic Scientists Show Its Snot
4. Tissue engineering for craniofacial reconstruction
5. Tissue engineered scaffolding allows reproduction of cartilage tissue
6. New component of the brakes on nerve regeneration found
7. Researchers feed tiny pills of RNA to planarians to identify genes essential for regeneration
8. New understanding of regeneration gained by Forsyth scientists
9. Protein-coated dental implants could improve bone regeneration
10. Rescuing injured hearts by enhancing regeneration
11. Key to zebrafish heart regeneration uncovered
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Tissue regeneration operates differently than expected

(Date:12/24/2014)... , Dec. 23, 2014  Since its launch in December 2014, the ... eliminate the pain of trying to remember their usernames and ... fused to their smartphones. To assist people who have struggled ... company that created 1U and focuses on redefining identity, announced ...
(Date:12/19/2014)... , Dec. 18, 2014 Research and Markets ... "Micro Market Monitor: North America Perimeter Security Systems Market" ... The North American perimeter security market is ... to 2019. Although the U.S. market holds a larger share ...
(Date:12/17/2014)... NEW YORK , Dec. 15, 2014  HITLAB SM ... Practices (GCP) audit to confirm its adherence to current ... enables HITLAB to conduct regulated smart device and smart ... safety and research quality. "HITLAB is determined ...
Breaking Biology News(10 mins):1U Offers Best Solution to the Username / Password Dilemma: For FREE! 21U Offers Best Solution to the Username / Password Dilemma: For FREE! 3Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 3HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2
... may help to protect against some food allergies. Kefir, a ... health food, and is often used to wean babies, as ... in children under the age of three, with around 5-8% ... of the problematic food. , "Friendly" bacteria in kefir may ...
... in the event of a large-scale smallpox bioterrorist attack ... by researchers at Fred Hutchinson Cancer Research Center that ... , Instead, the current U.S. government policy of post-release ... workers and close contacts would be sufficient to thwart ...
... information is passed from parents to offspring via sperm or ... as yeast, the genes can be passed to the next ... occur in the genetic material after it has been duplicated ... mature gametes or spores. Near the end of the process, ...
Cached Biology News:Friendly bacteria in alcoholic milkshake could fight food allergies 2Mass vaccination unnecessary in the event of a large bioterrorist US smallpox attack 2Mass vaccination unnecessary in the event of a large bioterrorist US smallpox attack 3Mass vaccination unnecessary in the event of a large bioterrorist US smallpox attack 4Mass vaccination unnecessary in the event of a large bioterrorist US smallpox attack 5Single molecular 'mark' seen as pivotal for genome compaction in spores and sperm 2
(Date:1/23/2015)... , Jan. 23, 2015  Array BioPharma Inc. (NASDAQ: ... reached a definitive agreement with Novartis Pharma AG to ... currently in Phase 3 development.  This agreement is conditional on ... PLC (GSK) on April 22, 2014, which are expected to ...
(Date:1/22/2015)... GEA Niro Soavi the leader in ... the PandaPLUS 2000, which is ideal for new applications ... cell disruption . This compact laboratory homogenizer is the ... food, food additives and ingredients as well as for ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Crystal Diagnostics (CDx) ... that it has received AOAC-PTM Certifications for the six non-O157 ... and O145; collectively referred to as STEC or the “Big-6”) ... colony forming unit (cfu) per 325 g of raw ground ...
(Date:1/22/2015)... Switzerland (PRWEB) January 22, 2015 Selexis ... characterized mammalian Research Cell Banks (RCBs) used for drug ... Research Cell Banks will include Next-Generation Sequencing ... genetic architecture de-risks biologic manufacturing by ensuring the integrity ...
Breaking Biology Technology:Array Announces Agreement To Acquire ENCORAFENIB (LGX818) 2Array Announces Agreement To Acquire ENCORAFENIB (LGX818) 3Array Announces Agreement To Acquire ENCORAFENIB (LGX818) 4Array Announces Agreement To Acquire ENCORAFENIB (LGX818) 5Array Announces Agreement To Acquire ENCORAFENIB (LGX818) 6Array Announces Agreement To Acquire ENCORAFENIB (LGX818) 7GEA Niro Soavi Announces the PandaPLUS 2000 Homogenizer for Processing New Applications for Nanoemulsions and Cell Disruption 2Crystal Diagnostics Awarded AOAC-PTM Accreditation for the Rapid Detection of “Big 6” E.coli Food Pathogens 2Selexis Generated Research Cell Banks Now Fully Sequenced Using Next-Generation Sequencing 2
... WASHINGTON - A delegation led by Governor Doyle and ... week for the biotechnology industrys leading conference with goals ... states research and university community and to let others ... to members of the group, the delegation met its ...
... get difficult, its the companies who dont panic, that will ... years ago, I was working on a project for the ... San Jose, California. I was arranging and conducting seminars for ... again going through a make or break situation with many ...
... WI - GE Medical Systems, a unit of General ... by the U.S. Food and Drug Administration to begin ... (MRI) system. The Signa EXCITE 3.0T combines the increased ... with the breadth of imaging capabilities found on premium ...
Cached Biology Technology:On site at BIO 2003 2On site at BIO 2003 3On site at BIO 2003 4On site at BIO 2003 5A Race without a Finish Line! 2GE Medical Systems Receives FDA Clearance for New MRI System 2
Recombinant DNA polymerase from Thermus aquaticus expressed in E. coli; 5 units/L; 1 tube of 1, 000 units enzyme/tube w/Buffer II and MgCl2...
Recombinant DNA polymerase from Thermus aquaticus expressed in E. coli; 5 units/uL; 25 tubes of 1, 000 units enzyme/tube w/ Buffer I...
A robust formulation of Taq Polymerase supplied with a 10X colored reaction buffer which allows Direct Gel-Loading...
Ps-Aeruginosa (IgA) -Ab EIA Sample Size: 100 l...
Biology Products: