Navigation Links
Tiny clue reveals new path toward heart disease

e" where DNA variations appeared to be inherited along with the disease. They found just such a region: a small section of the long arm of chromosome 3 where just a handful of genes were located. Chromosome 3 is one of the 23 pairs of chromosomes that comprise the human genome.

In the current study, the researchers focused on specific gene variants, called single nucleotide polymorphisms (SNPs), that occur when a single nucleotide building block in the long strand of DNA is altered. The researchers sought SNPs that occurred more or less often in individuals with coronary artery disease than in individuals without it, as such a link would indicate that these gene variants were associated with the disease.

The researchers first obtained DNA from 500 patients who had volunteered to be studied while being examined at the cardiac catheterization laboratories at Duke University Hospital. Using these DNA samples, the researchers scanned the same small section of chromosome 3 for SNPs that differed in sequence between individuals with and without coronary heart disease.

One SNP, in the kalirin gene, varied between individuals with heart disease and those without. The researchers repeated the same experiment in four additional patient populations, scanning the DNA of a total of 4,000 individuals, and turned up the same result.

"This finding opens up a whole new area of study for looking at risks of cardiovascular disease," said senior study investigator Jeffrey M. Vance, M.D., Ph.D., director of the Center for Molecular Genetics and Genomic Medicine, Miami Institute for Human Genomics at the Miller School of Medicine.

The researchers are now studying kalirin in the blood vessels to see how variations in the gene contribute to cardiovascular disease.

So far, they have found that this particular SNP is significantly correlated with the degree of atherosclerosis in human aortas, the large blood vessel that brings b
'"/>

Source:Duke University Medical Center


Page: 1 2 3

Related biology news :

1. A bacterial genome reveals new targets to combat infectious disease
2. First real-time view of developing neurons reveals surprises, say Stanford researchers
3. Examination of internal wiring of yeast, worm, and fly reveals conserved circuits
4. NYU study reveals how brains immune system fights viral encephalitis
5. Study reveals new technique for fingerprinting environmental samples
6. Study reveals dramatic difference between breast cancers in US and Africa
7. UCSD research reveals mechanism involved with type of fatal epilepsy
8. Study reveals candidate targets for anti-retroviral therapeutics
9. Chimp genome reveals a retroviral invasion
10. Survey reveals women and doctors arent talking about HPV
11. Bioinformatics reveals new gene regulation system
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Tiny clue reveals new path toward heart disease

(Date:6/18/2013)... Arlington environmental engineer has been awarded a $394,300 ... ensure water quality and flow in the new ... Andrew Kruzic, UT Arlington associate professor of civil ... to add monochloramine to the water in an ... pump stations and pipelines. Adding monochloramine is widely ...
(Date:6/18/2013)... The National Institutes of Health has awarded $12.7 ... a selection of pharmaceutical industry compounds to explore ... including Alzheimer,s disease, Duchenne muscular dystrophy and schizophrenia. ... Uses for Existing Molecules, is led by the ... funded by the NIH Common Fund. , The ...
(Date:6/18/2013)... 10% of breast and ovarian cancers are familial in ... attributable to inherited mutations from the parents in genes ... mutations, PARP inhibitors, which are currently in clinical trials, ... option for personalised cancer treatment, an alternative to standard ... of these patients generate resistance to the drug and, ...
Breaking Biology News(10 mins):UT Arlington research to benefit quality, flow in 150-mile Integrated Pipeline 2NIH to fund collaborations with industry to identify new uses for existing compounds 2NIH to fund collaborations with industry to identify new uses for existing compounds 3NIH to fund collaborations with industry to identify new uses for existing compounds 4An article in 'Cell' reveals a new resistance mechanism to chemotherapy in breast and ovarian cancer 2
... The University of Miami,s Rosenstiel School of Marine and ... E.M. Rickaby, Ph.D., as recipient of the 2009 Rosenstiel ... Fellow of Wolfson College, Rickaby works in the Department ... current research on the interaction between marine phytoplankton and ...
... of years, green plants have employed photosynthesis to capture ... A goal of scientists has been to develop an ... produce liquid fuels from carbon dioxide and water. Researchers ... Laboratory (Berkeley Lab) have now taken a critical step ...
... the sea, and are responsible for providing nearly half of ... However, unlike their counterparts on land, the marine plants ... human sight. Consequently, we are still in a very ... phytoplankton biology and ecology. In a new paper published ...
Cached Biology News:Oxford's Dr. Rosalind Rickaby receives 2009 Rosenstiel Award 2Oxford's Dr. Rosalind Rickaby receives 2009 Rosenstiel Award 3Turning sunlight into liquid fuels 2Turning sunlight into liquid fuels 3A new view of oceanic phytoplankton 2A new view of oceanic phytoplankton 3
(Date:6/19/2013)... (PRWEB) June 19, 2013 India’s ... business can potentially be worth up to a ... opportunity, the Indian government is taking serious action ... the process. , This presentation will examine:, ... regulations ,     Immediate and long term impacts ...
(Date:6/19/2013)... Applied Rigaku Technologies, Inc. is pleased to publish ... sulfur in ultra-low sulfur diesel (ULSD) using the new ... . The analysis detailed in Rigaku Application Note 1272 ... International Standard specifies an energy dispersive X-ray fluorescence (EDXRF) ... automotive gasoline. , Regulations around the world have limited ...
(Date:6/19/2013)... A new look at “big glass” and visionary ... highlight technical sessions at SPIE Photomask Technology 2013 ... year, the three-day event is the industry’s largest mask ... 100 technical presentations and numerous networking lunches and receptions. ... and photonics , the meeting will be held at ...
(Date:6/19/2013)... Express Diagnostics Int’l, Inc., manufacturer of ... it has received Class III medical device license approval ... DrugCheck® NxStep Onsite Drug Screen Cup in Canada. ... device in near-patient settings, such as physicians’ offices. , ... Canada Class III approval for 24 different drugs and ...
Breaking Biology Technology:Rigaku Publishes New Application Note for Analysis of ULSD Per ISO 13032 2‘Big Glass’ and Visions for the Future are on the Program for SPIE Photomask Technology 2‘Big Glass’ and Visions for the Future are on the Program for SPIE Photomask Technology 3Express Diagnostics’ DrugCheck® On-site Test Cup Receives Health Canada Class III Medical Device Approval 2Express Diagnostics’ DrugCheck® On-site Test Cup Receives Health Canada Class III Medical Device Approval 3
... -- Huifeng Bio-,Pharmaceutical Technology, Inc (OTC Bulletin Board: ... and pharmaceutical raw materials,for use in pharmaceutical, nutraceutical ... financial results second quarter 2008 which,ended June 30 ... markets close., Huifeng,s earnings release and related ...
... 4 Neurobiological,Technologies, Inc. (NTI(R)) (Nasdaq: ... quarterly royalty payment of approximately $2.1 million ... Memantine for the treatment of,moderate-to-severe Alzheimer,s disease. ... quarterly royalty payments on certain,sales of Memantine ...
... announced partnership, Grid Dynamics and GridGain teamed up to develop the ... ... San Francisco, CA (PRWEB) August 4, 2008 -- Following ... up to develop the largest publicly known grid scalability test for ...
Cached Biology Technology:Grid Dynamics Demonstrates Linear Scalability up to 512 Nodes with GridGain Software on Amazon EC2 Cloud 2Grid Dynamics Demonstrates Linear Scalability up to 512 Nodes with GridGain Software on Amazon EC2 Cloud 3
Rad51, N-terminal...
Rabbit polyclonal to WWOX8 ( Abpromise for all tested applications). entrezGeneID: 51741 SwissProtID: Q9NZC7-8...
Goat polyclonal to T7 tag (Agarose) Immunogen: Goats were immunized with MASMTGGQQMG (T7) conjugated to KLH.After multiple immunizations in Freund's adjuvant, serum was collected....
Rabbit polyclonal to Olfactory Receptor LS189744 ( Abpromise for all tested applications)....
Biology Products: