Navigation Links
The giant protein titin helps build muscles

etailed image of the connections between the proteins they discovered that telethonin links the tails in a unique way that may give some clues to sarcomere assembly.

The Gautel lab used advanced microscope techniques to watch the molecules link to each other in live cells. "We knew that telethonin acted as a sort of 'cap' or 'bolt' at the end of the titin molecule," Gautel says. "What we couldn't see is how it connected two separate copies of titin together. That's what this study has shown."

Wilmanns adds: "We discovered that telethonin has a kind of internal symmetry that lets it grasp two titin molecules running off in opposite directions. That's new. We've discovered other single proteins that can link to DNA molecules in 'palindromes', but this is the first time we have seen proteins themselves linked like this."

Other molecules enter the Z-disk from sarcomeres on both sides; it is likely, the scientists think, that some of the connections follow the example of titin and telethonin. The groups will now look for other examples. The terminal assembly complex investigated in this work, though, only covers a tiny part of the giant muscle protein titin, which possesses tens of thousands of amino acids in some isoforms. "There are probably hundreds or even thousands of more interactions down the road. We have found one of the first and eagerly anticipate discovering many others, probably coming with lots of surprises," Wilmanns concludes. "We have just started to get insight into one of the most complex systems in the human body."

"This work is a nice example of how modern biology combines approaches from cell biophysics and structural biology, and it gives us a way to discover why some mutations in titin are linked to diseases," says Gautel.


'"/>

Source:European Molecular Biology Laboratory


Page: 1 2

Related biology news :

1. Small species back-up giant marsupial climate change extinction claim
2. Researchers find new giant amphibian fossils in Africa
3. Extinct giant deers descendant found in UK
4. One small step means giant leap for spinal cord research
5. Brighter future for giant panda?
6. A giant among minnows: Giant danio can keep growing
7. Prehistoric mystery organism verified as giant fungus
8. New, automated tool successfully classifies and relates proteins in unprecedented way
9. New binding target for oncogenic viral protein
10. Controversial drug shown to act on brain protein to cut alcohol use
11. Timing is everything: First step in protein building revealed
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: The giant protein titin helps build muscles

(Date:10/29/2014)... in New York City on September 19, 2014, leading ... Society Professor of Genome Sciences and Medicine at the ... of Philosophy of Tel Aviv University, was awarded the ... In addition to her honorary degree from TAU, Prof. ... School of Medicine, and for the past 18 years ...
(Date:10/29/2014)... potential of the Barcode of Life Data Systems ... Biodiversity Data Journal (BDJ) used specimen ... these into a human-readable text developed in manuscript within ... used to study the species distributions of ten Nearctic ... BOLD is originally designed to support the generation and ...
(Date:10/29/2014)... Genomics of the Kidney consortium ( CAGEKID ) ... exposure to aristolochic acid, an ingredient in some ... Communications , have important implications for public health. ... every year, and in Central Europe incidence rates ... International Cancer Genome Consortium (ICGC), has been studying ...
Breaking Biology News(10 mins):Geneticist and humanitarian: Prof. Mary-Claire King receives Lasker Award 2Go straight and publish: From Barcode of Life Data Systems to scholarly publishing systems 2Kidney cancer in Central Europe 2
... amphibians developed the ability to feed on land before ... University report this week in the Proceedings of the ... on analysis of the skulls of the first amphibians, ... ancestors. The shapes of the junctions between adjacent skull ...
... Atlantic Ocean doesn't receive the mother lode of fixed nitrogen, ... for fathom, the Pacific and Indian oceans experience twice the ... the Jan. 11 issue of Nature. , The title of ... for N2 Fixation in all the Wrong Places." ...
... Why have large outbreaks of Ebola virus killed tens ... decade? Observations published in the May issue of The ... be amplified by Ebola transmission between ape social groups. ... control the devastating impact of Ebola on wild apes. ...
Cached Biology News:Ancient amphibians evolved a bite before migrating to dry land 2New findings blow a decade of assumptions out of the water 2New findings blow a decade of assumptions out of the water 3Ebola outbreaks killing thousands of gorillas and chimpanzees 2
(Date:10/27/2014)... , October 27, 2014 ... right to produce, exhibit and sell its artificial ... to impeach their patent.      (Photo: ... four years of fighting, the definitive judgement has ... and produces innovative and accessible hi-tech prostheses with ...
(Date:10/27/2014)... The “Molecular Diagnostic Market by Application ... DNA Sequencing), End User (Hospital, Laboratories), & by ... to 2018” provides a detailed overview of the ... and strategies impacting the global molecular diagnostics market ... revenue and share analysis. , The global molecular ...
(Date:10/27/2014)... 27, 2014 The report “Smart ... Traffic Management, Communication, Monitoring), and by Display (Variable ... 2019” segments the global market into various sub-segments ... also identifies the drivers and restraints for this ... , Browse 75 market tables and 37 figures ...
(Date:10/27/2014)... October 27, 2014 Investor-Edge has ... (NASDAQ: NBIX ), Insmed Inc. (NASDAQ: ... BCRX ), Dyax Corporation (NASDAQ: DYAX ), ... five companies can be accessed at: http://investor-edge.com/register ... Composite ended at 4,483.72, up 0.69%, the Dow Jones ...
Breaking Biology Technology:Italian Lower Limb Prosthesis Company Wins Lawsuit Against German Giant Ottobock 2Global Molecular Diagnostics Market Will Reach $7.9 Billion by 2018 - New Research Report by MarketsandMarkets 2Global Molecular Diagnostics Market Will Reach $7.9 Billion by 2018 - New Research Report by MarketsandMarkets 3Global Molecular Diagnostics Market Will Reach $7.9 Billion by 2018 - New Research Report by MarketsandMarkets 4Global Molecular Diagnostics Market Will Reach $7.9 Billion by 2018 - New Research Report by MarketsandMarkets 5Smart Highway Market by Technology, and Display Expected to Reach $27.992.0 Million by 2019- New Report by MarketsandMarkets 2Smart Highway Market by Technology, and Display Expected to Reach $27.992.0 Million by 2019- New Report by MarketsandMarkets 3Smart Highway Market by Technology, and Display Expected to Reach $27.992.0 Million by 2019- New Report by MarketsandMarkets 4Pre-market Equity Watch on Biotech Industry - Neurocrine Biosciences, Insmed, BioCryst Pharma, Dyax, and Oncothyreon 2Pre-market Equity Watch on Biotech Industry - Neurocrine Biosciences, Insmed, BioCryst Pharma, Dyax, and Oncothyreon 3Pre-market Equity Watch on Biotech Industry - Neurocrine Biosciences, Insmed, BioCryst Pharma, Dyax, and Oncothyreon 4Pre-market Equity Watch on Biotech Industry - Neurocrine Biosciences, Insmed, BioCryst Pharma, Dyax, and Oncothyreon 5
... At the 44th Annual Meeting of,the American Society ... the potential utility of Zevalin(R) (Ibritumomab,Tiuxetan) radioimmunotherapy as ... chemotherapy in the treatment of non-Hodgkin,s,lymphoma (NHL). Cell ... markets,Zevalin in the United States., "These two ...
... CITY, China, May 30 /Xinhua-PRNewswire-FirstCall/ -- China,Pharma Holdings, ... which develops, manufactures, and markets generic and branded,bio-pharmaceutical ... 30, 2008,it closed its recently announced financing, issuing ... price of $2.00 per share and three-year warrants,to ...
... PRINCETON, N.J., May 30 Pharmacopeia (Nasdaq:,PCOP), an ... small,molecule therapeutics, announced today that it is implementing ... its resources on the company,s clinical,and later-stage discovery ... approximately 15 percent through attrition and,termination of positions ...
Cached Biology Technology:Investigational Studies Highlight Potential Utility of Zevalin(R) (Ibritumomab Tiuxetan) Radioimmunotherapy in Stem Cell Transplantation for Non-Hodgkin's Lymphoma 2Investigational Studies Highlight Potential Utility of Zevalin(R) (Ibritumomab Tiuxetan) Radioimmunotherapy in Stem Cell Transplantation for Non-Hodgkin's Lymphoma 3Investigational Studies Highlight Potential Utility of Zevalin(R) (Ibritumomab Tiuxetan) Radioimmunotherapy in Stem Cell Transplantation for Non-Hodgkin's Lymphoma 4China Pharma Holdings, Inc. Closes $10 Million Financing 2China Pharma Holdings, Inc. Closes $10 Million Financing 3Pharmacopeia Advances Strategic Plan to Focus Resources on Development and Later-Stage Discovery Programs 2Pharmacopeia Advances Strategic Plan to Focus Resources on Development and Later-Stage Discovery Programs 3Pharmacopeia Advances Strategic Plan to Focus Resources on Development and Later-Stage Discovery Programs 4
... The ProteoExtract™ Protein Precipitation Kit ... up of proteins from aqueous samples. ... by the presence of non-protein impurities ... in the protein sample that interfere ...
... activated carrier proteins to simplify the ... Activated Carrier Proteins are commonly used ... a heterobifunctional cross-linker (Sulfo-SMCC). This activation ... protein. Thus allowing the maleimide-activated ...
... This kit allows for rapid, convenient, ... The simple bind/wash/elute process utilizes a spin ... uses beads for concentration of proteins which ... beads are strong ion exchangers, offering high ...
... optically clear polystyrene with frosted labeling ... for cell counting. 100% integrity tested. ... new product number, created to easily ... no availability yet, please order under ...
Biology Products: