Navigation Links
Tiny scaffolding allows stem cells to become working fat cells

Researchers here have used a new microscopic, three-dimensional scaffolding to coax mouse stem cells to transform themselves into fat cells, and then to function identical to how fat cells naturally do in the body.

While other studies have previously grown fat cells, or adipocytes, in the laboratory, those cells never completely functioned in the same way they do in normal tissue. They failed to produce the genetic and biologic components that all cells require to do their work.

This discovery offers hope of a new approach to growing fat tissue for use in breast reconstruction surgery and other clinical needs, and may even be important for curing type II diabetes.

Douglas Kniss, professor of obstetrics and gynecology and of biomedical engineering at Ohio State University, reported this progress in the current issue of the journal Tissue Engineering.

"There is a serious shortage of transplantable organs available for thousands of patients nationally," Kniss said. "One ultimate goal of this work might be creating new tissue that could serve either as a temporary substitute while waiting for a donor organ, or even providing a replacement organ."

Along with Xihai Kang and Yubing Xie, both postdoctoral fellows in his laboratory, Kniss built a fabric-like carpet of polyethylene terephathalene (PET), or Dacron, fibers that served as scaffolding upon which new fat cells were grown.

In conventional cell cultures, cells usually grow as flat deposits bathed in growth medium. While useful, these "two-dimensional" patches fail to mimic all the tasks performed by cells in vivo. Specific genes, proteins and hormones normally produced by healthy cells are often absent in two-dimensional colonies.

"The PET fibers are spun out onto a mat that resembles the intracellular matrix that bonds cells together in normal tissue. The fibers are about the size of a collagen fiber, several nanometers (a billionth of a meter) across, and prov
'"/>

Source:Ohio State University


Page: 1 2 3

Related biology news :

1. Microscopic scaffolding offers a simple solution to treating skin injuries
2. Bedsores and bald hides: Novel roles revealed for a scaffolding protein
3. Tissue engineered scaffolding allows reproduction of cartilage tissue
4. Researchers find how protein allows insects to detect and respond to pheromones
5. Enzyme allows B cells to resist death, leading to leukemia
6. Looks matter to female barn swallows
7. New law for resolution allows unprecedented sharpness in fluorescence microscopy
8. Stolen gene allows insect virus to enter cells
9. Researchers identify molecular anchor that allows bacterial invasion of central nervous system
10. Algal protein in worm neurons allows remote control of behavior by light
11. Why nerve cells work faster than the theory allows
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Tiny scaffolding allows stem cells become working fat cells

(Date:7/11/2014)... Researchers have pioneered a revolutionary new way ... called Virtual Finger, allows scientists to move through ... synapses using the flat surface of their computer ... studies orders of magnitude more efficient, saving time, ... many areas of experimental biology. The software and ...
(Date:7/11/2014)... the hippocampus, the marginal division of the striatum ... is the impact degree of substance P in ... function? Yan Yu and his team, College of ... immunofluorescence staining, that substance P receptor, neurokinin 1 ... marginal division of normal rats. Unilateral or bilateral ...
(Date:7/11/2014)... 2014 Research and Markets has ... Market - Industry Analysis Size Share Growth Trends and ... http://photos.prnewswire.com/prnh/20130307/600769 The ... a need for high level security in both private ... such as username and passwords, tokens etc. are vulnerable ...
Breaking Biology News(10 mins):Virtual finger enables scientists to navigate and analyze complex 3D images 2International Biometrics Technology Market - Industry Analysis Size Share Growth Trends and Forecast to 2019 2
... calories leads to a longer life, scientists have proved. ... time that such a diet also can maintain physical ... to physical disability and loss of independence. The study, ... that the diet reduces the amount of visceral fat, ...
... to their social behavior, people sometimes act like monkeys, ... monkey that shares with humans strong tendencies for nepotism ... an expert on primate behavior and an Associate Professor ... University of Chicago. After humans, rhesus macaques are ...
... at Case Western Reserve Universitys School of Medicine ... remarkable discovery with a natural product derived from ... a broad set of applications in various joint, ... bowel syndrome., The publication revealed that Progrado, an ...
Cached Biology News:Severely restricted diet linked to physical fitness into old age 2Humans and monkeys share Machiavellian intelligence 2Humans and monkeys share Machiavellian intelligence 3Natural product discovery by Cleveland medical researchers blocks tissue destruction 2
(Date:7/11/2014)... SEATTLE , July 11, 2014  Researchers ... navigate three-dimensional images. The new technology, called Virtual ... of small structures like neurons and synapses using ... Finger,s unique technology makes 3D imaging studies orders ... resources at an unprecedented level across many areas ...
(Date:7/10/2014)... Canada (PRWEB) July 10, 2014 ... present in very low abundance and are often ... challenging and time-consuming. , Join presenters Dr. Rowel ... and Dr. John Anders, Head of Quality at ... spectrometer-based approach that can speed detection and quantitation ...
(Date:7/10/2014)... 10, 2014 Terascala, the industry leader ... Alan Swahn, a former vice president of product management ... vice president of marketing. Terascala’s software when combined with ... create the highest performance and most reliable solutions for ... guide Terascala’s channel expansion and broaden its product portfolio. ...
(Date:7/10/2014)... 2014 OMICS Group’s 5th International conference ... August, 2014 at Double Tree by Hilton Beijing, China ... in Analytical & Bioanalytical research methods only to facilitate ... this occasion, Dr. Srinubabu Gedela, MD of OMICS Group ... a remarkable one in bringing a unique and international ...
Breaking Biology Technology:Virtual Finger Enables Scientists To Navigate And Analyze 3D Images Of Complex Biological Structures 2Virtual Finger Enables Scientists To Navigate And Analyze 3D Images Of Complex Biological Structures 3Novel Ms Techniques Speed Detection of Biopharmaceutical Product and Process Impurities, New Webinar Hosted by Xtalks 2Terascala Expands Executive Team 2Terascala Expands Executive Team 3A Critical Review of Analytical Techniques for Improved Living Standards 2A Critical Review of Analytical Techniques for Improved Living Standards 3A Critical Review of Analytical Techniques for Improved Living Standards 4
... 19, 2011 Advances that CSL Behring is ... therapeutic needs of patients with hemophilia A and B will ... medical congress on May 22, 2011. CSL Behring is a ... is a subsidiary of CSL Limited (ASX:CSL). ...
... May 19, 2011 Advantagene, Inc., a Massachusetts-based biopharmaceutical ... the U.S. Food and Drug Administration on a Special ... trial of ProstAtak™, its lead agent for patients with ... accrue 711 patients starting mid-2011 with definitive results expected ...
... 19, 2011 Reportlinker.com announces that a ... its catalogue: Global Biosimilars ... This report analyzes the worldwide ... report provides separate comprehensive analytics for US, ...
Cached Biology Technology:Overview of CSL Behring Innovations in Recombinant Technologies Presented at International Conference 2Overview of CSL Behring Innovations in Recombinant Technologies Presented at International Conference 3Advantagene Announces SPA Agreement With FDA to Launch Phase 3 Trial for Novel Vaccine Aimed at Preventing Prostate Cancer Recurrence 2Global Biosimilars Industry 2Global Biosimilars Industry 3Global Biosimilars Industry 4Global Biosimilars Industry 5Global Biosimilars Industry 6Global Biosimilars Industry 7Global Biosimilars Industry 8Global Biosimilars Industry 9Global Biosimilars Industry 10
... The mini incubation trays ... used to screen antigens that ... membrane. Each tray has eight ... channels that accommodate strips cut ...
... analysis and experiment control software. Records ... on-line and off-line analysis. powerful stimulus ... language allowing the user to customize ... Applications range from basic data logging ...
... • Small design specifically for western ... ,Trays are specifically designed for staining western ... x 25 mm) of the disposable tray ... a significant cost savings to the user. ...
... a direct antibiotic-based selection ... Recombinant selection depends solely ... the need for costly ... and inexpensive process provides ...
Biology Products: