Navigation Links
The making and breaking of microtubules

Microtubules are active protein polymers critical to the structure and function of cells and the process of cell division. In a living cell their growing ends constantly elongate and retreat in a thrashing frenzy of polymerization and depolymerization, like the writhing snakes of Medusa's hair. Known prosaically as "dynamic instability," this ongoing rapid growth and shrinkage is key to the diverse workings of microtubules in the cell.

For the first time, researchers have revealed at molecular level the forms taken by transitional structures of tubulin (the protein from which microtubules are formed) during the assembly and disassembly of microtubules. Details of these peculiar structures show how the binding to tubulin of the nucleotide guanosine triphosphate, GTP, controls activity at the growing end of the microtubule. Eva Nogales and Hong-Wei Wang of the Life Sciences Division of the Department of Energy's Lawrence Berkeley National Laboratory report their findings in the 16 June 2005, issue of the journal Nature.

"Tubulin is a major target for anticancer drugs, which can prevent the transition from growing to shrinking states or vice versa," says Nogales, who is also a member of Berkeley Lab's Physical Biosciences Division, an associate professor of biochemistry and molecular biology at the University of California at Berkeley, and a Howard Hughes Medical Institute Investigator. "We had previously produced high-resolution structures of stabilized tubulin structures, but nobody knew the structure of the transitional states. Our goal was to understand the process of microtubule assembly and disassembly."

"Our current work actually revealed the structures of different tubulin assemblies at the very ends of growing microtubules and depolymerizing microtubules," says Wang. "This allows a new understanding of the mechanism of microtubule dynamic instability, opening opportunities for new experiments testing the physiological roles of these micr
'"/>

Source:DOE/Lawrence Berkeley National Laboratory


Page: 1 2 3 4 5

Related biology news :

1. Drug That Tags Decision-making Areas Of The Brain May Aid
2. Whats really making you sick? Plant pathologists offer the science behind Sick Building Syndrome
3. Understanding biases in epidemic models important when making public health predictions
4. The making of a fat cell
5. Micro RNAs play role in egg making
6. Creationism is not science ?making the case for Darwin at UCL
7. Honeybee decision-making ability rivals any department committee
8. Ten years later, Dolly is still making headlines
9. Microbes compete with animals for food by making it stink
10. New fMRI technology making brain tumor surgery safer
11. Are scientists making progress in being able to regenerate bone tissue?
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: The making and breaking microtubules

(Date:7/24/2014)... 2014 -- Keryx Biopharmaceuticals, Inc. (Nasdaq:KERX) (the "Company") announced ... control Phase 3 study of Zerenex (ferric citrate), the ... treatment of hyperphosphatemia in patients with end-stage renal disease ... iRon delivery with FErric CiTrate in EsrD) was published ... Society of Nephrology ( JASN ). ...
(Date:7/24/2014)... (July 24, 2014) Scientists at The New ... one step closer to creating a viable cell ... own cells. , For the first time, ... lines from skin samples of patients with primary ... accelerated protocol to induce these stem cells into ...
(Date:7/24/2014)... numbers have decreased by 45% on average over a ... reports a study on the impact of humans on ... enormous benefits invertebrates such as insects, spiders, crustaceans, slugs ... and pest control for crops, decomposition for nutrient cycling, ... in Science and led by UCL, Stanford ...
Breaking Biology News(10 mins):Zerenex™ (ferric citrate) long-term Phase 3 study results published in JASN 2Zerenex™ (ferric citrate) long-term Phase 3 study results published in JASN 3Zerenex™ (ferric citrate) long-term Phase 3 study results published in JASN 4NYSCF scientists 1 step closer to cell therapy for multiple sclerosis patients 2Invertebrate numbers nearly halve as human population doubles 2Invertebrate numbers nearly halve as human population doubles 3
... rainfall are affecting the survival of elephants working in ... of death in calves aged up to five, new ... With climate change models predicting higher temperatures and ... already endangered Asian elephants. The researchers matched monthly ...
... TN Since the mid-nineteenth century, maps have helped ... yellow fever. Yet today,s global mapping of infectious diseases ... the control of potential outbreaks, according to a new ... known to humans., Of the 355 infectious diseases assessed ...
... mental health leads to unhealthy behaviors in low-income adults ... new study by Dr. Jennifer Walsh and colleagues from ... Miriam Hospital in the US. In this study, stress ... binge drinking, illegal drug use, unprotected sex and unhealthy ...
Cached Biology News:Low rainfall and extreme temperatures double risk of baby elephant deaths 2Avoiding a cartography catastrophe 2Poor mental health leads to unhealthy behaviors among low-income adults 2
(Date:7/25/2014)... , July 25, 2014 Amgen (NASDAQ: ... Directors today declared a $0.61 per share dividend for ... paid on Sept. 5, 2014, to all stockholders of ... 14, 2014.  About Amgen Amgen is ... suffering from serious illnesses by discovering, developing, manufacturing and ...
(Date:7/25/2014)... , July 25, 2014 Research ... "Global Metabolomics Market 2014-2018" report to ... Metabolomics or Metabonomics is the ... has become a new experimental technique that is ... environmental sciences. Metabolites are small molecules that are ...
(Date:7/25/2014)... Pittsburgh, PA (PRWEB) July 25, 2014 ... annual Call for Topics for Conferee Networking. These two-hour ... similar interests to meet and resolve problems, discuss new ... , The deadline to submit a topic for consideration ... at pittcon.org . The Conferee Networking committee will ...
(Date:7/25/2014)... , July 25, 2014 /PRNewswire-iReach/ -- Xybion Corporation, ... for global corporations operating in highly regulated industries, ... first annual Global User Group Conference, Xybion International ... Philadelphia, Pennsylvania at the Sheraton ... http://photos.prnewswire.com/prnh/20140724/130263 This year,s conference ...
Breaking Biology Technology:Amgen Announces 2014 Third Quarter Dividend 2Amgen Announces 2014 Third Quarter Dividend 3Global Metabolomics Market 2014-2018: Key Vendors are Agilent, Bio-Rad, Bruker, Human Metabolome and Metabolon 2Pittcon 2015 Announces Call for Topics for Conferee Networking Sessions 2Xybion Announces It Will Host International User Conference in Philadelphia 2Xybion Announces It Will Host International User Conference in Philadelphia 3
... /PRNewswire-Asia-FirstCall/ -- ... ... var shortURL = ""; ... we need to grab the first one. for (var r in data.results) { first_result = data.results[r]; break; ...
... Sept. 7 The Plasma Protein Therapeutics Association (PPTA) ... (CMS) finalize its Proposed Rule regarding reimbursement to better ... outpatient setting. Specifically, for CY 2011, ... payable non-pass-through drugs and biologicals, which include most plasma ...
... Md., Sept. 3 The Maryland Stem Cell Research ... Cell Research Symposium in partnership with the National Institutes ... and Technology (NIST) on Wednesday, Sept. 22, 2010. The ... Life Science Research," will be held at the NIST ...
Cached Biology Technology:Yongye International to Present at Rodman & Renshaw Annual Global Investment Conference 2Yongye International to Present at Rodman & Renshaw Annual Global Investment Conference 3Yongye International to Present at Rodman & Renshaw Annual Global Investment Conference 4Yongye International to Present at Rodman & Renshaw Annual Global Investment Conference 5Yongye International to Present at Rodman & Renshaw Annual Global Investment Conference 6Yongye International to Present at Rodman & Renshaw Annual Global Investment Conference 7PPTA Urges CMS for Appropriate Hospital Outpatient Reimbursement for Plasma Protein Therapies 2PPTA Urges CMS for Appropriate Hospital Outpatient Reimbursement for Plasma Protein Therapies 3Maryland Stem Cell Research Commission to Host Third Annual Maryland Stem Cell Research Symposium 2Maryland Stem Cell Research Commission to Host Third Annual Maryland Stem Cell Research Symposium 3
RAB32, member RAS oncogene family, mRNA (cDNA clone MGC:13500 IMAGE:4280407), complete cds...
EDTA, 0.5 M solution, 100 ml. Ethylene diaminetetraacetic acid.Sterile, nuclease-free. Category: Nucleotides & Enzymes & Biochemicals, Ultrapure Biochemicals ....
Human VEGF-D Biotinylated MAb (Clone 78923)...
One-step, microplate or cuvet, colorimetric, linear detection range 0.2 mg/dL to 20 mg/dL. Procedure: 20 min....
Biology Products: