Navigation Links
Therapeutic role found for carbon monoxide

In a medical case of Jekyll and Hyde, carbon monoxide ?the highly toxic gas emitted from auto exhausts and faulty heating systems ?has proven effective in treating the symptoms of pulmonary arterial hypertension (PAH), an extremely debilitating condition that typically leads to right heart failure and eventual death.

The new findings, made in an animal study led by researchers at Beth Israel Deaconess Medical Center (BIDMC) and the University of Pittsburgh, are described in the September 2006 issue of The Journal of Experimental Medicine (JEM).

The paradoxical theory that carbon monoxide (CO), the colorless, odorless gas often dubbed "the silent killer," could be used to prevent the onset of certain inflammatory conditions was first proposed in 1998. Since then, numerous studies have shown that when administered at low, non-toxic concentrations prior to such procedures as organ transplant surgery or balloon angioplasty, CO provides potent protective effects against organ rejection or blockage of the carotid arteries.

But, with these latest findings, explains senior author Leo Otterbein, PhD, it now appears that carbon monoxide can also be used to treat and reverse existing disease.

"Our results offer the exciting possibility that in extremely low concentrations and for brief intermittent exposures of one hour per day, CO gas might be effectively used as a therapy to treat PAH in a clinical setting," says Otterbein, an investigator in the Transplantation Center at BIDMC and Associate Professor of Surgery at Harvard Medical School.

Pulmonary arteries ?the blood vessels that carry blood from the heart's right ventricle to the small arteries in the lungs -- are made up primarily of endothelial cells and smooth muscle cells. PAH develops when, for unknown reasons, the smooth muscle cells rapidly and uncontrollably proliferate, leading to "remodeling," in which blood vessel walls thicken and gradual stenosis of the arteries occurs. U
'"/>

Source:Beth Israel Deaconess Medical Center


Page: 1 2 3

Related biology news :

1. New Therapeutic Target Identified In Inherited Brain Tumor Disorder
2. Therapeutic prospects beyond Vioxx
3. New component of the brakes on nerve regeneration found
4. Strongest proof yet found for prion hypothesis
5. A puzzle piece found in unraveling the wiring of the brain
6. New World founders small in number
7. Norovirus found to cause travelers diarrhea
8. Pair of cancer genes found to drive both cell migration and division
9. Alien woodwasp, threat to US pine trees, found in N.Y.
10. Achilles heel of the herpes virus possibly found
11. Purdue scientists may have found key to halting spinal cord damage
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Therapeutic role found for carbon monoxide

(Date:10/15/2014)... the 44th Rosenstiel Award for Distinguished Work in Biomedical ... the mechanisms of genomic instability and its implications for ... second alumnus to win the Rosenstiel Award; the first, ... Alt is the Charles A. Janeway Professor of Pediatrics ... an investigator at the Howard Hughes Medical Institute at ...
(Date:10/14/2014)... – Scientists have sequenced the house fly genome for ... might expect from an insect that thrives in pathogen-rich ... Oct. 14 in the journal Genome Biology , ... and of how flies quickly adapt to resist insecticides, ... house flies (Musca domestica) carry and transmit more than ...
(Date:10/14/2014)... of scientists led by researchers at the University ... of Miami Miller School of Medicine (UMMSM) have ... underlying bipolar (manic depressive) disorder, a breakthrough that ... affective disorder, as well as depression and other ... online this week in Nature Molecular Psychiatry ...
Breaking Biology News(10 mins):Brandeis awards 44th Rosenstiel Award to pioneering geneticist Fred Alt 2House fly genome reveals expanded immune system 2Rare genetic disease protects against bipolar disorder 2Rare genetic disease protects against bipolar disorder 3
... involved in many forms of leukemia and lymphoma is ... our genes by affecting whole swaths of chromosomes in ... issue of Nature Genetics and appearing online August 6. ... known as JAK/STAT focused on complex questions involving the ...
... Somerville of the Carnegie Institution and Stanford University, explained ... and achievable to reduce costs and multiply current levels ... Somerville presented his talk, "Bioenergy: The 21st Century Challenge ... American Society of Plant Biologists (ASPB) today (4:30 p.m. ...
... is a particular place inside a cell where they carry ... from the Charité Berlin, the University of Heidelberg, and the ... been able to visualize the structure of a "molecular machine" ... analysis. , This "machine" is made up of a ...
Cached Biology News:Loosen up, DNA: Leukemia gene changes genetic packaging 2Loosen up, DNA: Leukemia gene changes genetic packaging 3Loosen up, DNA: Leukemia gene changes genetic packaging 4Scientific issues associated with carbon-neutral energy sources such as cellulosic ethanol 2The molecular post office inside the cell 2
(Date:10/20/2014)... , A major pan-European survey ... delivery of care has revealed changing trends in many ... the provision of healthcare services across the continent. The ... European Gastroenterology (UEG), have been announced today and led ... the burden of GI disorders across Europe ...
(Date:10/20/2014)... PLAINSBORO, N.J. (PRWEB) October 20, 2014 ... that the Sidney Kimmel Cancer Center at Thomas ... program. , Through the Strategic Alliance Partnership ... and OncLive will collaborate to raise awareness of ... cancer treatment, and other projects. Clinicians and other ...
(Date:10/19/2014)... The Latin American hardware encryption display market ... with analysis and forecast of revenue. This market was ... to reach $2,366.8 million by 2018, at a CAGR ... the TOC of the Latin American hardware encryption market ... provided. It also provides a glimpse of the segmentation ...
(Date:10/19/2014)... October 19, 2014 The Asia-Pacific ... market in Asia-Pacific with analysis and forecast of ... Asia Pacific Bromine Market report, to get an ... provides a glimpse of the segmentation in the ... tables and figures. , http://www.micromarketmonitor.com/market/asia-pacific-bromine-6741503144.html ...
Breaking Biology Technology:Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 2Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 3Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 4Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 5Sidney Kimmel Cancer Center at Thomas Jefferson University Partners With OncLive 2Sidney Kimmel Cancer Center at Thomas Jefferson University Partners With OncLive 3The Latin American hardware encryption display market is expected to reach $2,366.8 million by 2018 - New Report by MicroMarket Monitor 2The Latin American hardware encryption display market is expected to reach $2,366.8 million by 2018 - New Report by MicroMarket Monitor 3The Asia-Pacific Bromine Market is estimated to grow to $4,080.1 million by 2018 - New Report by MicroMarket Monitor 2The Asia-Pacific Bromine Market is estimated to grow to $4,080.1 million by 2018 - New Report by MicroMarket Monitor 3
... BEIJING, Sept. 8 /PRNewswire-Asia/ -- Sinovac Biotech Ltd.,(NYSE Amex: ... China, today announced,that the first lot of PANFLU.1, its H1N1 ... for the Control of Pharmaceutical and,Biological Products and obtained the ... vaccines are ready for delivery. , ...
... SANTA CLARA, Calif., Sept. 8 Cell Biosciences, ... announced that they have entered into a definitive agreement providing ... $1.50 per share or approximately $17.9 million in cash. This ... include a global infrastructure and a broad protein analysis product ...
... LAIYANG, China, Sept. 8 /PRNewswire-Asia-FirstCall/ -- Jiangbo,Pharmaceuticals, Inc. (OTC ... with its principal operations in the People,s,Republic of China, ... The Company expects to meet or exceed its ... income of $40 to $43 million for the,fiscal year ...
Cached Biology Technology:Sinovac Obtains Lot Release Certificate for Its First Batch of H1N1 Vaccine 2Cell Biosciences Signs Agreement to Acquire Alpha Innotech 2Cell Biosciences Signs Agreement to Acquire Alpha Innotech 3Cell Biosciences Signs Agreement to Acquire Alpha Innotech 4Cell Biosciences Signs Agreement to Acquire Alpha Innotech 5Jiangbo Pharmaceuticals Reaffirms Guidance for Fiscal 2009 2
... is a 16 amino acid (amino acids 3-18) synthetic peptide ... The sequence of this peptide is (amino to carboxy terminus): ... V - K - L - R - A - ... K(18). This peptide may be used for neutralization ...
... standard microarray image analysis software because of ... tools, visualizations, automation capabilities, performance and ease ... every GenePix scanner, and it also imports ... types of arrays. A wide range of ...
... Package Superior Protein Detection and Quantitation ... 2D Proteomic Imaging System is a highly ... general life science research applications. ProXPRESS 2D ... all dyes in the UV and VIS ...
... Description: ,Kit containing Dermal Fibroblasts ... containing 20% FBS and 10% DMSO at ... mL) of optimized medium.This cell culture is ... guaranteed to provide an additional 6 months ...
Biology Products: