Navigation Links
Therapeutic role found for carbon monoxide

exposed these cultures to carbon monoxide, nothing happened. The cells behaved normally.

"We eventually asked ourselves, 'What if we're not seeing results in these two separate dishes because in the body, the two aren't separated. What if these two cell types somehow act in concert and need to communicate with one another as they otherwise would in vivo in order for CO to exert its beneficial effects?'"

To address this question, coauthor Beek Yoke Chin, PhD, developed a simulated blood vessel by growing the cells on a semi-permeable membrane, which enabled the two cell types to "communicate" with one another through pores. And that, says Otterbein, was when the scientists observed that in this "co-culture" setting, CO was able to induce death of the smooth muscle cells without adversely affecting the viability of the endothelial cells.

"We discovered that endothelial cells must be present ?and be able to generate NO via nitric oxide synthase [NOS3] -- in order for CO to induce the death of the smooth muscle cells and reverse the symptoms of PAH," explains Otterbein. To further test the role of the nitric oxide, the co-culture was treated with a select inhibitor of NOS3. Under these conditions, he adds, CO was unable to induce death to the same degree as in control-treated co-cultures.

"We concluded that the physical interaction between the two cell types plus the ability to generate NO was crucial for the positive CO effects," he says, adding that studies are now underway to determine the mechanism by which CO exposure leads to the increase in NO generation.

"Our hope is that CO will find a place in the clinic as a therapeutic option for the treatment of disease," concludes Otterbein. "CO has been around since before life began on earth and, in fact, it is thought to have contributed to the origin of life. Perhaps this was a sign of its necessary role in biology."


'"/>

Source:Beth Israel Deaconess Medical Center


Page: 1 2 3

Related biology news :

1. New Therapeutic Target Identified In Inherited Brain Tumor Disorder
2. Therapeutic prospects beyond Vioxx
3. New component of the brakes on nerve regeneration found
4. Strongest proof yet found for prion hypothesis
5. A puzzle piece found in unraveling the wiring of the brain
6. New World founders small in number
7. Norovirus found to cause travelers diarrhea
8. Pair of cancer genes found to drive both cell migration and division
9. Alien woodwasp, threat to US pine trees, found in N.Y.
10. Achilles heel of the herpes virus possibly found
11. Purdue scientists may have found key to halting spinal cord damage
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Therapeutic role found for carbon monoxide

