Navigation Links
Tiny RNA molecules fine-tune the brain's synapses

Non-coding regions of the genome ?those that don't code for proteins ?are now known to include important elements that regulate gene activity. Among those elements are microRNAs, tiny, recently discovered RNA molecules that suppress gene expression.

Increasing evidence indicates a role for microRNAs in the developing nervous system, and researchers from Children's Hospital Boston now demonstrate that one microRNA affects the development of synapses ?the points of communication between brain cells that underlie learning and memory. The findings appear in the January 19th issue of Nature.

"This paper provides the first evidence that microRNAs have a role at the synapse, allowing for a new level of regulation of gene expression," says senior author Michael Greenberg, PhD, Director of Neuroscience at Children's Hospital Boston. "What we've found is a new mechanism for regulating brain function."

The brain's ability to form and refine synapses allows organisms to learn and respond to their environment, strengthening important synaptic connections, forming new ones, and allowing unimportant ones to weaken. Experiments in Greenberg's lab, done in rats, showed that a microRNA called miR-134 regulates the size of dendritic spines, the protrusions from a neuron's dendrites where synapses form. When neurons were exposed to miR-134, spine volume significantly decreased, weakening the synapse. When miR-134 was inhibited, spines increased in size, strengthening the synapse.

Further experiments showed that miR-134 acts by inhibiting expression of a gene called Limk1, which causes dendritic spines to grow. When neurons were exposed to a growth factor known as brain-derived neurotrophic factor (BDNF), this inhibition was overcome and Limk1 became active again, enhancing spine growth.

Greenberg believes that miR-134 ?and other microRNAs his lab is studying ?may play a role in fine-tuning cognitive function by selectively controlling synapse de
'"/>

Source:Children's Hospital Boston


Page: 1 2

Related biology news :

1. Inflammatory molecules released by pollen trigger allergies
2. Medical molecules designed to respond to visible light that can penetrate tissue
3. DNA constraints control structure of attached macromolecules
4. Scientists discover that three molecules may be developed into new Alzheimers drugs
5. Physical and functional interaction of key cell growth molecules linked to cancer
6. Scientists discover new way to look at how molecules twist and turn on water
7. Scientists learn to predict protein-stabilizing ability of small molecules
8. Convergent evolution of molecules in electric fish
9. Micro-boxes of water used to study single molecules
10. Researchers unveil strategy for creating actively-programmed anti-cancer molecules
11. Biological motors sort molecules one by one on a chip
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Tiny RNA molecules fine tune the brain synapses

(Date:7/31/2014)... marine noise can affect animal movement and communication, with ... and Exeter and the cole Pratique des Hautes tudes ... stops embryonic development and increases larval mortality in sea ... Stylocheilus striatus used in this study) usually hatch ... on toxic alga but this study, conducted in a ...
(Date:7/30/2014)... at New York University is paving the way ... in civilians and military troops exposed to poisonous ... , An article in the current issue of ... in detoxifying organophosphates, which are compounds commonly used ... was developed by NYU School of Engineering Associate ...
(Date:7/30/2014)... in Lewis Carroll,s Through the Looking Glass, collaborators ... of Singapore improved a 35-year-old ecology model to ... millions of years. , The new model, called ... "Red Queen Effect," an evolutionary hypothesis introduced by ... that organisms must constantly increase their fitness (or ...
Breaking Biology News(10 mins):Boat noise impacts development and survival of sea hares 2Engineering a protein to prevent brain damage from toxic agents 2Classic Lewis Carroll character inspires new ecological model 2Classic Lewis Carroll character inspires new ecological model 3
... likely impact of ocean acidification on shellfish and other marine ... is published this week (date) in the journal Global ... because some of the increased carbon dioxide humans are adding ... water to produce an acid. The results suggest that ...
... by the National Science Foundation (NSF) found state agency ... fiscal year 2009, a 7 percent increase over the ... details nationwide and state-by-state totals of R&D activities performed ... first time survey data are available by individual state ...
... release is available in German . Tomato ... with a genetic defect that made the fruits mature very slowly, ... were delighted as it gave them more time to transport the ... it would be sold. At the stores, the tomatoes could then ...
Cached Biology News:New study helps predict impact of ocean acidification on shellfish 2New study helps predict impact of ocean acidification on shellfish 3Ethylene of no effect -- why peppers do not mature after picking 2
(Date:7/31/2014)... July 31, 2014 The global market ... million by 2020, according to a new study by ... and theranostics, and the subsequent introduction of advanced cancer ... market growth over the next six years. Moreover, the ... such as cancer, coupled with disease triggering lifestyle habits ...
(Date:7/31/2014)... 31, 2014 SoundConnect , ... company, is proud to announce the addition of ... Adobe Connect’s elearning tools to quickly deploy and ... with training tools for desktop and mobile learning ... is the perfect online training solution, enabling organizations ...
(Date:7/30/2014)... July 30, 2014 Regulus Therapeutics Inc ... leading the discovery and development of innovative medicines targeting ... and highlights for the quarter ended June 30, 2014 ... markets close. Regulus will host a ... at 5:00 pm Eastern Daylight Time to discuss its ...
(Date:7/30/2014)... A study presented at the 2014 ... of CSL Behring,s C1 Inhibitor (C1-INH) concentrate in ... sensitized patients. C1-INH is a human protein and ... The study shows that post-transplant treatment with ... of complement components 3 and 4, suggesting that ...
Breaking Biology Technology:Molecular Diagnostics Market - Global Industry Size, Share, Trends, Analysis, Players, Opportunity, Outlook and Forecast From 2014 to 2020 2Molecular Diagnostics Market - Global Industry Size, Share, Trends, Analysis, Players, Opportunity, Outlook and Forecast From 2014 to 2020 3Molecular Diagnostics Market - Global Industry Size, Share, Trends, Analysis, Players, Opportunity, Outlook and Forecast From 2014 to 2020 4Molecular Diagnostics Market - Global Industry Size, Share, Trends, Analysis, Players, Opportunity, Outlook and Forecast From 2014 to 2020 5SoundConnect Enhances Portfolio with Adobe Connect Learning Management System (LMS) 2Regulus Announces Timing for Second Quarter 2014 Financial Results Webcast and Conference Call 2Regulus Announces Timing for Second Quarter 2014 Financial Results Webcast and Conference Call 3Study Suggests C1-INH May Aid in Prevention of Antibody-Mediated Rejection Following Kidney Transplant 2Study Suggests C1-INH May Aid in Prevention of Antibody-Mediated Rejection Following Kidney Transplant 3
... 1, 2011 Life Technologies Corporation (Nasdaq: ... webcasting management presentations to investors as part of the ... which is being held at the company,s headquarters in ...  Mark Stevenson, Life Technologies, President and Chief Operating Officer, ...
... NEW YORK, March 1, 2011 NeoStem, Inc. (NYSE Amex: ... in the U.S. and China, announced today that Dr. Robert ... Therapy ("PCT"), a wholly-owned subsidiary of NeoStem, Inc., has been ... 6th Annual New York Stem Cell Summit. The Summit will ...
... BioNeutral Group, Inc. (OTC Bulletin Board: ... announced that its wholly-owned subsidiary, BioNeutral Services, Inc., has ... (KEDFA) to receive up to $280,000 in development incentives ... February 24 meeting, six companies, including BioNeutral Services, Inc., ...
Cached Biology Technology:Life Technologies to Webcast Investor Presentation as Part of the UBS West Coast Life Sciences & Diagnostics Bus Trip 2Progenitor Cell Therapy to Present at 6th Annual New York Stem Cell Summit on Tuesday, March 1 2Progenitor Cell Therapy to Present at 6th Annual New York Stem Cell Summit on Tuesday, March 1 3Progenitor Cell Therapy to Present at 6th Annual New York Stem Cell Summit on Tuesday, March 1 4BioNeutral Group to Receive Economic Development Incentives 2BioNeutral Group to Receive Economic Development Incentives 3
... The Digital Clamp One can operate as ... as a Conductance (Dynamic) Clamp in electrophysiology research ... as good as conventional analog equipment. This ... advances in the capabilities of Digital Signal Processing ...
The new Silencer siRNA Starter Kit is perfect for researchers new to RNAi. It provides all of the reagents, protocols, and instructions necessary to get underway with siRNA transfection and ensure su...
... projects are focused on sequencing, analysis of ... other areas of genomics and proteomics, EvoQuest ... meet your research and manufacturing challenges. Invitrogen ... your project from beginning to end in ...
... Scale (gram quantities of IgY) , After we ... Antigen), we segregate the appropriate number of chickens ... such eggs are collected (usually over a period ... This involves a total of four injections into ...
Biology Products: