Navigation Links
The very unexpected life and death of a leukemic cell

B cell chronic lymphocytic leukemia (CLL) is an incurable disease in which cells in the bone marrow grow and survive to the point where they become abnormal and malignant (leukemic). The progression of the disease is slow and there has been a lack of information regarding the rate of production of CLL cells, and the time-course of their death.

For years, doctors and scientists believed that CLL was a static disease of long-lived lymphocytes -- that the leukemia cells were both immortal and born at a slow rate, causing the slow rise in cell count over time. But researchers had been unable to find any problems with the programmed cell death machinery in CLL cells. This was a hint that perhaps the leukemia cells were not immortal, a hypothesis tested by Nicholas Chiorazzi and colleagues in a paper appearing online on February 10 in advance of publication in the March 1 print edition of the Journal of Clinical Investigation. This new study shows that leukemia cells are born at a fast rate and do indeed die. The slow rise in the cell count over time can be attributed to the difference between the birth and death rates of the cells, according to the study.

The researchers at the Institute for Medical Research at North Shore-LIJ analyzed the kinetics of CLL cells in vivo by employing a non-radioactive labeling technique ?using "heavy water" to track cell production. Heavy water is made using a form of hydrogen that has twice its normal mass, making the water molecule "heavier" than normal. The special hydrogen serves as a tag that enables researchers to track the utilization of water in the body. The hydrogen incorporates into glucose and the tagged glucose eventually makes its way into the cell's DNA.

Researchers gave 19 individuals with CLL a small dose of heavy water every day for 84 days, and the tagged water was incorporated into the DNA of the leukemia cells. This provided the researchers a way to track the cell division, or "birth" of new leuk
'"/>

Source:JCI


Page: 1 2

Related biology news :

1. Retina adapts to seek the unexpected, ignore the commonplace
2. UF scientist finds unexpected link between cat and human AIDS viruses
3. Enzyme crystal structure reveals unexpected genome repair functions
4. Combination therapy boosts effectiveness of telomere-directed cancer cell death
5. Enzyme allows B cells to resist death, leading to leukemia
6. Critical role in programmed cell death identified
7. A comprehensive response to HIV could prevent 10 million AIDS deaths in Africa by 2020
8. The death of a very special chimpanzee
9. Solutions that reduce death of marine life reeled in by International Smart Gear Competition
10. Emergence of cancer as major cause of childhood death in developing countries is not being adequately addressed
11. Hanging baskets of sex and death help fruit growers
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: The very unexpected life and death leukemic cell

(Date:4/22/2014)... research projects study the effects of temperature and precipitation ... However, an important component of climate research, the UV-B ... in collaboration with their colleagues from the Universities in ... from the U.S. NASA space agency in such a ... influence of UV-B radiation on organisms. , The basic ...
(Date:4/22/2014)... another way of asking him or her to behave ... cells of the immune system tend to misbehave with ... these cells are known to misbehave similarly during spaceflight, ... cells to better understand how our immune systems change ... on Aging, part of the National Institutes of Health, ...
(Date:4/22/2014)... Recent projects in two Minnesota cities demonstrate how ... projects continue a ten year program in New ... plans tailored to local conditions. , "Our goal ... protect themselves," said program co-leader Latham Stack, of ... have already worsened. We help communities move beyond ...
Breaking Biology News(10 mins):UV-radiation data to help ecological research 2For an immune cell, microgravity mimics aging 2For an immune cell, microgravity mimics aging 3For an immune cell, microgravity mimics aging 4For an immune cell, microgravity mimics aging 5Minnesota projects offer hope and practical help to communities facing more extreme storms 2
... the journal Clinical Cancer Research, a journal ... non-invasive screening method with future potential for detection of ... In the study, researchers at Johns Hopkins University used ... identify oral HPV infections in patients with HPV16-positive and ...
... one in the United States and one in Australia, ... visualizing the invisible processes at work in several human ... the Optical Society,s (OSA) Interactive Science Publishing (ISP) initiative, ... large three-dimensional data and gives researchers, scientists and engineers ...
... 29, 2008 -- Vitamin E has been heralded for its ... and sudden death. Yet in some people, vitamin E causes ... excess vitamin E promotes bleeding by interfering with vitamin K, ... able to pinpoint how the two vitamins interact. Nutrition researcher ...
Cached Biology News:Oral rinses used for tracking HPV-positive head and neck cancers holds promise for cancer screening 2OSA's ISP launches with research on breathing disorders and congenital heart defects 2OSA's ISP launches with research on breathing disorders and congenital heart defects 3OSA's ISP launches with research on breathing disorders and congenital heart defects 4
(Date:1/15/2014)... Sunnyvale, CA (PRWEB) January 15, 2014 ... throughput research solutions, today announced that Lupin Limited, one ... of Freeslate’s CM Protégé PharmD System for ... in Mumbai, India, is focused on a wide range ...
(Date:1/14/2014)... San Diego, CA (PRWEB) January 14, 2014 ... based on the products of cells grown under simulated ... an international license agreement with Suneva Medical, Inc. for ... media (CCM). , This agreement is an ...
(Date:1/14/2014)... BETHESDA, Md. , Jan. 14, 2014  Organovo ... institutes from the National Institutes of Health (NIH) to ... more effective treatments to patients on a faster timeline. ... Translational Sciences (NCATS) and the National Eye Institute (NEI) ...
(Date:1/14/2014)... Ontario , Jan. 14, 2014   Kinaxis ®, provider ... SCM ) and sales and operations planning ( S&OP ) ... Biomanufacturing Summit , which will be held at the ... the conference, join Kinaxis customer Elisabeth Kaszas , Director ...
Breaking Biology Technology:Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 2Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 3Organovo Announces Collaboration with National Institutes of Health 2Organovo Announces Collaboration with National Institutes of Health 3Event Alert: Kinaxis Customer to Present at the Biomanufacturing Summit "Supply Chain: Improving Network Effectiveness" 2
... YORK, June 8, 2011 Reportlinker.com announces ... available in its catalogue: ... http://www.reportlinker.com/p0548785/Future-of-White-Biotechnology-in-China.html?utm_source=prnewswire&utm_medium=pr&utm_campaign=NoCategory ... referred to the third wave in biotechnology, ...
... 7, 2011 Vaxart, Inc., a San Francisco biotechnology company ... I clinical trial. This is the first clinical study evaluating ... The trial site is in the United States. ... is demonstrated with one vaccine, we can expect that later ...
... 7, 2011 Infrared Systems International (OTCBB: IFRS) is pleased ... pilot study of its NatuRx™ HIV/AIDS treatment and will push ... AquaLiv concluded a pilot study with two HIV/AIDS patients ... of the first reported AIDS victims on June 5th, 1981. ...
Cached Biology Technology:Reportlinker Adds Future of White Biotechnology in China 2Reportlinker Adds Future of White Biotechnology in China 3Reportlinker Adds Future of White Biotechnology in China 4Reportlinker Adds Future of White Biotechnology in China 5Vaxart Begins First Oral Vaccine Clinical Trial 2Infrared Systems International's Subsidiary, AquaLiv, Inc., Strives to Be a Game Changer in Fight Against HIV/AIDS 2Infrared Systems International's Subsidiary, AquaLiv, Inc., Strives to Be a Game Changer in Fight Against HIV/AIDS 3
These 25x25 square No.1 Corning cover glasses are made from No. 0211 zinc titania glass and are 0.16 to 0.19mm thick. • Approx. Pcs Oz : 102...
... of Cell Cultures (ECACC) has been offering ... and government institutes for over seven years. ... to introduce candidates to cell culture and ... more specialist areas such as planning and ...
...
These 22x40mm rectangular No.1 Corning cover glasses are made from No. 0211 zinc titania glass and are 0.16 to 0.19mm thick. • Approx. Pcs Oz : 73...
Biology Products: