Navigation Links
The sturdier sex? -- Study by Pittsburgh scientists finds female stem cells work better

Female stem cells derived from muscle have a greater ability to regenerate skeletal muscle tissue than male cells, according to a study at Children’s Hospital of Pittsburgh of UPMC.

The study, which is being published in the April 9 issue of the Journal of Cell Biology, is the first ever to report a difference in regenerative capabilities of muscle stem cells based on sex.

This finding could have a major impact on the successful development of stem cells as viable therapies for a variety of diseases and conditions, according to the study’s senior author, Johnny Huard, PhD, director of the Stem Cell Research Center at Children’s and the Henry J. Mankin Professor and Vice Chair for Research in the Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine.

"Regardless of the sex of the host, the implantation of female stem cells led to significantly better skeletal muscle regeneration," said Dr. Huard, also the deputy director of the McGowan Institute of Regenerative Medicine. "Based on these results, future studies investigating regenerative medicine should consider the sex of the stem cells to be an important factor. Furthermore, investigations such as ours could lead to a better understanding of sex-related differences in aging and disease and could explain, at least partially, the high variability and conflicting results reported in the literature on stem cell biology."

Dr. Huard’s team, and the study’s first author, Bridget Deasy, PhD, director of the Live Cell Imaging Lab at Children’s Stem Cell Research Center, made the discovery while working with a population of stem cells they isolated in the lab while searching for a cure for Duchene muscular dystrophy (DMD). DMD is a genetic disease estimated to affect one in every 3,500 boys. Patients with DMD lack dystrophin, a protein that gives muscle cells structure. Using an animal model of the disease, his laboratory is using stem cells to deliver dystrophin t
'"/>

Source:Children's Hospital of Pittsburgh


Page: 1 2

Related biology news :

1. Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down
2. Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs
3. UCLA Study Shows One-Third of Drug Ads in Medical Journals Do Not Contain References Supporting Medical Claims
4. Study Demonstrates Gene Expression Microarrays are Comparable and Reproducible
5. Study Links Ebola Outbreaks To Animal Carcasses
6. Breakthrough Microarray-based Technology for the Study of Cancer
7. NYU Study Reveals How Brains Immune System Fights Viral Encephalitis
8. Study finds more than one-third of human genome regulated by RNA
9. Leukemia Drug Breakthrough Study In New England Journal Of Medicine
10. Study identifies predictors of HIV drug resistance in patients beginning triple therapy
11. New Study from Affymetrix Laboratories Points to Changing View of How Genome Works
Post Your Comments:
(Date:10/27/2014)... Ga. – Multiple times each day, about a third ... pressure – for at least an hour after the ... , Now they want to know how chronic mental ... response so they can determine the best ways to ... sodium is bad for you – these patients have ...
(Date:10/27/2014)... — Recent breakthroughs may pave the way for ... parasitic helminths. These flatworms, including tapeworms that cause ... flukes (schistosomes), infect more than 300 million people ... lost due to chronic illness and death each ... of microbiology, immunology, and tropical medicine, and scientific ...
(Date:10/27/2014)... /CNW/ - A robust contingent of Canadian researchers will present ... (HIV R4P) Conference in Cape Town, South Africa ... Oct. 28 to 31 is expected to attract up to ... HIV R4P is the world,s first and only scientific meeting ... Twenty nine oral and poster presentations will be made by ...
Breaking Biology News(10 mins):Researchers look for the best way to help shake too much sodium 2Researchers look for the best way to help shake too much sodium 3Researchers look for the best way to help shake too much sodium 4GW researcher adapting breakthrough technologies to combat parasitic worm infections 2Canadian Research Well Represented at HIV Prevention Conference 2
... their offspring so they inherit either their mother,s or ... offspring are more likely to have daughters. Weaker ... produce more sons. The study, by scientists at ... University (Japan), is published today (9 January) in the ...
... effect on alpine vegetation than at first anticipated, according to ... and published in Nature Climate Change . The first ... some alpine meadows could disappear within the next few decades. ... Sciences and the University of Vienna, biologists from 13 different ...
... warmest since global climate has been measured, and while ... plant communities that reflect this warming trend, no study ... until now. With the publication of "Continent-wide ... Advance Online Publication (AOP) in Nature Climate Change ...
Cached Biology News:Fit females make more daughters, mighty males get grandsons 2Climate change is altering mountain vegetation at large scale 2European mountain vegetation shows effects of warmer climate 2
(Date:10/30/2014)... October 30, 2014 Investor-Edge has ... (NYSE MKT: ONVO), Medivation Inc. (NASDAQ: MDVN ... Biologics Inc. (NYSE MKT: SYN), and Ironwood Pharmaceuticals Inc. ... be accessed at: http://investor-edge.com/register . On ... 4,549.23, down 0.33%, the Dow Jones Industrial Average declined ...
(Date:10/30/2014)... (PRWEB) October 29, 2014 Global polyvinyl ... the world economic crisis during 2008-2009, especially in North ... recovered and currently is keeping to a growing trend. ... volume is utilized in the construction segment. In 2013, ... pipes, profiles, tubing, sheets and rigid film. Moreover, the ...
(Date:10/30/2014)... On October 26th at the ... Chicago, leading applied stem cell research scientist Neil ... presented talks on New Techniques for Enhancing Stem ... Stem Cells. , Dr. Riordan focused on historical ... of AlphaGEMS that include: wound healing; inflammation and ...
(Date:10/30/2014)... Diego, CA (PRWEB) October 30, 2014 ... announced today that they have manually curated public data ... and non profit customers. the data is now ... manually curates and unifies public and internal data sources ... value and knowledge out of the data that becomes ...
Breaking Biology Technology:Biotech Equities Movers and Shakers - Organovo Holdings, Medivation, Pharmacyclics, Synthetic Biologics, and Ironwood Pharma 2Biotech Equities Movers and Shakers - Organovo Holdings, Medivation, Pharmacyclics, Synthetic Biologics, and Ironwood Pharma 3Biotech Equities Movers and Shakers - Organovo Holdings, Medivation, Pharmacyclics, Synthetic Biologics, and Ironwood Pharma 4Biotech Equities Movers and Shakers - Organovo Holdings, Medivation, Pharmacyclics, Synthetic Biologics, and Ironwood Pharma 5Global Polyvinyl Chloride Demand Is on Upward Trend Now, Says Merchant Research & Consulting in Its Topical Study 2Global Polyvinyl Chloride Demand Is on Upward Trend Now, Says Merchant Research & Consulting in Its Topical Study 3Riordan-McKenna Institute Founders, Neil Riordan, PhD and Orthopedic Surgeon, Dr. Wade McKenna Present at the Mid American Regenerative and Cellular Medicine Showcase 2Riordan-McKenna Institute Founders, Neil Riordan, PhD and Orthopedic Surgeon, Dr. Wade McKenna Present at the Mid American Regenerative and Cellular Medicine Showcase 3Riordan-McKenna Institute Founders, Neil Riordan, PhD and Orthopedic Surgeon, Dr. Wade McKenna Present at the Mid American Regenerative and Cellular Medicine Showcase 4Rancho BioSciences Manually Curated TCGA Data Sets Available 2
... 2011 SeraCare Life Sciences, Inc. (NASDAQ: ... products and services to facilitate the discovery, development and ... election of Joseph Nemmers and Kevin Hrusovsky to its ... has been appointed to the position of Chairman of ...
... 2011 OncoSec Medical Inc. (OTCBB: ONCS), a ... treat solid tumor cancers that have unmet medical ... to its leadership team. Formed earlier this year, ... for its tumor-destroying, tissue-sparing ElectroOncology therapies before the ...
... a one-atom thick sheet of carbon atoms arranged ... that has taken scientific communities and industrial sectors ... such as high current-carrying capacity and thermal conductivity, ... semiconductor circuits and computers. Moreover, it enables table-top ...
Cached Biology Technology:SeraCare Announces the Election of Joseph Nemmers and Kevin Hrusovsky to the Board of Directors 2SeraCare Announces the Election of Joseph Nemmers and Kevin Hrusovsky to the Board of Directors 3SeraCare Announces the Election of Joseph Nemmers and Kevin Hrusovsky to the Board of Directors 4OncoSec Announces Leadership Team Appointments 2OncoSec Announces Leadership Team Appointments 3OncoSec Announces Leadership Team Appointments 4Why graphene holds the key to the future 2
The pCDF Expression System 1 plus Competent Cells contains 10 µg of pET-45b(+) DNA. pET-45b carries an N-terminal His•Tag ® coding sequence that is cleavable with enterokinase as well...
Nucleobindin 1 [NUCB1]...
Request Info...
... cells (HSC) are well-characterized tissue-specific stem cells ... responsible for the life-long maintenance of the ... reside in adult bone marrow where hematopoiesis ... be found in cord blood, fetal liver, ...
Biology Products: