Navigation Links
The giant protein titin helps build muscles

Imagine grabbing two snakes by the tail so that they can't wriggle off in opposite directions. Scientists at the Hamburg Outstation of the European Molecular Biology Laboratory (EMBL) and collaborators from King's College in London have now discovered that something similar happens to a protein that is crucial in the formation of muscle tissue. Their work appears in the current issue of the journal Nature.

Under the microscope, muscle looks like millions of tiny pistons, stacked end-to-end into long rows. These structures, called sarcomeres, permit the contraction and relaxation of muscle that allow our bodies to move. Sarcomeres are connected at the ends by Z-disks, thick bands of densely-packed molecules. "Sarcomeres are very complex structures, and for many years we've been investigating the steps by which they are formed," says Matthias Wilmanns, Head of the EMBL Hamburg Outstation. "That probably starts when proteins link up to each other in very big assemblies. The meeting point is the Z-disk, but unraveling the connections has been difficult."

Wilmanns' lab and the team of Mathias Gautel, an EMBL alumnus and now at King's College, have thought that a molecule called titin, the largest protein made by human cells, is involved. Titin is anchored in the Z-disk and is so long that it spans half the length of a sarcomere. Its size and position ?putting it into contact with all the majorcomponents of sarcomeres ?suggests that it might help in their assembly.

The latest study, which arises from more than a decade of collaborative research by the Wilmanns and Gautel teams, gives a solution to how this might happen. Peijian Zou and Nikos Pinotsis from the Wilmanns lab obtained crystals of parts of the titin molecule bound to another protein, called telethonin. They analyzed the crystals on high-energy X-ray beamlines at EMBL's Hamburg station, on the site of the German Electron Synchrotron Radiation Facility (DESY). From the extremely d
'"/>

Source:European Molecular Biology Laboratory


Page: 1 2

Related biology news :

1. Small species back-up giant marsupial climate change extinction claim
2. Researchers find new giant amphibian fossils in Africa
3. Extinct giant deers descendant found in UK
4. One small step means giant leap for spinal cord research
5. Brighter future for giant panda?
6. A giant among minnows: Giant danio can keep growing
7. Prehistoric mystery organism verified as giant fungus
8. New, automated tool successfully classifies and relates proteins in unprecedented way
9. New binding target for oncogenic viral protein
10. Controversial drug shown to act on brain protein to cut alcohol use
11. Timing is everything: First step in protein building revealed
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: The giant protein titin helps build muscles

(Date:4/1/2015)...  NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or ... growing mobile commerce market, announces the second shipment of ... to early access pre-order customers. Feedback ... outlets including Walmart, Target, AT&T, Dunkin, Donuts, Stop & ... at all outlets and very easy to use. Several ...
(Date:3/31/2015)... -- Elephant Talk Communications Corp. (NYSE MKT: ETAK) ("Elephant Talk" ... Network Architecture (ET Software DNA® 2.0) platforms and cyber ... million for the year ended December 31, 2014 as ... ended December 31, 2013. At the ... multi-year transition away from its legacy landline business to ...
(Date:3/30/2015)... and Markets ( http://www.researchandmarkets.com/research/lc9bnl/global_gesture ) has announced ... in Automotive Sector 2014-2018" report to their offering. ... market in Automotive Sector to grow at a CAGR ... recognition is the ability of a device to identify ... recognition technology can be 2D-based or 3D-based. It uses ...
Breaking Biology News(10 mins):NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 2NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 3NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 4Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 2Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 3Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 4Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 5Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 6Global Gesture Recognition Market in Automotive Sector Report 2015 - Growing Number of Partnerships 2
... and muscles around the mouth plays an important role not only ... in the way they are heard according to a study by ... your own face is moving makes a difference in how you ... scientist at Haskins. When, Ito and his colleagues used a ...
... University political science professor is working with Southern ... trade agreements that could threaten the world,s food ... Thompson has been consulting on international agriculture trade ... living in Southern African countries studying agricultural expertise ...
... that face mankind and the environment, there is ... policy, business and education that new, more integrative ... interdisciplinary and multidisciplinary approaches to solving problems at ... at the institutional level. , Integrated Science − ...
Cached Biology News:Feeling your words: Hearing with your face 2New book plants seed for biodiverse food production 2New book plants seed for biodiverse food production 3
(Date:5/1/2015)... , May 1, 2015 ... equities: Genetic Technologies Ltd (NASDAQ: GENE ), ... Fisher Scientific Inc. (NYSE: TMO ), Sequenom ... (NYSE: PKI ). Free research report on ... . On Thursday, April 30, 2015, the NASDAQ ...
(Date:5/1/2015)... TRIANGLE PARK, N.C. , May 1, 2015  United ... Roger Jeffs , Ph.D., President and Co-Chief Executive Officer of ... company,s business at the Deutsche Bank 40 th Annual ... The presentation will take place on Wednesday, May ... accessed via a live webcast on the United Therapeutics website ...
(Date:4/30/2015)... , April 30, 2015   Tamir Biotechnology ... today an update on its Ebola antiviral therapy program. ... leading candidates, TMR004, is currently being evaluated and considered ... the battle against Ebola. During the first quarter of ... Leadership Meeting To Accelerate The Evaluation of Potential Treatments ...
(Date:4/30/2015)... 30, 2015 Nitto Avecia, a ... its increased capacity and production capability to serve ... variety and service fulfillment continues to drive Nitto ... process throughput capacities. , In Fall ... downstream process equipment at its Milford, MA facility, ...
Breaking Biology Technology:Life Sciences Tools and Services Stocks on our Radar -- Genetic Technologies, Agilent Technologies, Thermo Fisher Scientific, Sequenom, and PerkinElmer 2Life Sciences Tools and Services Stocks on our Radar -- Genetic Technologies, Agilent Technologies, Thermo Fisher Scientific, Sequenom, and PerkinElmer 3Life Sciences Tools and Services Stocks on our Radar -- Genetic Technologies, Agilent Technologies, Thermo Fisher Scientific, Sequenom, and PerkinElmer 4Life Sciences Tools and Services Stocks on our Radar -- Genetic Technologies, Agilent Technologies, Thermo Fisher Scientific, Sequenom, and PerkinElmer 5Tamir Biotechnology Provides Update on TMR004 Development Against Mutating Ebola 2Tamir Biotechnology Provides Update on TMR004 Development Against Mutating Ebola 3Tamir Biotechnology Provides Update on TMR004 Development Against Mutating Ebola 4Biotechnology Manufacturer Nitto Avecia Expands Capacity to Meet Client Demand 2
... ,Over 40% of Stratagenes GeneConnection cDNA gene clusters ... be full-length clones , Jason Goncalves Jean-Michel ... cDNA clone collection YY ,goes beyond ... human tissues and has identified thousands of cDNAs that ...
... difficult transfections when using the,complete control kit ... , We describe the vector pFB-ERV, an MMLV-based ... proteins RXR and VgEcR.,In stable cell lines infected ... induction ratios of greater than 200-fold are attainable ...
... XL1-Red cells allow isolation of gene products,with altered ... Markus M.,Enzelberger ,Institute for Technical Biochemistry, University ... Industrial Genetics, University of Stuttgart, Stuttgart,Germany , Hartmut ... Hannover, Hannover, Germany , Mutants of an esterase ...
Cached Biology Technology:The GeneZoo or the GeneJungle? 2The GeneZoo or the GeneJungle? 3The GeneZoo or the GeneJungle? 4The GeneZoo or the GeneJungle? 5The GeneZoo or the GeneJungle? 6The GeneZoo or the GeneJungle? 7The GeneZoo or the GeneJungle? 8The GeneZoo or the GeneJungle? 9The GeneZoo or the GeneJungle? 10pFB-ERV: Retroviral Delivery of the Ecdysone Receptor Proteins 2pFB-ERV: Retroviral Delivery of the Ecdysone Receptor Proteins 3pFB-ERV: Retroviral Delivery of the Ecdysone Receptor Proteins 4pFB-ERV: Retroviral Delivery of the Ecdysone Receptor Proteins 5pFB-ERV: Retroviral Delivery of the Ecdysone Receptor Proteins 6Using XL1-Red Mutator Strain to Generate Esterase Variants 2Using XL1-Red Mutator Strain to Generate Esterase Variants 3Using XL1-Red Mutator Strain to Generate Esterase Variants 4Using XL1-Red Mutator Strain to Generate Esterase Variants 5
... PureLink PCR Purification Kits provide rapid ... enzymes, short-failed PCR products, and salts from ... bind/wash/elute procedure:, provides two Binding Buffer ... bp* , can be performed in either ...
...
Immunogen: Recombinant full length protein. Storage: -20 C, Avoid Freeze/Thaw Cycles...
...
Biology Products: