Navigation Links
Tiny roundworm's telomeres help scientists to tease apart different types of aging

ogical age? To answer these vexing questions, Karlseder, who is interested in telomeres, teamed up with Dillin, who studies lifespan and aging in C. elegans.

Researchers use this 1 millimeter-long soil roundworm that feeds on bacteria mainly because it is simple, easy to grow in bulk populations, and is quite convenient for genetic analysis.

When these scientists began their work almost nothing was known about worm telomeres. "We had to start at the very beginning. But now we know that C. elegans is the perfect model organism to study telomere biology since their regulation is similar to human telomeres," says first author Marcela Raices, a post-doctoral researcher in Karlseder's lab.

Many cells in our body keep dividing throughout life (e.g., those that line our digestive tract, blood, and immune cells) because they must be replaced over time. When these cells' telomeres reach a critically short length, however, they can no longer replicate. The cell's structure and function begin to fail as it enters this state of growth arrest, called replicative senescence.

"But even in very old people, blood cells, which divide continuously, don't have critically short telomeres. In humans and, as we know now, in worms, telomere length is certainly not a limiting factor for lifespan," says Karlseder.

The Salk team, which also included graduate student Hugo Maruyama, found that despite the close correlation of telomere length and cellular senescence in mammalian cells, worms with long telomeres were neither long lived, nor did worm populations with short telomeres exhibit a shorter life span. On the other hand, long-lived and short-lived mutant worms could have them either way without any effect on their lifespan. When Raices monitored telomere length over the full lifespan of worms and under stress, a situation reported recently at another laboratory to shorten telomeres in humans, she found absolutely no change.

"For successful a
'"/>

Source:Salk Institute


Page: 1 2 3

Related biology news :

1. Wisconsin scientists grow critical nerve cells
2. UCSB scientists probe sea floor venting to gain understanding of early life on Earth
3. UAB scientists discover the origin of a mysterious physical force
4. Fox Chase Cancer Center scientists identify immune-system mutation
5. Weizmann Institute scientists develop a new approach for directing treatment to metastasized prostate cancer in the bones.
6. U-M scientists find genes that control growth of common skin cancer
7. UCLA scientists transform HIV into cancer-seeking missile
8. RNA project to create language for scientists worldwide
9. Carnegie Mellon scientists develop tool that uses MRI to visualize gene expression in living animals
10. To control germs, scientists deploy tiny agents provocateurs
11. Leprosy microbes lead scientists to immune discovery
Post Your Comments:
(Date:12/17/2014)... 2014  Automation is fundamentally transforming the travel ... at international borders. Over the past decade, ePassports, ... veteran travelers to self process through border control ... at an increasing number of airports, seaports, and ... According to Maxine Most , Principal at ...
(Date:12/11/2014)... , Dec. 09, 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/9ql3kr/biometrics_market ) has announced ... India 2015-2019" report to their offering. ... market is the adoption of multimodal biometric systems. ... of an individual for verification and identification purposes. ...
(Date:12/10/2014)... -- You,ve been here before: you desperately need to sign ... site key or the answer to your secret question. What,s ... Today, Hoyos Labs , a digital infrastructure ... put an end to the frustration that comes with usernames, ... leverages a user,s smartphone to acquire his or her biometrics ...
Breaking Biology News(10 mins):Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 3
... tissue and organ transplantation for diseases that are caused ... ethical discussions surrounding human embryonic stem cells, a lot ... (iPS cells). However, before this technique can be applied ... safety and efficacy of such iPS cells. VIB scientists ...
... omega-3 fatty acids can inhibit growth of breast cancer tumours ... University of Guelph. The study, published recently in the ... the first to provide unequivocal evidence that omega-3s reduce cancer ... professor in Guelph,s Department of Human Health and Nutritional Sciences, ...
... New analysis of data from the National Health ... the Centers for Disease Control and Prevention (CDC), indicates ... quality and nutrient intake level, lower intake of added ... "good cholesterol" levels and lower metabolic syndrome risk. These ...
Cached Biology News:Cell therapy a little more concrete thanks to VIB research 2Omega-3s inhibit breast cancer tumor growth, study finds 2New study indicates avocado consumption may be associated with better diet quality 2
(Date:12/17/2014)... Based on the revenues gained ... market is dominated by four major players contributing ... These players include GE Healthcare (U.K.), Siemens AG ... , Full Report Copy at http://www.marketsandmarkets.com/Market-Reports/surgical-imaging-market-210534462.html ... be attributed to its strong product portfolio, which ...
(Date:12/17/2014)... December 17, 2014 Ipsen Biopharmaceuticals, ... IPN; ADR: IPSEY), today announced that ... as Somatuline®) was approved by the U.S. Food ... gastroenteropancreatic neuroendocrine tumors (GEP-NETs) in adult patients with ... metastatic disease to improve progression-free survival (PFS). , ...
(Date:12/17/2014)... Indianapolis, IN (PRWEB) December 17, 2014 ... for Laboratory Excellence following its most recent COLA ... Accreditation by COLA, a national healthcare accreditation organization. ... rigid standards of quality in day-to-day operations, demonstrate ... and pass a rigorous on-site laboratory survey. ...
(Date:12/17/2014)... 16, 2014  Vermillion, Inc. (NASDAQ: VRML ... today announced the next step in its expanded strategy ... provider with the naming of current Chief Operating Officer, ... Officer, while current Chairman of the Board and CEO ... Chairman. These changes are effective January 1, 2015. ...
Breaking Biology Technology:Global Refurbished Surgical Imaging Market by Product & Application is Estimated to Reach $1.25 Billion by 2019 - New Research Report by MarketsandMarkets 2Global Refurbished Surgical Imaging Market by Product & Application is Estimated to Reach $1.25 Billion by 2019 - New Research Report by MarketsandMarkets 3Global Refurbished Surgical Imaging Market by Product & Application is Estimated to Reach $1.25 Billion by 2019 - New Research Report by MarketsandMarkets 4Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 2Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 3Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 4Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 5Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 6Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 7Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 8Xeno Diagnostics Receives 3rd Award for Laboratory Excellence 2Vermillion Names Valerie Palmieri CEO; James LaFrance to continue as Chairman of Board 2Vermillion Names Valerie Palmieri CEO; James LaFrance to continue as Chairman of Board 3Vermillion Names Valerie Palmieri CEO; James LaFrance to continue as Chairman of Board 4
... lecture and present a poster on proprietary siRNA ... targeting ... Quark Pharmaceuticals, Inc., a,development-stage pharmaceutical company discovering and developing ... the Cambridge Healthcare Institute,s 9th Annual Beyond,Genome Conference on ...
... than 30 years ago, when Northwestern University chemist Richard Van ... he would be using it to learn more about treasures ... watercolor recently featured in the museum,s exhibition "Watercolors by Winslow ... to be a Farmer,s Boy," painted in 1887, some of ...
... than $120,000 in the prestigious Race Across America the past two years, ... ... Wednesday, June 11,2008, Renato Shaffer will begin riding his bike for the third ... Disease, the fatal,brain disease that affects his wife and threatens his two daughters., ...
Cached Biology Technology:Quark Pharmaceuticals to Participate in 9th Annual Beyond Genome Conference 2Quark Pharmaceuticals to Participate in 9th Annual Beyond Genome Conference 3Northwestern chemist investigates lost reds in Homer painting 2HDSA-San Diego's Team 2CureHD Continues its Race to Cure Huntington's Disease 2
... Protein Purification Protocols covers a wide ... for novice and experienced researchers in all ... This excerpt from the books preface illustrates ... to your research library., The chapters introduce ...
... Cellular uptake of long double stranded RNA ... interference in a diverse group of organisms ... RNA interference leads to the inhibition of ... of the target messenger RNA (mRNA). Attempts ...
... TrackerCumulates a score of movement counts, similar ... it.can track up to 6 subjects at once, ... triggered. Test a whole experimental group at ... the activity. Upgradeable for a variety of ...
... examining a novel object in the environment.The Spatial ... built around a video camera, frame grabber, and ... fields at once and up to 6 moving ... records them, but also allows video replay of ...
Biology Products: