Navigation Links
The making and breaking of microtubules

Microtubules are active protein polymers critical to the structure and function of cells and the process of cell division. In a living cell their growing ends constantly elongate and retreat in a thrashing frenzy of polymerization and depolymerization, like the writhing snakes of Medusa's hair. Known prosaically as "dynamic instability," this ongoing rapid growth and shrinkage is key to the diverse workings of microtubules in the cell.

For the first time, researchers have revealed at molecular level the forms taken by transitional structures of tubulin (the protein from which microtubules are formed) during the assembly and disassembly of microtubules. Details of these peculiar structures show how the binding to tubulin of the nucleotide guanosine triphosphate, GTP, controls activity at the growing end of the microtubule. Eva Nogales and Hong-Wei Wang of the Life Sciences Division of the Department of Energy's Lawrence Berkeley National Laboratory report their findings in the 16 June 2005, issue of the journal Nature.

"Tubulin is a major target for anticancer drugs, which can prevent the transition from growing to shrinking states or vice versa," says Nogales, who is also a member of Berkeley Lab's Physical Biosciences Division, an associate professor of biochemistry and molecular biology at the University of California at Berkeley, and a Howard Hughes Medical Institute Investigator. "We had previously produced high-resolution structures of stabilized tubulin structures, but nobody knew the structure of the transitional states. Our goal was to understand the process of microtubule assembly and disassembly."

"Our current work actually revealed the structures of different tubulin assemblies at the very ends of growing microtubules and depolymerizing microtubules," says Wang. "This allows a new understanding of the mechanism of microtubule dynamic instability, opening opportunities for new experiments testing the physiological roles of these micr
'"/>

Source:DOE/Lawrence Berkeley National Laboratory


Page: 1 2 3 4 5

Related biology news :

1. Drug That Tags Decision-making Areas Of The Brain May Aid
2. Whats really making you sick? Plant pathologists offer the science behind Sick Building Syndrome
3. Understanding biases in epidemic models important when making public health predictions
4. The making of a fat cell
5. Micro RNAs play role in egg making
6. Creationism is not science ?making the case for Darwin at UCL
7. Honeybee decision-making ability rivals any department committee
8. Ten years later, Dolly is still making headlines
9. Microbes compete with animals for food by making it stink
10. New fMRI technology making brain tumor surgery safer
11. Are scientists making progress in being able to regenerate bone tissue?
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: The making and breaking microtubules

(Date:7/11/2014)... evidence has demonstrated that transplantation of mesenchymal stem cells ... or mouse models of Alzheimer,s disease (AD) and improve ... ischemia. Few studies are reported on the therapeutic effect ... AD and on the effect on oxidative injury and ... Yan and her team, School of Life Sciences, Tsinghua ...
(Date:7/11/2014)... that cannabinoid receptor type 1 can inhibit ... and reduce neurotransmitter release. However, some scholars ... increase extracellular Ca2+ influx and increase neurotransmitter ... Tongji Hospital Affiliated to Tongji Medical College, ... used whole cell voltage-clamp and calcium imaging ...
(Date:7/11/2014)... brains of all vertebrates, information is transmitted through ... chemical signal to be passed from one brain ... most abundant type of synapse, can be either ... learning, memory, perception and cognition, and the balance ... function. For instance, every time we learn ...
Breaking Biology News(10 mins):Blame it on the astrocytes 2
... May 3, 2010-Conventional agriculture production relies heavily on fossil ... a low cost. However, the uncertain future of fossil ... energy efficiencies in other cropping systems. Most of ... of corn and soybean with heavy inputs of fertilizer, ...
... May 3, 2010 Genes interact in complex networks that ... through relationships. Researchers are now discovering how biological networks ... published today in Genome Research ( www.genome.org ), ... shedding light on how interactions go awry in disease. ...
... May 2 Scientists at the University of Pittsburgh School ... a catch of new mediators that not only can explain ... novel treatments for a host of diseases linked to inflammatory ... of Nature Chemical Biology . There is strong ...
Cached Biology News:Reducing fossil energy use on the farm 2Reducing fossil energy use on the farm 3MicroRNA network study implicates rewired interactions in cancer 2Pitt pharmacologists go on a molecular fishing trip and hook prize catch 2
(Date:7/10/2014)... Los Angeles, CA (PRWEB) July 10, 2014 ... Analytical and Bioanalytical techniques during 18-20 August, 2014 at ... to critically review the recent developments in Analytical & ... across the globe. , Speaking on this occasion, Dr. ... that Analytica Acta conference is a remarkable one ...
(Date:7/10/2014)... , July 10, 2014  Kainos Capital, a firm ... today announced that it has acquired the Slim-Fast brand ... the business. Terms of the transaction were not disclosed. ... meal replacement business that markets ready-to-drink shakes, powders, bars ... America and in the United ...
(Date:7/10/2014)... help in the fight against terrorism with the creation ... explosives with the use of light and special glass ... Actuators B: Chemical , the researchers describe a novel ... as low as 6.3 ppm (parts per million). It ... , "Traditionally explosives detection has involved looking for metals ...
(Date:7/10/2014)... batteries that power our laptops and electric vehicles could ... charge with the help of a sponge-like silicon material. ... the graphite traditionally used in one of the battery,s ... energy storage capacity of graphite. A paper describing the ... today in Nature Communications . , "Silicon has ...
Breaking Biology Technology:A Critical Review of Analytical Techniques for Improved Living Standards 2A Critical Review of Analytical Techniques for Improved Living Standards 3A Critical Review of Analytical Techniques for Improved Living Standards 4Kainos Capital Acquires Slim-Fast From Unilever 2Detecting trace amounts of explosives with light 2Silicon sponge improves lithium-ion battery performance 2Silicon sponge improves lithium-ion battery performance 3
... the diuretic hydrochlorothiazide (HCTZ) in ... in significant additional blood pressure reductions compared to either drug alone ... or more, medicines - single-tablet combinations simplify treatment by reducing ... number of pills patients take, EAST ...
... Named ,Illinois Rising Stars, CHICAGO, Jan. 18 ... property law firms in the United States, is,pleased to ... "Illinois,Super Lawyers" for 2008 in a survey conducted by ... designated "Rising Stars" in,Illinois., Meredith Martin Addy, chair ...
... Jan. 18 Abbott (NYSE: ABT ),announced today ... for its fully automated HTLV-I/HTLV-II blood screening test,for use ... for use by,laboratories to screen individual donations of blood ... Type I and/or human T --,lymphotropic virus Type II ...
Cached Biology Technology:Video and Photo: Tekturna HCT(R), a Single-tablet Combination of Tekturna(R)* and a Diuretic, Receives US Approval for Treatment of High Blood Pressure 2Video and Photo: Tekturna HCT(R), a Single-tablet Combination of Tekturna(R)* and a Diuretic, Receives US Approval for Treatment of High Blood Pressure 3Video and Photo: Tekturna HCT(R), a Single-tablet Combination of Tekturna(R)* and a Diuretic, Receives US Approval for Treatment of High Blood Pressure 4Video and Photo: Tekturna HCT(R), a Single-tablet Combination of Tekturna(R)* and a Diuretic, Receives US Approval for Treatment of High Blood Pressure 5Twenty-One Brinks Hofer Gilson & Lione Attorneys Named 2008 'Illinois Super Lawyers' 2Abbott Announces Approval of First Fully Automated Blood Screening Test for HTLV-I/HTLV-II 2Abbott Announces Approval of First Fully Automated Blood Screening Test for HTLV-I/HTLV-II 3