Navigation Links
The very defensive caterpillar

Caterpillars are bleeding defensive! Insects are known to lack an antibody-mediated immune response, and research in caterpillars has recently shown that, instead, they produce protective proteins in response to bacterial infection. The pattern recognition receptors (PRR) and antibacterial effectors produced at a first infection still function to protect against a repeated challenge. These results raise important issues in insect research which will be reported by Dr. Ioannis Eleftherianos at the Society of Experimental Biology Annual Meeting at the Universitat Autonoma de Barcelona on Wednesday 13th of July.

After being fed on a diet of antibiotics, hawkmoth (Manduca sexta) caterpillars were infected by non-pathogenic bacteria (E. coli), followed by exposure to a second, but lethal insect pathogen (Photorhabdus). Investigation of their blood then showed that antibacterial peptides were being produced by the so-called 'fat-body', an organ specialised in protein production. These proteins appear to be able to persist from the initial benign E. coli infection and then confer resistance against the second, usually lethal, infection by the pathogen. Using RNAi techniques workers at the University of Bath have shown that several different proteins can confer this protective effect against subsequent infections.

Micro-organisms such as bacteria, fungi and nematodes are often used as biocontrol agents against insects. It had always been assumed that insects in the field would be naïve to such control agents but these results raise the possibility that control with one pathogen may confer resistance to another. Most experiments on insect immunity are conducted in the laboratory on insects often fed on antibiotic containing diet so these results suggest that the immune response of insect constantly exposed to pathogens in the field may be very different from all the work described in the laboratory. This raises new challenges for the field and places into ques tion the relevance of laboratory based studies on immunity.


'"/>

Source:Society for Experimental Biology


Related biology news :

1. Nonvenomous Asian snakes borrow defensive poison from toxic toads
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/5/2018)... Tenn. (PRWEB) , ... December 05, 2018 , ... ... at the Annual AANS/CNS Summit in Nashville, TN, from December 6-9, 2018 at ... Virtual Reality platform that seamlessly integrates throughout the treatment continuum – from the ...
(Date:12/5/2018)... ... 2018 , ... Slone Partners, North America’s leading executive search ... at Karius, Inc. as Chief Commercial Officer. Now responsible for developing, executing, and ... in Redwood City, California and report to CEO Mickey Kertesz Ph.D. , ...
(Date:12/5/2018)... DIEGO (PRWEB) , ... December 04, 2018 , ... ... leverage Fastec’s extensive expertise and existing IP in the development of innovative solutions ... has been integrated into diverse systems from microfluidics to industrial machinery and instrumentation, ...
Breaking Biology News(10 mins):
(Date:11/13/2018)... ... 13, 2018 , ... Aditya Humad, Managing Partner of ... asserts it is still trending upward with growing valuations based on a largely ... consolidation, pricing pressure and increased competition as reasons often cited by institutional investors ...
(Date:11/11/2018)... ... ... Triple W, an innovator of connected health devices, today announced that it ... ®, the first health tech wearable device for incontinence that monitors how full your ... announcement was made during CES Unveiled New York, an invite-only tech event bringing together ...
(Date:11/9/2018)... ... November 08, 2018 , ... Superior ... and IT solutions with 140 employees on both the east and west coasts, ... the Pennsylvania Convention Center on November 14 and 15 in Philadelphia. The event ...
(Date:11/6/2018)... ... November 06, 2018 , ... ... for clinical trial data collection and management. TrialKit ™, an eClinical platform, ... generation devices can quickly and easily sign in to the app via facial ...
Breaking Biology Technology: