( emia cells. Chiorazzi and his team calc...)The very unexpected life and death of a leukemic cell

emia cells. Chiorazzi and his team calculated birth and death rates of the leukemic cells and found that, contrary to expectations, production and destruction of CLL cells is highly variable, and does not exhibit a steady birth and death rate as previously thought.

The data also reveal that a correlation exists between the rate at which CLL cells are born and the clinical activity or progression of the disease in a patient. The disease activity may vary over time and this may be the result of fluctuations in birth and/or death rates of the CLL cells.

This challenges the dogma that CLL is a purely accumulative disorder where leukemic cells accumulate because they cannot die. Clearly CLL is a disease in which there is a dynamic interplay between rates of cell division and cell death. The data could enable physicians to predict disease progression.

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In vivo measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia B cells

View the PDF of this article at: https://www.the-jci.org/press/23409.pdf

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Source:JCI


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