(Date:9/18/2014)... will be celebrated tonight at the third annual Golden ... health of premature infants and in paving the way ... work was supported by the National Science Foundation, the ... Commission, will be honored at a ceremony at the ... of Members of Congress will be on hand to ...
(Date:9/18/2014)... Why is it that when people are too stressed ... Researchers from the Brain Mind Institute (BMI) at EPFL ... the relationship between chronic stress and the loss of ... an enzyme attacks a synaptic regulatory molecule in the ... Nature Communications . , Carmen Sandi,s team ...
(Date:9/18/2014)... Clownfish spend their entire lives nestling in the protective ... as babies they sometimes travel hundreds of kilometres across ... by reef fish has been predicted, this is the ... between distant populations has been observed. , Dr Steve ... at the University of Exeter, and colleagues from the ...
Breaking Biology News(10 mins):3rd annual Golden Goose award ceremony honors 8 researchers; Unusual work had big results 2How stress tears us apart 2Expedition finds Nemo can travel great distances to connect populations 2Expedition finds Nemo can travel great distances to connect populations 3
... cleanliness, have we permanently muddied our nation,s waters? ... in collaboration with federal partners,has completed the first statewide ... of the presence of active ingredients of personal care ... products are a billion dollar industry and can be ...
... those that can see inside single living cells are ... the body. NewYork-Presbyterian Hospital/Weill Cornell Medical Center,s Dr. ... bile ducts that connect the liver to the small intestine ... minutely explore the pancreatic duct as one of a few ...
... Scientists working with Professor Dr. Dr. Perikles Simon, head of ... in Germany, suggest in the light of recent analyses that ... birth up to the age of five years, today,s children,s ... ago. Then as now there are about 10 percent of ...
Cached Biology News:Antimicrobials from personal care products found in statewide survey of Minnesota's rivers and lakes 2Antimicrobials from personal care products found in statewide survey of Minnesota's rivers and lakes 3Antimicrobials from personal care products found in statewide survey of Minnesota's rivers and lakes 4Deep inside the body, tiny mechanical microscope 2Deep inside the body, tiny mechanical microscope 3When do German children gain weight? 2When do German children gain weight? 3
(Date:9/19/2014)... Florida , September 19, 2014 ... release latest developments, patents and results of studies and ... Eli Lilly and Company (NYSE: LLY ), ... Corporation (NASDAQ: CELG ) and Arena Pharmaceuticals ... a leader in developing prodrug therapeutics for the treatment ...
(Date:9/19/2014)... The new , Healthcare and Life Sciences Review ... PharmaBoardroom.com for free download , looks beyond ... economy in 2009, and the austerity measures that followed, to ... times of trouble. "Despite the crisis, ... and the general conditions to invest are favorable to the ...
(Date:9/18/2014)... A novel robotic system that can operate inside ... tested as part of a biomedical research partnership program ... aim of determining if the robot, in conjunction with ... more accurate, less costly, and less discomforting for the ... deliver prostate cancer therapies with greater precision. , Developed ...
(Date:9/18/2014)... Research and Markets has announced ... Cell Industry Report, 2014-2017" report to their offering. ... that can differentiate into specialized cells and can divide ... therapy can be applied to treatment of cardiovascular diseases, ... diseases, damage or lesion of liver, kidney and other ...
Breaking Biology Technology:Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 2Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 3Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 4Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 5Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 6Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 7PharmaBoardroom Releases New Spain Pharmaceuticals Report 2PharmaBoardroom Releases New Spain Pharmaceuticals Report 3Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 2Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 3Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 4Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 5Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 6Global and Chinese Stem Cell Industry Report, 2014-2017 2Global and Chinese Stem Cell Industry Report, 2014-2017 3
... 4 /PRNewswire-FirstCall/ - Oncolytics Biotech Inc. (TSX:ONC, NASDAQ: ... financial results for the year ended December 31, 2008. ... for REOLYSIN(R)," said Dr. Brad Thompson, President and CEO ... was supported by interim results reported in our US ...
... Medical,International Limited (NYSE: MR ), a ... announced today its selected unaudited,financial results for the ... 2008.,The financial results reported below include the results ... Datascope ("DPM") starting from May,1, 2008. , , ...
... over last year,s first , quarter , - Total ... of $15.4 million , - Earnings per share of $0.29, an ... , - New products launched containing life,sDHA(TM) in a variety of ... continue to demonstrate the strong , leverage in our ...
Cached Biology Technology:Oncolytics Biotech(R) Inc. Reports Highlights and Financial Results for 2008 2Oncolytics Biotech(R) Inc. Reports Highlights and Financial Results for 2008 3Oncolytics Biotech(R) Inc. Reports Highlights and Financial Results for 2008 4Oncolytics Biotech(R) Inc. Reports Highlights and Financial Results for 2008 5Oncolytics Biotech(R) Inc. Reports Highlights and Financial Results for 2008 6Oncolytics Biotech(R) Inc. Reports Highlights and Financial Results for 2008 7Oncolytics Biotech(R) Inc. Reports Highlights and Financial Results for 2008 8Oncolytics Biotech(R) Inc. Reports Highlights and Financial Results for 2008 9Mindray Announces 2008 Fourth Quarter and Full Year Results 2Mindray Announces 2008 Fourth Quarter and Full Year Results 3Mindray Announces 2008 Fourth Quarter and Full Year Results 4Mindray Announces 2008 Fourth Quarter and Full Year Results 5Mindray Announces 2008 Fourth Quarter and Full Year Results 6Mindray Announces 2008 Fourth Quarter and Full Year Results 7Mindray Announces 2008 Fourth Quarter and Full Year Results 8Mindray Announces 2008 Fourth Quarter and Full Year Results 9Mindray Announces 2008 Fourth Quarter and Full Year Results 10Mindray Announces 2008 Fourth Quarter and Full Year Results 11Mindray Announces 2008 Fourth Quarter and Full Year Results 12Mindray Announces 2008 Fourth Quarter and Full Year Results 13Mindray Announces 2008 Fourth Quarter and Full Year Results 14Mindray Announces 2008 Fourth Quarter and Full Year Results 15Mindray Announces 2008 Fourth Quarter and Full Year Results 16Mindray Announces 2008 Fourth Quarter and Full Year Results 17Mindray Announces 2008 Fourth Quarter and Full Year Results 18Mindray Announces 2008 Fourth Quarter and Full Year Results 19Martek Announces First Quarter 2009 Financial Results 2Martek Announces First Quarter 2009 Financial Results 3Martek Announces First Quarter 2009 Financial Results 4Martek Announces First Quarter 2009 Financial Results 5Martek Announces First Quarter 2009 Financial Results 6Martek Announces First Quarter 2009 Financial Results 7Martek Announces First Quarter 2009 Financial Results 8Martek Announces First Quarter 2009 Financial Results 9Martek Announces First Quarter 2009 Financial Results 10
... >95%NEN Radiolabeled Ligands\n\nReceptor-related research has long been ... radiolabeled ligands selected to keep pace with ... of products and services for receptor research ... radioligands. If you do not find exactly ...
... DNA polymerase is an antibody-mediated ... both conventional and real-time PCR ... at a concentration of 5 ... 5,000 units polymerase, 25 ml ...
... catalyzes the formation of a phosphodiester bonds ... nicked duplex DNA molecules or between oligonucleotides ... strand at 45 - 65?. Tfi DNA ... higher temperatures than conventional DNA ligases, Thus, ...
... contains a unique β-agarose digesting enzyme developed ... intact DNA and RNA from low melting ... TAE, TBE, MOPS, or phosphate buffers. The ... TAE, TBE, MOPS, and phosphate electrophoresis buffers ...
Biology Products: