Navigation Links
The power of one: A simpler, cheaper method for cell fusion

ricity from one pole to the other. Passing through this narrow section, cells are subjected to a strong electrical field that causes them to become destabilized and fuse together.

In one of electrofusion's applications, scientists can fuse antibody-producing cells from the spleen (beta cells) with cancer cells in order to create a virtually immortal, antibody-producing hybrid, called a hybridoma. By manipulating the beta cells prior to fusion, scientists can create thousands of different hybridomas that produce antibodies effective against different viruses and diseases like cancer.

Lu's research regarding the development and use of this technology was published online Monday (Dec. 4) in the journal Applied Physics Letters and is scheduled to appear in print later this month. Graduate student Jun Wang was a co-author.

One downside to the current technique for electrofusion is that researchers have relatively little control over how many cells they fuse at once; the technique works by aligning an uncertain number of cells along an electrical field before zapping them with pulses of electricity. Lu's technology is more precise.

"In my device, the narrow section in the microfluidic channel is so small that only two to three cells fit into it," Lu said.

Lu said he believes that his device may be developed to have a higher throughput than current methods. Although Lu's technology currently fuses single pairs at once, it may be expanded so that multiple devices simultaneously fuse cells in parallel.

"In time, this could drastically increase the rate of cell fusion," he said.

Lu has shown that his technology has a success rate comparable to current technology; about 30 percent to 40 percent of the cells are properly fused when the operational parameters were tuned up.

"We are not saying that our technology is necessarily better, but it is definitely cheaper and has other benefits," he said. "Ho
'"/>

Source:Purdue University


Page: 1 2 3

Related biology news :

1. Scientists Propose Sweeping Changes to Naming of Bird Neurosystems to Acknowledge Their True Brainpower
2. New drug shows promise as powerful anticancer agent
3. The evolutionary triumph of flower power
4. Researchers find promising cancer-fighting power of synthetic cell-signaling molecule
5. High-powered gene profiles provide clues to genes involved in common form of lung cancer
6. Mosaic mouse technique offers a powerful new tool to study diseases and genetics
7. Its electric: Cows show promise as powerplants
8. Lance Armstrong through a physiological lens: hard training boosts muscle power 8%
9. Researchers find ways to turn manure into power
10. License to kill enables powerful immune attack cells in mice
11. Nanoparticles, nanoshells, nanotubes: How tiny specks may provide powerful tools against cancer
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: The power one simpler cheaper method for cell fusion

(Date:9/15/2014)... Earth for the first 500 million years after it ... day, complete with oceans, continents and active crustal plates. ... called the Hadean, has gained substantial new support from ... more than 4 billion years ago with those formed ... possible geological analog for early Earth. , The study ...
(Date:9/15/2014)... cognitive function may play roles in one,s musical aptitude, ... timbre, tone durations, and formal structure in music. , ... that extremes in musical aptitude (extreme capacity/no capacity) are ... having moderate aptitude. , "This is a typical feature ... and it is influenced to varying degrees by environmental ...
(Date:9/15/2014)... from GEOMAR Helmholtz Centre for Ocean Research Kiel ... demonstrated for the first time, that the single ... Emiliania huxleyi , can adapt simultaneously to ... study, the researchers found no evidence for the ... aspects of climate change would interfere with each ...
Breaking Biology News(10 mins):Early Earth less hellish than previously thought 2Early Earth less hellish than previously thought 3Small algae with great potential 2Small algae with great potential 3
... 2013) As public health authorities across the globe grapple ... of Medicine microbiologists and colleagues have identified the unique resistance ... resistant to carbapenems. Carbapenems are a class of antibiotics ... bacteria, including E. coli and Klebsiella pneumonia ...
... of poultry could be improved by a discovery about how ... chicken,s genetic make-up can affect the signals sent from its ... has had enough to eat. Poultry farmers often have ... to feelings of fullness and can overeat, affecting their ability ...
... , March 26, 2013 Today, Hyland ... Intelligence Corporation (CIC; OTCQB: CICI), a leading ... help organizations automate processes, such as electronic mortgage ... enterprise content management (ECM) solution, OnBase, with ...
Cached Biology News:New study identifies unique mechanisms of antibiotic resistance 2Appetite genes are key to better diets for poultry, study shows 2Hyland Software Partners with Communication Intelligence Corporation (CIC), a Leading Supplier of Electronic Signature Solutions 2Hyland Software Partners with Communication Intelligence Corporation (CIC), a Leading Supplier of Electronic Signature Solutions 3
(Date:9/16/2014)... 16, 2014 According to Jeff Howell, ... of ITRA Global, new development in Downtown Toronto is ... council approving another 755 storeys of new development last ... cranes will be dominating the Toronto skyline for the ... an unquenchable thirst for new development. , As the ...
(Date:9/15/2014)... 15, 2014 EnGeneIC, Ltd. , ... treatment of cancer through the targeted delivery of ... together with the Asbestos Disease Research Institute (ADRI), ... South Wales (NSW) Premier,s Award for Excellence in ... the hospitals that will be involved in the ...
(Date:9/15/2014)... Northeastern University has developed a novel method for ... of nanocarbon structures in carbon nanotube arrays. The ... allow the researchers to tailor the physical properties ... from electronic devices to CNT-reinforced composite materials found ... Their findings were published in the journal ...
(Date:9/15/2014)... The chemistry, taste, and health effects of tea ... published by the nonprofit American Botanical Council (ABC). Recent research ... its effects on the phytochemical compounds in tea ( Camellia ... Dr. Ahmed in the Yunnan province ... for the future of medicinal botanicals. Dr. Ahmed,s report ...
Breaking Biology Technology:ITRA Global Reports Downtown Toronto Real Estate Development is in High Gear 2ITRA Global Reports Downtown Toronto Real Estate Development is in High Gear 3EnGeneIC Named a Recipient of the Cancer Institute NSW Premier's Award for Excellence in Translational Cancer Research 2EnGeneIC Named a Recipient of the Cancer Institute NSW Premier's Award for Excellence in Translational Cancer Research 3Northeastern University Researchers Develop Novel Method for Working with Nanotubes 2Tea Taste and Quality Affected by Climate Change 2Tea Taste and Quality Affected by Climate Change 3Tea Taste and Quality Affected by Climate Change 4
... 7 /PRNewswire-FirstCall/ - Dragon Pharmaceutical Inc. ("Dragon" or the ... receipt of preliminary proxies, the Company believes that it has ... ("Merger") by and among Dragon, Chief Respect Limited, Datong Investment ... Yanlin Han . The Merger must be approved by holders ...
... , , ... a 25 percent replacement for petroleum oil more than doubles rubber,s stretchability and reduces its environmental ... Ford,s ... automotive parts such as deflector shields and baffles, radiator deflector shields, cupholder inserts and floor mats ...
... DATATRAK International, Inc. (OTCQX: DATA), a technology and services ... industry, today announced that it privately placed 357,857 common shares ... with certain members of its Board of Directors and management ... are restricted securities and are subject to the restrictions on ...
Cached Biology Technology:Dragon Pharma announces receipt of preliminary proxies to approve merger 2Dragon Pharma announces receipt of preliminary proxies to approve merger 3Ford Pioneers Patent-Pending Use of Eco-Friendly Soy Oil in Rubber Automotive Parts 2Ford Pioneers Patent-Pending Use of Eco-Friendly Soy Oil in Rubber Automotive Parts 3Ford Pioneers Patent-Pending Use of Eco-Friendly Soy Oil in Rubber Automotive Parts 4DATATRAK Completes Sale of 357,857 Common Shares to Directors and Management 2DATATRAK Completes Sale of 357,857 Common Shares to Directors and Management 3