Navigation Links
Tiny roundworm's telomeres help scientists to tease apart different types of aging

The continual and inevitable shortening of telomeres, the protective "caps" at the end of all 46 human chromosomes, has been linked to aging and physical decline. Once they are gone, so are we. But there are more ways than one to grow old.

Researchers at Salk Institute for Biological Studies demonstrate for the first time that the roundworm Caenorhabditis elegans succumbs to the trials of old age although its telomeres are still long, and moves with a youthful spring in its crawl despite short telomeres, they report in PLoS Genetics, available online now.

In the past, preventing telomere shortening has often been portrayed as the key to preventing aging and living longer. In their study, Salk scientists Jan Karlseder, an assistant professor in the Regulatory Biology Laboratory, and Andrew Dillin, an assistant professor in the Molecular and Cell Biology Laboratory, provide a much more nuanced view of telomeres and the process of cellular and organismal aging.

"Some long-lived species like humans have telomeres that are much shorter than the telomeres in species like mice, which live only a few years. Nobody yet knows why. But now we have conclusive evidence that telomeres alone do not dictate aging and lifespan," says Karlseder.

Each time a cell divides, its telomeres get shorter, a process called replicative or cellular aging. Some have likened this progressive erosion of telomeres to a genetic biological clock that winds down over time, leading to a gradual decline in our mental and physical prowess. Yet, C. elegans, a tiny creature, which spends the better part of its adult life without a single dividing cell in its body, still shows signs of old age and eventually dies, raising intriguing questions.

Are telomeres in non-dividing cells eroding slowly over time? If so, will worms with longer telomeres live longer? If not, how do worm cells and by extension non-dividing human cells, such as nerve cells, keep track of their biol
'"/>

Source:Salk Institute


Page: 1 2 3

Related biology news :

1. Wisconsin scientists grow critical nerve cells
2. UCSB scientists probe sea floor venting to gain understanding of early life on Earth
3. UAB scientists discover the origin of a mysterious physical force
4. Fox Chase Cancer Center scientists identify immune-system mutation
5. Weizmann Institute scientists develop a new approach for directing treatment to metastasized prostate cancer in the bones.
6. U-M scientists find genes that control growth of common skin cancer
7. UCLA scientists transform HIV into cancer-seeking missile
8. RNA project to create language for scientists worldwide
9. Carnegie Mellon scientists develop tool that uses MRI to visualize gene expression in living animals
10. To control germs, scientists deploy tiny agents provocateurs
11. Leprosy microbes lead scientists to immune discovery
Post Your Comments:
(Date:5/14/2015)... May 14, 2015 Research and Markets ... "Fingerprint Sensors Market in Smart Mobile Devices " ... believes that 2014 was a watershed year for fingerprint ... of ,Apple Pay,. Apple gave fingerprint sensors a raison ... service. Fingerprint sensors are a must-have feature in flagship ...
(Date:5/11/2015)... , May 11, 2015 Curemark LLC, a ... start of a new Phase III double blind, randomized, ... novel formulation, CM-AT, on all children ages 3-8 with ... FDA Phase III double blinded clinical trial for CM-AT ... levels of the digestive enzyme chymotrypsin. This new trial ...
(Date:5/6/2015)... , May 6, 2015 LifeBEAM, a developer ... helmet producer, announced today that they will expand their ... world,s first bio-sensing cycling helmet and the first joint ... two new colors in order to give cyclists more ... In addition, LifeBEAM and Lazer announced their plan to ...
Breaking Biology News(10 mins):Global Smart Mobile Devices Fingerprint Sensors Market 2015-2019: Key Vendors are Authentec, Validity Sensors, Fingerprint Cards, Next Biometrics Group. IDEX, and Qualcomm 2Curemark, LLC, Launches New Phase III Trial in Expanded Population of Children with Autism 2LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 2LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 3
... Diabetes Center have found genetic regions that, when defective, allow ... a series of mis-steps that lead to type 1 diabetes. ... Immunity, the researchers are now trying to hone in on ... , “The significance of this study is that we found ...
... found to defy the most basic tenet of sexual ... sex, according to Howard Hughes Medical Institute researchers at ... 2005, issue of Nature, the researchers reported that, in ... "sex" can mate and produce offspring. Infection with the ...
... identified the proteins that allow specific brain cells to "change ... the cell. The findings, described in the March 24 issue ... day using it to protect cells that die in Lou ... what comes into the living room, these brain cells are ...
Cached Biology News:Genetic defects give the immune system the green light to attack the pancreas 2Genetic defects give the immune system the green light to attack the pancreas 3Same-Sex Mating Discovered in a Toxic Fungus 2Same-Sex Mating Discovered in a Toxic Fungus 3Some Brain Cells 'Change Channels' To Fine-tune The Message 2Some Brain Cells 'Change Channels' To Fine-tune The Message 3
(Date:5/28/2015)... Biscayne Pharmaceuticals, Inc ., today announced ... hormone-releasing hormone (GHRH) technology will be discussed in a ... The data show that the family of receptors for ... present on many primary breast cancer cells regardless of ... could have broad anti-cancer potential in breast cancer. 1 ...
(Date:5/28/2015)... Glenn Keet, CEO of Clinovo ... EMR/EHR Clinical Data Integration with EDC Systems ” at ... DC on June 14th-18th. , During the presentation, Glenn ... with EDC, and will examine the value of patient ... electronic health records/electronic medical records integration. , The ...
(Date:5/28/2015)... Rochelle, Virginia (PRWEB) May 28, 2015 ... Partners LLC announced today that Roger L. Williams, ... Expert consultant. NDA Partners Premier Experts are top ... them to bring extraordinary value to the company’s ... critical solutions to help clients successfully develop their ...
(Date:5/27/2015)... Mass. , May 27, 2015 ... biotechnology company focused on discovering and developing innovative ... ophthalmology, today announced that it has commenced a public ... to purchase shares of its common stock and ... common stock. The shares of common stock, warrants ...
Breaking Biology Technology:Data Presented At 2015 ASCO Annual Meeting Shows Biscayne Pharmaceuticals' GHRH Antagonist Target Is Expressed Across All Breast Cancer Subtypes 2Data Presented At 2015 ASCO Annual Meeting Shows Biscayne Pharmaceuticals' GHRH Antagonist Target Is Expressed Across All Breast Cancer Subtypes 3Clinovo Presents at the DIA 2015 51st Annual Meeting in Washington, DC on June 14th-18th 2Former CEO and Chair of the Council of Experts at the USP, Roger L. Williams, MD, Joins NDA Partners as a Premier Expert Consultant 2RXi Pharmaceuticals Announces Proposed Public Offering of Common Stock and Warrants 2RXi Pharmaceuticals Announces Proposed Public Offering of Common Stock and Warrants 3
... to Vice President and Chief Financial ... Transition to Consultant Role, SOUTH SAN FRANCISCO, ... ) today reported 2007 fourth quarter and year-end,financial ... 2008,based on commercialization plans for FDA-approved Zingo(TM) (lidocaine,hydrochloride ...
... Mass., Feb. 11 Millstone Medical,Outsourcing announced ... minimal,interruption after last week,s tornado by relocating ... Center address is 4740 Shelby,Drive, Memphis, TN, ... the,initial location, the new Millstone facility provides ...
... Data Presented at the 66th Annual Meeting of the American Academy ... ... clinical research from AGI,Dermatics indicates that L-Ergothioneine (EGT) and its natural receptor,OCTN- ... more,effective than idebenone in reducing harmful free radicals in photoaged,skin. The data ...
Cached Biology Technology:Anesiva Announces Fourth Quarter and Year-End 2007 Financial Results and Provides 2008 Outlook 2Anesiva Announces Fourth Quarter and Year-End 2007 Financial Results and Provides 2008 Outlook 3Anesiva Announces Fourth Quarter and Year-End 2007 Financial Results and Provides 2008 Outlook 4Anesiva Announces Fourth Quarter and Year-End 2007 Financial Results and Provides 2008 Outlook 5Anesiva Announces Fourth Quarter and Year-End 2007 Financial Results and Provides 2008 Outlook 6Anesiva Announces Fourth Quarter and Year-End 2007 Financial Results and Provides 2008 Outlook 7Anesiva Announces Fourth Quarter and Year-End 2007 Financial Results and Provides 2008 Outlook 8Anesiva Announces Fourth Quarter and Year-End 2007 Financial Results and Provides 2008 Outlook 9Millstone Medical Outsourcing Relocates Memphis Distribution Center Within 72 Hours of Tornado Disaster 2AGI Dermatics Clinical Data Identifies L-Ergothioneine as Part of Skin's Natural Antioxidant System 2
Request Info...
... is a nonspecific endonuclease that degrades double-and ... hydrolyzing phosphodiester linkages, producing mono and oligonucleotides ... Ambion's RNase-free DNase I is of the ... degrade DNA in the presence of RNA ...
hnRNP U (H-94)...
... GELase™ Agarose Gel-Digesting Preparation contains a unique ... simple, quantitative recovery of intact DNA and ... gels following electrophoresis in TAE, TBE, MOPS, ... digested directly in the TAE, TBE, MOPS, ...
Biology Products: